TNFRSF10B Protein (AA 52-212) (Fc Tag)

N° du produit ABIN925132

Détail du produit

Antigène: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Type de proteíne: Recombinant

Attributs du protein: AA 52-212

Origine: Humain

Source: HEK-293T Cells

Purification/Conjugué: Cette TNFRSF10B protéine est marqué à la Fc Tag.

Application: ELISA

Specificité: Binds human and mouse TRAIL. Other species not tested.

Attributs du produit: Inhibits soluble TRAIL-induced apoptosis in a concentration range of 0.5-10 µg/mL. Concentrations of rhTRAIL-R2:Fc required to inhibit may vary depending on the cell type studied and on the concentration of sTRAIL used to kill cells. The extracellular domain (AA 52-212) of human TRAIL-R2 fused to the Fc portion of human IgG1.

Purification: Purified protein (LAL).

Pureté: 95 % as determined by SDS-PAGE.

Information d'application

Indications d'application: ELISA: Use at 1 µg/mL. (capture)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Stock: -20 °C

Détail du antigène

Antigène: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Autre désignation: TRAIL-R2 (TNFRSF10B Produits)

Synonymes: TNFRSF10B Protein, dr5 Protein, cd262 Protein, killer Protein, trick2 Protein, trickb Protein, xDR-M1 Protein, xDR-M2 Protein, ztnfr9 Protein, trailr2 Protein, trick2a Protein, trick2b Protein, CD262 Protein, DR5 Protein, KILLER Protein, KILLER/DR5 Protein, TRAIL-R2 Protein, TRAILR2 Protein, TRICK2 Protein, TRICK2A Protein, TRICK2B Protein, TRICKB Protein, ZTNFR9 Protein, Ly98 Protein, MK Protein, tumor necrosis factor receptor superfamily, member 10b Protein, tumor necrosis factor receptor superfamily member 10b S homeolog Protein, tumor necrosis factor receptor superfamily member 10b L homeolog Protein, tumor necrosis factor receptor superfamily member 10b Protein, TNF receptor superfamily member 10b Protein, Tnfrsf10b Protein, TNFRSF10B Protein, tnfrsf10b.S Protein, tnfrsf10b.L Protein, tnfrsf10b Protein

Sujet: TRAIL receptors are members of the TNF family of proteins. TRAIL-R2 (DR5) is a 50 kDa transmembrane protein containing 2 cysteine- rich repeats in the extracellular portion and a cytoplasmic motif called a `death domain' (DD). Binding of TRAIL (APO-2L) to TRAIL-R2 can induce apoptosis. Other identified TRAIL receptors include TRAIL-R1 (DR4), which like TRAIL-R2 promotes apoptosis, and three receptors (TRAIL-R3, TRAIL-R4, and Osteoprotegerin) that are inhibitory. Synonyms: DR5, KILLER, TNFRSF 10B, CD262

Poids moléculaire: ~46 kDa (SDS-PAGE)

Pathways: Signalisation p53, Apoptose, Positive Regulation of Endopeptidase Activity