SFRP4 Protein (His tag)

N° du produit ABIN7320416

Détail du produit

Antigène: SFRP4 (Secreted Frizzled-Related Protein 4 (SFRP4))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette SFRP4 protéine est marqué à la His tag.

Fonction: Recombinant Mouse sFRP4 Protein (His Tag)

Séquence: Met 1-Ser 351

Attributs du produit: A DNA sequence encoding the mouse sFRP4 (NP_057896.1) (Met 1-Ser 351) was expressed with a C-terminal polyhistidine tag.

Pureté: > 97 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SFRP4 (Secreted Frizzled-Related Protein 4 (SFRP4))

Autre désignation: sFRP4 (SFRP4 Produits)

Synonymes: SFRP4 Protein, FRP-4 Protein, FRPHE Protein, sFRP-4 Protein, secreted frizzled related protein 4 Protein, secreted frizzled-related protein 4 Protein, SFRP4 Protein, Sfrp4 Protein

Sujet:

Background: SFRP family consists of five secreted glycoproteins in humans acting as extracellular signaling ligands. Each is approximately 300 amino acids in length and contains a cysteine-rich domain (CRD) that shares 30-50% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs act as soluble modulators of Wnt signaling, counteracting Wnt-induced effects at high concentrations and promoting them at lower concentrations. SFRPs are able to bind Wnt proteins and Fz receptors in the extracellular compartment. The interaction between SFRPs and Wnt proteins prevents the latter from binding the Fz receptors. The Wnt pathway plays a key role in embryonic development, cell differentiation and cell proliferation. SFRP4 is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins called FZ domain and a NTR domain . Mouse SFRP4 is highly expressed in the ovary, and is localized to granulosa cells of periovulatory follicles and corpora lutea. It plays a critical role in placental development and implantation, and is also an important factor in the development of the decidual fibrinoid zone, and in trophoblast apoptosis.

Synonym: Sfrp4

Poids moléculaire: 39.4 kDa

NCBI Accession: NP_057896

Pathways: Signalisation WNT