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anti-Human CXCL12 Anticorps:
anti-Mouse (Murine) CXCL12 Anticorps:
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Human Monoclonal CXCL12 Primary Antibody pour CyTOF, ELISA (Capture) - ABIN4899704
Villalba, Salvucci, Aoki, De La Luz Sierra, Gupta, Davis, Wyvill, Little, Yarchoan, Tosato: Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo. dans Journal of leukocyte biology 2003
Show all 39 Pubmed References
Mouse (Murine) Polyclonal CXCL12 Primary Antibody pour WB - ABIN5518981
Zhang, Qi, Li, Zhang, Xu, Wang, Sun: Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer. dans Journal of experimental & clinical cancer research : CR 2009
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Human Monoclonal CXCL12 Primary Antibody pour FACS - ABIN4896548
Hoellenriegel, Zboralski, Maasch, Rosin, Wierda, Keating, Kruschinski, Burger: The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization. dans Blood 2014
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Human Polyclonal CXCL12 Primary Antibody pour WB - ABIN223587
Kondo, Shintani, Shibata, Murakami, Murakami, Imaizumi, Kitagawa, Murohara: Implantation of adipose-derived regenerative cells enhances ischemia-induced angiogenesis. dans Arteriosclerosis, thrombosis, and vascular biology 2008
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Human Polyclonal CXCL12 Primary Antibody pour IF (p), IHC (p) - ABIN1386329
Pei, Zeng, Han, Liao, Zhou, Li, Zhang, Liu, Zhang, Liu, Yao, Xu: Renal interstitial infiltration and tertiary lymphoid organ neogenesis in IgA nephropathy. dans Clinical journal of the American Society of Nephrology : CJASN 2014
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Human Polyclonal CXCL12 Primary Antibody pour ELISA, Func - ABIN4301060
Nistala, Habibi, Aroor, Sowers, Hayden, Meuth, Knight, Hancock, Klein, DeMarco, Whaley-Connell: DPP4 inhibition attenuates filtration barrier injury and oxidant stress in the zucker obese rat. dans Obesity (Silver Spring, Md.) 2014
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Cow (Bovine) Polyclonal CXCL12 Primary Antibody pour WB - ABIN2774605
Sadir, Imberty, Baleux, Lortat-Jacob: Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV. dans The Journal of biological chemistry 2004
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Mouse (Murine) Polyclonal CXCL12 Primary Antibody pour IHC (fro), IP - ABIN550028
Chadwick, Boyle, Zhou, Wang, Park, Martin, Wang, Becker, Wood, Zhang, Peers, Maudsley: Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. dans PLoS ONE 2011
Human Polyclonal CXCL12 Primary Antibody pour ELISA, IHC - ABIN6264954
Wang, Wang, Gao, Zhang, Lou, Jin, Chen, Lei, Xu, Mao: Highly efficient local delivery of endothelial progenitor cells significantly potentiates angiogenesis and full-thickness wound healing. dans Acta biomaterialia 2018
we found that miR-101 is markedly downregulated and inversely associated with CXCL12 expression in PTC tissues and cells. Clinically, miR-101 downregulation is positively associated with advanced histological stages and lymph node and distant metastases.
This is associated with a significant shift in response to SDF1 in ASCs with amplified ERK1/2 activation, growth factor-like immediate early gene regulation and EGR1 protein expression.
CXCL12 was significantly more expressed in liver metastasis than in primary intrahepatic cholangiocarcinoma. Patients with high CXCL12 expression showed significant poor prognosis in terms of disease-free and overall survival. These results provide evidence that CXCL12 might be associated with metastasis and poor prognosis in intrahepatic cholangiocarcinoma.
CXCL12 serum levels were significantly higher in Parkinson disease patients compared to controls.
Data show that stromal cell-derived factor-1 (CXCL12) and chemokine (C-X-C motif) receptor 4 (CXCR4) are expressed simultaneously in colorectal carcinoma tissues, suggesting that expression of these chemokines and corresponding receptors may play a pivotal role in colorectal tumorigenesis.
CXCR4 and CXCL12 expression is significantly increased in both stable and unstable carotid atherosclerotic plaques compared with healthy vessels, both at mRNA and protein level
The results of these studies show that activation of the CXCL12/CXCR4 axis uniquely facilitates procollagen I secretion through a COPII-vesicle mediated mechanism to promote production of the ECM characteristic of fibrosis
Elevated CXCL12 levels were identified as a causal risk factor for Coronary Artery Disease with consistent epidemiological results. Furthermore, genetically predicted CXCL12 levels were associated with CAD in the UK Biobank.
CXCL12 regulation plays a significant role in both tumor progression.
