IL-2 R beta & IL-2 R alpha & IL-2 R gamma protein (His tag,Twin-Strep tag)

N° du produit ABIN7488867

Détail du produit

Antigène: IL-2 R beta & IL-2 R alpha & IL-2 R gamma

Type de proteíne: Recombinant

Origine: Cynomolgus

Source: HEK-293 Cells

Purification/Conjugué: His tag,Twin-Strep tag

Fonction: Cynomolgus IL-2 R beta&IL-2 R alpha&IL-2 R gamma Protein, His Tag&Twin-Strep Tag (MALS verified)

Séquence: Glu 22 - Glu 213 & Leu 23 - Pro 255

Attributs du produit: Cynomolgus IL-2RB&IL-2RA&IL-2RG Protein, His Tag&Twin-Strep Tag is expressed from human 293 cells (HEK293). It contains AA Glu 22 - Glu 213 & Leu 23 - Pro 255 (Accession # Q38J85-1 & H6WS54 & Q38JL2-1).

Pureté: 95 %

niveau d'endotoxine: 1.0 EU per μg

Classe de qualité: MALS verified

Information d'application

Commentaires:

Cynomolgus IL-2RB&IL-2RA&IL-2RG, His Tag&Twin-Strep Tag is produced by co-expression of IL-2RB and IL-2RA and IL-2RG, has a calculated MW of 30. (10xHis | Twin-Strep) 1 kDa (IL-2RB) and 55.9 kDa (IL-2RA&IL-2RG). Subunit IL-2RB is fused with a his tag at the C-terminus and subunit IL-2RA&IL-2RG is fused with a Twin-Strep Tag at the C-terminus. The reducing (R) protein migrates as 37-44 kDa and 85-100 kDa respectively due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: IL-2 R beta & IL-2 R alpha & IL-2 R gamma

Autre désignation: IL-2 R beta&IL-2 R alpha&IL-2 R gamma

Sujet: Both Interleukin-2 receptor subunit beta and Interleukin-2 receptor subunit gamma are receptor for interleukin-2. Common subunit for the receptors for a variety of interleukins. Interacts with SHB upon interleukin stimulation. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

Poids moléculaire: 30.1 kDa | 55.9 kDa