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Overall five-year biochemical recurrence (BCR)-free survival rates in the group with decreased BMP-2 expression were worse than those in the group with normal expression. Therefore, decreased BMP-2 expression in prostate cancer tissue was correlated with the prognostic factors for BCR-free survival in patients with prostate cancer.
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after 12 weeks, the bone volume induced by co-delivery of BMP-2 and IL-17 was doubled as compared to that induced by BMP-2 alone...The use of IL-17 may contribute to the development of improved bone graft substitutes.
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Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling.
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Cell-permeable SBD peptide blocked the association of p65 with Smad4 and enhanced BMP2-induced osteoblast differentiation and mineralization.
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Variability in the BMP2 and DLX3 genes was not associated with dental caries in primary and permanent dentition in Czech children
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TAK1 up regulates the expression of BMP-2 at all concentration under the inhibition of p38 and JNK.
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we find the presence of a methylation site at - 267th nucleotide position in the BMP2 promoter of Asian Indian population. This methylation site in the promoter region of BMP2 suppresses gene expression in osteoporosis. 14 CpG sites in the BMP2 promoter were analyzed of which, CpG site at - 267th position upstream to TSS was found to have disproportionate allele frequency among osteoporotic and healthy individuals.
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Mechanistically, SOX9 bound directly to the promoter region of BMP2 and increased BMP2 expression. In addition, overexpression of SOX9 activated the mTOR pathway partly through BMP2.
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IL-6 may be responsible for coformation of new bone and excessive adipose tissue in rhBMP-2-induced bone voids.
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BMP2 promotes trophoblast cell invasion by upregulating N-cadherin via non-canonical ALK2/3/4-SMAD2/3-SMAD4 signaling.
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BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPARgamma and GLUT4 upregulation
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BMP-2 is a driving factor for promoting epithelial mesenchymal transition and breast cancer stemness via Rb and CD44 signaling pathways
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Based on the results shown here, CGRP can mitigate augmenting effects of SP on BMP2 signaling and the three pathways potentially converge on Runx2 to regulate BMP2-induced bone differentiation.
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functional studies on NR2F1 transfected cells, during osteoblast differentiation in combination with TGFbeta1 and BMP-2, showed that TGFb1 does not recover osteoblast differentiation, whereas BMP-2 rescues osteoblast differentiation in NR2F1 siRNA transfected cells. Thus, our results showed that BMP-2 could intervene in NR2F1 down-regulated signaling pathways to recover osteoblast differentiation.
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BMP2 mutation c.393A>T (p. Arg131Ser) affects bone morphogenetic protein signaling activity
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This study demonstrated that Upregulation of bone morphogenetic protein 2 ( Bmp2) in dorsal root ganglion in a rat model of bone cancer pain.
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Hepatic bone morphogenetic protein 2 (BMP-2) was localized in parenchymal hepatocytes and significantly decreased in fibrotic livers, showing an opposite pattern of hepatic transforming growth factor-beta 1 (TGF-beta1) contents.
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BMP-2 could enhance migration and proliferation of hypoxia-induced VSMCs via the Actin/CD44/MMP-2 molecular pathway.
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KCNQ1OT1 positively regulated osteogenic differentiation of BMSCs by acting as a ceRNA to regulate BMP2 expression through sponging miR-214.
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BMP-2-treated adipose-derived stem cells exhibited higher BMP-2 production and greater osteogenic differentiation capacity compared to BMP-2-treated Bone-marrow stem cells .