Conclusion Both dominant and additive models in both KCNJ11 (E23K, rs5219) and SDF-1b (G801A, rs1801157) genetic polymorphisms are significantly associated with type 2 diabetes
the present study indicated that CXCL12 rs1801177 and CXCR4 rs2228014 are not associated with triple negative breast cancer development in isolation, but might increase triple negative breast cancer susceptibility in combination. Also, CXCL12 polymorphism was negatively correlated with Ki67 staining.
Expression of CXCL12gamma induces the expression of a cancer stem cell and neuroendocrine phenotypes, resulting in the development of aggressive metastatic castration-resistant prostate cancer
High CXCL12 expression is associated with epithelial-mesenchymal transition in ovarian cancer.
Study suggests that SDF-1 G>A and CXCR4 C>T polymorphism plays a role in the development of oral squamous cell carcinoma (OSCC) and oral and pharyngeal squamous cell carcinoma (OPSCC). However, the combination of SDF-1 G>A and CXCR4 C>T did not correlate with OPSCC risk, except for OSCC.
Upregulation of SDF1 is associated with Angiogenesis in Degenerated Discs.
Gene polymorphism of CXCL12 rs2297630 is associated with the genetic risk of CAD and the severity of coronary stenosis
the data indicated that miR31 promoted chondrocyte viability and migration by directly targeting CXCL12, which provided evidence for CXCL12 as a potential target in osteoarthritis therapy.
The results suggested that cartilage endplate stem cells might promote nucleus pulposus cells proliferation in a paracrine pathway, which was partially mediated by SDF-1/CXCR4 axis via ERK1/ERK2 signaling transduction pathway.
SDF-1 can induce metastatic squamous cell carcinoma of the head and neck (SCCHN) by integrin alphanubeta3-CXC chemokine receptor (CXCR) 4/CXCR7 axi. LM609, AMD3100, and CCX754 and can reduce the regulation of SDF-1 on SCCHN activity.
our study confirmed that CXCL12 can enhance the angiogenesis potential of PDLSCs, which are crucial in the repair and regeneration of bone tissue.
these results demonstrate that a cross-talk exists between the TGF-beta1 and SDF-1 pathways in choroid-retinal endothelial cells
following optic nerve crush, the levels of endogenous SDF-1alpha and CXCR4 increase in the retina and optic nerve, where activated glial cells may act as a source of increased SDF-1alpha protein.
The CXCR7/CXCR4/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
SDF-1 expression in cancer associated fibroblasts is under the control of ATF3 and JDP2.
study reveals a previously unidentified role of the MSPC-secreting Cxcl12 that regulates its osteogenesis and adipogenesis through the cell-autonomous and non-autonomous mechanism, respectively; which could further influence the homeostatic control of the hematopoietic system.
Receptor-Ligand Interaction Mediates Targeting of Endothelial Colony Forming Cell-derived Exosomes to the Kidney after Ischemic Injury
nitration of CXCL12 occurs readily upon contact with peroxynitrite and specifically nitration of Tyr7 fully reduces its in vitro and in vivo biological activities.
Our results suggest that CXCL12 enhances lipopolysaccharide-induced osteoclastogenesis and bone resorption in vivo
a new mechanism where CXCL12-signals from granule neurons prevent dispersion and support maturation of newborn granule neurons
concluded that SDF-1/CXCR4 pathway improved diabetic retinopathy possibly by increasing cell viability
findings suggest that CXCL12/CXCR4 signaling contributes to hypernociception after chronic compression of dorsal root ganglia
Migration of iPSCs activated by CXCL12 is associated with significant phosphorylation of AKT
Study indicated that the up-regulated expression of CXCL12 in IFN-gamma induced abortion mouse uteri was not directly the responding of the administration of IFN-gamma. The up-regulated expression of CXCL12 in the later stage of aborted mouse uteri played an anti-inflammatory role that involves in the process of endometrial restoration after abortion.
AnnexinA7 positively regulates expression levels of SDF1/CXCR4
tested for possible epistasis between Tbx1 and the CXCL12 signalling axis by examining Tbx1 and Cxcl12 double heterozygotes as well as Tbx1/Cxcl12/Cxcr4 triple heterozygotes, but failed to identify any exacerbation of the Tbx1 haploinsufficient arch artery phenotype
SDF-1/CXCR4 pathway may play an important role in fracture healing following bone mesenchymal stem cell transplantation.
Cross-talk between fibroblast-derived CXCL12 and endothelial cells could be used as novel biomarker.
these findings identify the CXCR4-CXCL12 axis as a potential therapeutic target likely due to its importance for antibody-secreting cell homing and survival
miR-342 is involved in MS-K tumor growth as a tumor suppressor by targeting chemokine CXCL12.
superparamagnetic iron oxide nanoparticles also stimulated CXCR4 (C-X-C chemokine receptor type 4) expression and CXCR4-SDF-1 (Stromal cell-derived factor 1) signaling in mesenchymal stem cells.
