Oncostatin M Protein (OSM) (AA 25-206) (His tag)

N° du produit ABIN7275386

Détail du produit

Antigène: Oncostatin M (OSM)

Type de proteíne: Recombinant

Attributs du protein: AA 25-206

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette Oncostatin M protéine est marqué à la His tag.

Fonction: Mouse Oncostatin M/OSM Protein

Séquence: Asn25-Arg206

Attributs du produit: Recombinant Mouse Oncostatin M/OSM Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asn25-Arg206.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Oncostatin M (OSM)

Autre désignation: Oncostatin M (OSM Produits)

Synonymes: OSM Protein, OncoM Protein, oncostatin M Protein, OSM Protein, Osm Protein

Sujet: OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.

Poids moléculaire: 21.64 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.

UniProt: P53347

Pathways: Signalistation JAK/STAT, Negative Regulation of Hormone Secretion