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IL-15 Protéine

IL15 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 96 % by SDS-PAGE and HPLC analyses. Active
N° du produit ABIN871794
  • Antigène Voir toutes IL-15 (IL15) Protéines
    IL-15 (IL15) (Interleukin 15 (IL15))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 22
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Source
    • 33
    • 10
    • 10
    • 2
    • 2
    Escherichia coli (E. coli)
    Séquence
    MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
    Pureté
    > 96 % by SDS-PAGE and HPLC analyses.
    Stérilité
    0.2 μm filtered
    niveau d'endotoxine
    Less than 1EU/µg of rHuIL-15 as determined by LAL method.
    Top Product
    Discover our top product IL15 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20° C. Further dilutions should be made in appropriate buffered solutions.
    Stock
    4 °C/-20 °C
  • Antigène
    IL-15 (IL15) (Interleukin 15 (IL15))
    Autre désignation
    IL-15 (IL15 Produits)
    Synonymes
    IL15 Protein, AI503618 Protein, IL-15 Protein, interleukin 15 Protein, IL15 Protein, Il15 Protein
    Sujet
    Interleukin 15 is a recently identified novel cytokine that shares many biological properties with IL-2, including T, B and NK cell-stimulatory activities. cDNA clones encoding this cytokine have been isolated from simian, murine and human cell sources. Human IL-15 shares approximately 97% and 73% sequence identity with simian and murine IL-15, respectively. Both human and simian IL-15 are active on murine cells. Human IL-15 cDNA encodes a 162 amino acid residue precursor protein containing a 48 amino acid residue signal peptide that is cleaved to yield the 114 amino acid residue mature protein. The IL-15 mRNA is expressed by a wide variety of cells and tissues and is most abundantly expressed by adherent peripheral blood mononuclear cells, fibroblasts and epithelial cells. However, in activated peripheral blood T lymphocytes where IL-2 is highly expressed, the expression of IL-15 is not detectable. Although IL-15 lacks sequence homology with IL-2, it has recently been shown that both the beta and gamma chains of the IL-2 receptor are utilized for IL-15 binding and signaling. In addition, an IL-15 specific binding protein has also been cloned from a mouse T cell clone. (Grabstein, K. et al., 1994, Science 264:965, Giri, J. et al., 1994, EMBO J. 13:2822).
    Pathways
    Signalistation JAK/STAT, Glycosaminoglycan Metabolic Process
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