TNFSF9 Protein (AA 68-251) (Fc Tag)
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- Antigène Voir toutes TNFSF9 Protéines
- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 68-251
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Origine
- Cynomolgus
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette TNFSF9 protéine est marqué à la Fc Tag.
- Fonction
- Cynomolgus 4-1BB Ligand/TNFSF9 Protein
- Séquence
- Arg68-Glu251
- Attributs du produit
- Recombinant Cynomolgus 4-1BB Ligand/TNFSF9 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Arg68-Glu251.
- Pureté
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Cynomolgus/Rhesus macaque 4-1BB, hFc Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Cynomolgus 4-1BB Ligand, hFc Tag with the EC50 of 6.7ng/ml determined by ELISA. See testing image for detail.
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- Discover our top product TNFSF9 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
- Autre désignation
- 4-1BB Ligand (TNFSF9 Produits)
- Synonymes
- TNFSF9 Protein, 4-1BB-L Protein, 4-1BBL Protein, AI848817 Protein, Cd137l Protein, Ly63l Protein, CD137L Protein, TNF superfamily member 9 Protein, tumor necrosis factor (ligand) superfamily, member 9 Protein, Tnfsf9 Protein, LOC476729 Protein, TNFSF9 Protein
- Sujet
- The 4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. 4-1BB ligand (4-1BBL) is an inducible molecule present on several APC types, including B cells, macrophages and DCs.4-1BB:4-1BBL pathway seems to amplify the existing costimulatory signals, even if the engagement of 4-1BB in the presence of a strong TCR signaling can induce IL-2 production in a CD28-independent manner.
- Poids moléculaire
- 46 kDa. Due to glycosylation, the protein migrates to 50-52 kDa based on Tris-Bis PAGE result.
- NCBI Accession
- XP_015296398
- Pathways
- Activated T Cell Proliferation, Cancer Immune Checkpoints
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