RHOA Protein (His tag)

N° du produit ABIN7317377

Détail du produit

Antigène: RHOA (Ras Homolog Gene Family, Member A (RHOA))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette RHOA protéine est marqué à la His tag.

Fonction: Recombinant Human RhoA Protein (His Tag)

Séquence: Met 1-Leu 193

Attributs du produit: A DNA sequence encoding the human RHOA (P61586-1) (Met 1-Leu 193) was fused with a polyhistidine tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: RHOA (Ras Homolog Gene Family, Member A (RHOA))

Autre désignation: RhoA (RHOA Produits)

Synonymes: ARH12 Protein, ARHA Protein, RHO12 Protein, RHOH12 Protein, Arha Protein, Arha1 Protein, Arha2 Protein, arha Protein, arha2 Protein, xrhoa Protein, arh12 Protein, rho12 Protein, rhoh12 Protein, rhoa Protein, RHO1 Protein, Rhoa Protein, wu:fa66g04 Protein, wu:fb26g07 Protein, zgc:66058 Protein, zgc:85805 Protein, ARHC Protein, rhoae Protein, zgc:64015 Protein, ras homolog family member A Protein, ras homolog family member A S homeolog Protein, ras homolog family member A L homeolog Protein, ras homolog gene family, member Aa Protein, ras homolog family member Ca Protein, RHOA Protein, Rhoa Protein, rhoa.S Protein, rhoa Protein, rhoa.L Protein, rhoaa Protein, rhoca Protein

Sujet:

Background: Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein which belongs to the small GTPase superfamily and Rho family. The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. RHOA / ARH12 is part of a larger family of related proteins known as the Ras superfamily; proteins involved in the regulation and timing of cell division. RHOA / ARH12 is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. It acts upon two known effector proteins: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 ( diaphanous homolog 1 (Drosophila) ). RHOA / ARH12 regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. RHOA / ARH12 serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. RHOA / ARH12 may be an activator of PLCE1. It is activated by ARHGEF2, which promotes the exchange of GDP for GTP.

Synonym: ARH12;ARHA;RHO12;RHOH12

Poids moléculaire: 24 kDa

Pathways: Dynamique des Microtubules, Signalisation WNT, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, SARS-CoV-2 Protein Interactome