JAG1 Protein (AA 34-1046) (His tag)

N° du produit ABIN7454157

Détail du produit

Antigène: JAG1 (Jagged 1 (JAG1))

Type de proteíne: Recombinant

Attributs du protein: AA 34-1046

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette JAG1 protéine est marqué à la His tag.

Fonction: Human Jagged 1/JAG1 Protein

Séquence: Gln34-Ser1046

Attributs du produit: Recombinant Human Jagged 1/JAG1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln34-Ser1046.

Pureté: > 95 % as determined by Tris-Bis PAGE

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: JAG1 (Jagged 1 (JAG1))

Autre désignation: Jagged 1 (JAG1 Produits)

Synonymes: AGS Protein, AHD Protein, AWS Protein, CD339 Protein, HJ1 Protein, JAGL1 Protein, ABE2 Protein, Gsfabe2 Protein, Htu Protein, Ozz Protein, Ser-1 Protein, JAG1 Protein, jag3 Protein, cb243 Protein, jag1 Protein, sb:cb243 Protein, serrateC Protein, jagged1 Protein, serrate Protein, serrate-1 Protein, x-serrate-1 Protein, jagged 1 Protein, jagged 1b Protein, jagged 1a Protein, jagged 1 L homeolog Protein, JAG1 Protein, Jag1 Protein, jag1 Protein, jag1b Protein, jag1a Protein, jag1.L Protein

Sujet: JAGGED1 (JAG1) is composed of a relatively small intracellular domain, a transmembrane domain and a larger extracellular component. JAG1 is widely expressed throughout mammalian development, across many tissues and developmental stages. The Notch signaling pathway and JAG1 in particular have been implicated in multiple forms of cancer and multiple aspects of cancer biology including tumor angiogenesis, neoplastic cell growth, cancer stem cell maintenance and the metastatic process.

Poids moléculaire: 111.56 kDa. Due to glycosylation, the protein migrates to 120-140 kDa based on Tris-Bis PAGE result.

Pathways: Signalisation Notch, Stem Cell Maintenance