Mesothelin Protein (MSLN) (AA 296-580) (Fc Tag)

N° du produit ABIN7275283

Détail du produit

Antigène: Mesothelin (MSLN)

Type de proteíne: Recombinant

Attributs du protein: AA 296-580

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Mesothelin protéine est marqué à la Fc Tag.

Fonction: Human MSLN/Mesothelin Protein

Séquence: Glu296-Gly580

Attributs du produit: Recombinant Human MSLN/Mesothelin Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu296-Gly580.

Pureté: > 95 % as determined by Tris-Bis PAGE

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human MSLN at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Anti-MSLN Antibody, hFc Tag with the EC50 of 29.2ng/ml determined by ELISA. See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Mesothelin (MSLN)

Autre désignation: MSLN (MSLN Produits)

Synonymes: MPF Protein, SMRP Protein, MSLN Protein, mesothelin Protein, MSLN Protein, Msln Protein, LOC611363 Protein, LOC100524016 Protein

Sujet: Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31- kDa shed fragment named megakaryocyte-potentiating factor (MPF). Although it has been proposed that mesothelin may be involved in cell adhesion, its biological function is not known.A knockout mouse line that lacks mesothelin reproduces and develops normally.

Poids moléculaire: 59 kDa. Due to glycosylation, the protein migrates to 68-78 kDa based on Tris-Bis PAGE result.

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process