FZD7 Protein (Fc Tag,His tag)

N° du produit ABIN7534242

Détail du produit

Antigène: FZD7 (Frizzled Family Receptor 7 (FZD7))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette FZD7 protéine est marqué à la Fc Tag,His tag.

Fonction: Active Recombinant Human Frizzled-7/FZD7 Protein

Séquence: QPYHGEKGIS VPDHGFCQPI SIPLCTDIAY NQTILPNLLG HTNQEDAGLE VHQFYPLVKV QCSPELRFFL CSMYAPVCTV LDQAIPPCRS LCERARQGCE ALMNKFGFQW PERLRCENFP VHGAGEICVG QNTSDGSGGP GGGPTAYPTA PYL

Specificité: Gln33-Leu185

Pureté: > 95 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: < 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment: 1.Measured by its binding ability in a functional ELISA. Immobilized Human Glypican-3 Protein at 5 μg/mL (100 μL/well) can bind Human FZD7 with a linear range of 4.88-935.5 ng/mL.|2.Measured by its binding ability in a functional ELISA. Immobilized Human Glypican-3 Protein at 5 μg/mL (100 μL/well) can bind Human FZD7 with a linear range of 4.88-520.4 ng/mL.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Détail du antigène

Antigène: FZD7 (Frizzled Family Receptor 7 (FZD7))

Autre désignation: Frizzled-7/FZD7 (FZD7 Produits)

Synonymes: FzE3 Protein, Fz-7 Protein, Xfz7 Protein, frizzled-7 Protein, frizzled7 Protein, frz-7 Protein, frz7 Protein, fz7 Protein, fzd7-a Protein, fzd7-b Protein, fze3 Protein, Fz7 Protein, cFz-7 Protein, fb38g02 Protein, fc44b09 Protein, fz13 Protein, fz7a Protein, fz7b Protein, wu:fb38g02 Protein, wu:fc44b09 Protein, zg13 Protein, frizzled class receptor 7 Protein, frizzled class receptor 7 L homeolog Protein, frizzled class receptor 7b Protein, FZD7 Protein, fzd7.L Protein, fzd7 Protein, Fzd7 Protein, fzd7b Protein

Sujet:

Description: Frizzled-7 is a member of the Frizzled family of unconventional G-protein-coupled glycoprotein receptors for the Wnt signaling pathway. During development, Frizzled-7 is expressed during gastrulation and in the fetal gut, kidney and lung where it is thought to influence tissue morphogenesis via non-canonical signaling pathways . In the adult, Frizzled-7 is expressed in skeletal muscle, especially in satellite cells that mediate muscle regeneration in response to Wnt-7a. It is expressed in embryonic stem cells (ES), contributing to self-renewal signaling . Frizzled-7 expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

Name: FZD7,FzE3

ID gène: 8324

UniProt: O75084

Pathways: Signalisation WNT, Stem Cell Maintenance