AXL Protein (AA 26-449) (Fc Tag)
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- Antigène Voir toutes AXL Protéines
- AXL (AXL Receptor tyrosine Kinase (AXL))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 26-449
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette AXL protéine est marqué à la Fc Tag.
- Fonction
- Human AXL Protein
- Séquence
- Ala26-Pro449
- Attributs du produit
- Recombinant Human AXL Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ala26-Pro449.
- Pureté
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human GAS6, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human AXL, hFc Tag with the EC50 of 7.5ng/ml determined by ELISA. See testing image for detail.
- Top Product
- Discover our top product AXL Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- AXL (AXL Receptor tyrosine Kinase (AXL))
- Autre désignation
- Axl (AXL Produits)
- Synonymes
- JTK11 Protein, UFO Protein, AI323647 Protein, Ark Protein, Tyro7 Protein, Ufo Protein, AXL receptor tyrosine kinase Protein, Axl receptor tyrosine kinase Protein, AXL Protein, Axl Protein
- Sujet
- Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers.
- Poids moléculaire
- 72.6 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Tris-Bis PAGE result.
- Pathways
- Signalisation RTK, Cellular Response to Molecule of Bacterial Origin
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