FURIN Protein (His tag)

N° du produit ABIN7491211

Détail du produit

Antigène: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette FURIN protéine est marqué à la His tag.

Fonction: Recombinant human FURIN protein with C-terminal 6xHis tag

Specificité: FURIN (Gln27-Ala574) 6xHis tag

Attributs du produit: Extracellular Domain Protein

Pureté: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Autre désignation: FURIN (FURIN Produits)

Synonymes: FURIN Protein, furin Protein, si:dkey-281a24.5 Protein, FUR Protein, LOC100220259 Protein, PACE Protein, spc1 Protein, xfurin Protein, MGC82710 Protein, PCSK3 Protein, SPC1 Protein, 9130404I01Rik Protein, Fur Protein, Pcsk3 Protein, Pace Protein, furin, paired basic amino acid cleaving enzyme Protein, furin (paired basic amino acid cleaving enzyme) a Protein, furin (paired basic amino acid cleaving enzyme) b Protein, furin, paired basic amino acid cleaving enzyme L homeolog Protein, furin (paired basic amino acid cleaving enzyme) Protein, FURIN Protein, furina Protein, furinb Protein, furin Protein, furin.L Protein, Furin Protein

Sujet: FUR, PACE, PCSK3, SPC1
Description: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]

Poids moléculaire: predicted molecular mass of 61.0 kDa after removal of the signal peptide. The apparent molecular mass of FURIN-His is 55-70 kDa due to glycosylation.

UniProt: P09958

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway