TNFSF9 Protein (Trimer) (Fc Tag)
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- Antigène Voir toutes TNFSF9 Protéines
- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
- Type de proteíne
- Recombinant
- Attributs du protein
- Trimer
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette TNFSF9 protéine est marqué à la Fc Tag.
- Fonction
- Human 4-1BB Ligand/TNFSF9 Trimer Protein
- Séquence
- Arg71-Glu254
- Attributs du produit
- Recombinant Human 4-1BB Ligand/TNFSF9 Trimer Protein is expressed from HEK293 with monomeric hFc tag at the N-Terminus.It contains Arg71-Glu254.
- Pureté
- > 95 % as determined by Tris-Bis PAGE
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human 4-1BB, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Human 4-1BB Ligand Trimer, hFc Tag with the EC50 of 5.7ng/ml determined by ELISA. See testing image for detail.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
- Autre désignation
- 4-1BB Ligand (TNFSF9 Produits)
- Synonymes
- TNFSF9 Protein, 4-1BB-L Protein, 4-1BBL Protein, AI848817 Protein, Cd137l Protein, Ly63l Protein, CD137L Protein, TNF superfamily member 9 Protein, tumor necrosis factor (ligand) superfamily, member 9 Protein, Tnfsf9 Protein, LOC476729 Protein, TNFSF9 Protein
- Sujet
- The 4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. 4-1BB ligand (4-1BBL) is an inducible molecule present on several APC types, including B cells, macrophages and DCs.4-1BB:4-1BBL pathway seems to amplify the existing costimulatory signals, even if the engagement of 4-1BB in the presence of a strong TCR signaling can induce IL-2 production in a CD28-independent manner.
- Poids moléculaire
- 84.3 kDa same as Tris-Bis PAGE result.
- UniProt
- P41273
- Pathways
- Activated T Cell Proliferation, Cancer Immune Checkpoints
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