NFKBIA Protéine
-
- Antigène Voir toutes NFKBIA Protéines
- NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
-
Origine
- Humain
-
Source
- Escherichia coli (E. coli)
- Fonction
- Active Recombinant Human IkB-alpha/NFKBIA Protein
- Séquence
- FQAAERPQEW AMEGPRDGLK KERLLDDRHD SGLDSMKDEE YEQMVKELQE IRLEPQEVPR GSEPWKQQLT EDGDSFLHLA IIHEEKALTM EVIRQVKGDL AFLNFQNNLQ QTPLHLAVIT NQPEIAEALL GAGCDPELRD FRGNTPLHLA CEQGCLASVG VLTQSCTTPH LHSILKATNY NGHTCLHLAS IHGYLGIVEL LVSLGADVNA QEPCNGRTAL HLAVDLQNPD LVSLLLKCGA DVNRVTYQGY SPYQLTWGRP STRIQQQLGQ LTLENLQMLP ESEDEESYDT ESEFTEFTED ELPYDDCVFG GQRLTL
- Specificité
- Phe2-Leu317
- Pureté
- > 90 % by SDS-PAGE.
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- < 1.0 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized Human IkB-alpha Protein at 2 μg/mL (100 μL/well) can bind IκBα Rabbit mAb with a linear range of 0.195-0.64 ng/mL.
- Top Product
- Discover our top product NFKBIA Protéine
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- Buffer
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
-
Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
-
- Antigène
- NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))
- Autre désignation
- IkB-alpha/NFKBIA (NFKBIA Produits)
- Synonymes
- IKBA Protein, MAD-3 Protein, NFKBI Protein, AI462015 Protein, Nfkbi Protein, RL/IF-1 Protein, ECI-6/IKBA Protein, NFKBIA Protein, ikbaB Protein, wu:fb81f08 Protein, zgc:56666 Protein, zgc:77616 Protein, ikbaA Protein, wu:fj16a07 Protein, zgc:85769 Protein, NFKB inhibitor alpha Protein, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b Protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a Protein, NFKBIA Protein, Nfkbia Protein, nfkbiab Protein, nfkbiaa Protein
- Sujet
-
Description: This protein is a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The protein is interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
Name: IKBA, MAD-3, NFKBI,NFKBIA,MAD-3,NFKBI,IKB alpha,EDAID2, IKBA, NFKB inhibitor alpha
- ID gène
- 4792
- UniProt
- P25963
- Pathways
- Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling
-