KREMEN1 Protein (AA 21-392) (Fc Tag)

N° du produit ABIN7275107

Détail du produit

Antigène: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Type de proteíne: Recombinant

Attributs du protein: AA 21-392

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette KREMEN1 protéine est marqué à la Fc Tag.

Fonction: Human Kremen-1 Protein

Séquence: Arg21-Thr392

Attributs du produit: Recombinant Human Kremen-1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Arg21-Thr392.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Autre désignation: Kremen-1 (KREMEN1 Produits)

Synonymes: KREMEN1 Protein, krm1 Protein, kremen Protein, kremem1 Protein, KREMEN Protein, KRM1 Protein, AV002070 Protein, Kremen Protein, Krm1 Protein, si:ct737139.1 Protein, si:dkeyp-7c9.1 Protein, kringle containing transmembrane protein 1 Protein, kringle containing transmembrane protein 1 S homeolog Protein, KREMEN1 Protein, kremen1 Protein, Kremen1 Protein, kremen1.S Protein

Sujet: KREMEN1 (KRM1) has been identified as a functional receptor for Coxsackievirus A10 (CV-A10), a causative agent of hand-foot-and-mouth disease (HFMD), which poses a great threat to infants globally. KRM1 selectively binds to the mature viral particle above the canyon of the viral protein 1 (VP1) subunit and contacts across two adjacent asymmetry units. The key residues for receptor binding are conserved among most KRM1-dependent enteroviruses, suggesting a uniform mechanism for receptor binding.

Poids moléculaire: 67.6 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Tris-Bis PAGE result.

Pathways: Signalisation WNT