This study regarding high SDF-1 levels in our mouse model of ototoxicity would play a major role in the development of therapeutic agents using MSC homing.
CXCL12-CXCR4 signalling is essential for the correct patterning of aortic arches and pulmonary arteries during development.
Data (including data from studies in knockout mice) suggest that adipocyte autocrine function involving Sdf1 regulates insulin resistance; Sdf1 gene expression correlates with insulin-desensitized conditions in adipocytes but not other tissues (liver, skeletal muscle); adipocyte-specific ablation of Sdf1 enhances insulin sensitivity in adipose tissues and in whole body.
These findings support the conservation of sdf-1alpha signaling in vertebrate somite morphogenesis; however, the precise mechanism by which this signaling pathway influences somite morphogenesis is different between the fish and the frog.
expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7
SDF-1/CXCR4 chemokine signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus
A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls.
SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation.
These results suggest that CXCL12 may be critical for the establishment of pregnancy by regulating trophoblast migration and T cell recruitment into the endometrium during the implantation period in pigs.
Polymorphisms in CXCL12 are significantly associated with immunological traits in Landrace piglets and have potential application value for marker-assisted selection of pig breeding with disease resistance.
The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.
Findings indicate that stromal fibroblasts within mammary glands with mastitis contribute to EMT and inflammatory responses of epithelial cells through the secretion of SDF-1, which could result in the inflammation spread and fibrosis within mammary gland.
There is a potential link between follicular SDF1/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
Polymorphism of intron 2 of the SDF1 gene in Galloway, Hereford, and Russian Black Pied cattle
formulate a mathematical model of a laser ablated primordium separated into two smaller cell collectives: a leading collective that responds to local CXCL12a levels and a trailing collective that migrates up a local FGF gradient.
Cxcl12 and Myc facilitate glycolysis to promote fast migratory responses during development and repair during kidney injury and development
snail1b expression is initiated by chemokines first encountered by leading primordium cells and its expression plays a crucial role in initiating collective migration of the posterior lateral line primordium.
Study demonstrates that forced expression of Sdf1a in the fish embryo during early development is an effective strategy to disrupt primordial germ cell migration and produce large populations of infertile fish.
miR-126a directs lymphatic endothelial cell sprouting and extension by interacting with Cxcl12a-mediated chemokine signaling and Vegfc-Flt4 signal axis.
filopodia distribution and their dynamics are dictated by the gradient of the chemokine Cxcl12a.
Our data show that elevated concentrations of circulating CXCL12a in pulmonary hypertension predicted poorer survival
SDF1a directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7.
Prospective isolation and culture of sdf1(DsRed) perivascular cells demonstrated properties consistent with mesenchymal stem cells.
Study shows that the primordium generates an attractant gradient across itself by sequestering Sdf1a protein in its rear via Cxcr7-mediated chemokine uptake. This self-generated attractant gradient, combined with the route information provided by the stripe of sdf1a-expressing cells, then provides directional guidance to the migrating primordium.
gata4 gene regulates sdf1a levels during early embryogenesis
These findings suggest an "attractive path" model in which migrating cells closely follow a dynamic SDF1a source that is refined on a transcript and protein level by miR-430 and Cxcr7b, respectively.
sdf-1 expression and function in the adult zebrafish have important similarities to mammals
Expression of Cxcl12 and Cxclr4 in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12/Cxcr4 pair in brain development and functioning.
A single amino acid exchange switches the relative affinity of the Cxcl12 ligands for one of the duplicated Cxcr4 receptors, thereby determining the functional specialization of each chemokine that elicits a distinct function in a distinct process.
we demonstrate that miR-430-mediated regulation of endogenous sdf1a and cxcr7b facilitates dynamic expression of sdf1a by clearing its mRNA from previous expression domains.
Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.
A trail of SDF1-like chemokine encoded by the sdf1a gene is present along the pathway of the lateral line primordium. Both the formation and the innervation of this system depend on the SDF1-CXCR4 system
SDF1/CXCR4-mediated cell migration is preferentially associated with movement along the anteroposterior axis of the animal
SDF-1/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.
This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.
intercrine reduced in hepatomas
, pre-B cell growth-stimulating factor
, stromal cell-derived factor 1
, chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
, chemokine CXCL12/SDF-1ALPHA
, stromal cell-derived factor 1 isoform alpha
, stromal cell-derived factor 1 isoform gamma
, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1
, pre-B-cell growth-stimulating factor
, thymic lymphoma cell-stimulating factor
, SDF-1 gamma
, Stromal cell-derived factor 1
, stromal cell-derived factor-1 gamma
, C-X-C motif chemokine 12
, stromal-derived factor 1
, chemokine ligand 12b
, stromal cell derived factor 1
, stromal cell-derived factor-1 beta
, CXC chemokine
, CXCL12 chemokine
, chemokine ligand 12
, unm t30516