Aperçu des produits pour BMP2 Protéines (BMP2)

Human Bone Morphogenetic Protein 2 (BMP2) interaction partners

1. conclude that SUMO3 (Montrer SUMO3 Protéines)-tagged hBMP2 is more suited for generation of soluble form of the protein and addition of SUMO3 (Montrer SUMO3 Protéines) tag does not affect the functional activity of hBMP2

2. The present study identified a change in miR (Montrer MLXIP Protéines)-22, miR (Montrer MLXIP Protéines)-140, and BMP-2 expression in the synovial fluid of patients with osteoarthritis before and after arthroscopic debridement.

3. The study revealed an enhanced sensitivity of aortic valve interstitial cells to osteogenic inductors in aortic stenosis patients, which indicates probable implication of OPN (Montrer SPP1 Protéines), OPG (Montrer TNFRSF11B Protéines), and BMP2 genes in pathogenesis of aortic valve calcification.

4. In contrast to BMP-2, BMP-7 (Montrer BMP7 Protéines) concomitantly inhibited the expression of profibrotic genes

5. The binding free energies indicate that ALK-3 (Montrer BMPR1A Protéines) preferably binds to BMP-2 instead of BMP-9 (Montrer GDF2 Protéines). The structural analysis shows that ALK-3 (Montrer BMPR1A Protéines) binding with BMP-2 occurs in a perfectly symmetry pathway, whereas this symmetry is lost for possible ALK-3 (Montrer BMPR1A Protéines) interactions with BMP-9 (Montrer GDF2 Protéines)

6. The results demonstrate the efficacy of HPP-GC hydrogel in minimizing the diffusive loss of rhBMP-2 from the implantation site, compared to the collagen hydroxyapatite scaffold.

7. The in vitro results suggest that altered BMP2 regulatory function at rs1884302 may contribute to the etiology of sagittal nonsyndromic craniosynostosis. The in vivo results indicate that differences in regulatory activity depend on the presence of a C or T allele at rs1884302.

8. Collectively, according to our study, rhIL-6 could induce the extracellular calcification and osteogenic differentiation of human artery smooth muscle cells through upregulating endogenous BMP2 in vitro. This may be one of the underlying mechanisms of the overwhelming vascular calcification in rheumartoid arthritis.

9. HUCB-MSC (Montrer MSC Protéines) transfected with mTAT/PEI were shown to express more BMP-2 protein and mRNA.

10. These results showed that BMP2 activated SMAD1 (Montrer GARS Protéines)/5/8 phosphorylation and up-regulated BAMBI (Montrer BAMBI Protéines) mRNA in human granulosa-lutein cells.

Mouse (Murine) Bone Morphogenetic Protein 2 (BMP2) interaction partners

1. widespread myocardial Bmp2 and endocardial Notch (Montrer NOTCH1 Protéines) signaling drive presumptive ventricular endocardium to differentiate into valve endocardium

2. BMP-2 can enhance HUVEC proliferation, migration and angiogenesis through P38, ERK and Akt/m-TOR pathway.

3. CTGF (Montrer CTGF Protéines) and BMP2 are induced following myocardial ischemia in mice and humans.

4. Results indicate that Notch (Montrer NOTCH1 Protéines) signaling induces cell cycle arrest and thereby initiates chondrocyte cell enlargement via bone morphogenetic protein 2 (BMP2) signaling.

5. Collectively, our findings indicate that CBFA2T2 (Montrer CBFA2T2 Protéines) is required for BMP-2-induced osteogenic differentiation of MSCs through inhibition of EHMT1 (Montrer EHMT1 Protéines)-mediated histone methylation at Runx2 (Montrer RUNX2 Protéines) promoter.

6. The data suggest that SDF-1beta provides synergistic effects supporting BMP-2-induced, BMSC-mediated bone formation and appears suitable for optimization of bone augmentation in combination therapy protocols.

7. study revealed that only BMP-6 (Montrer BMP6 Protéines) was able to induce bone formation at the used dose and that the addition of IGF-1 (Montrer IGF1 Protéines) contributed to an increase of the mineralization in the implants. Hence, the combination of BMP-6 (Montrer BMP6 Protéines) with IGF-1 (Montrer IGF1 Protéines) might be a better alternative than BMP-2 for orthopedic surgery or bone tissue engineering approaches.

8. BMP2 may induce osteogenic differentiation.

9. Increased bone mass in Crmp4 (Montrer DPYSL3 Protéines)(-/-) mice was associated with enhanced BMP2 signaling and BMP2-induced osteoblast differentiation in Crmp4 (Montrer DPYSL3 Protéines)(-/-) osteoblasts (OBs (Montrer LEP Protéines)).

10. Deletion of the "ultra-conserved sequence" within the 3'UTR of the Bmp2 was associated with elevated Bmp2 mRNA and BMP signaling levels, reduced fitness, and embryonic malformations.

Xenopus laevis Bone Morphogenetic Protein 2 (BMP2) interaction partners

1. Bone morphogenetic protein inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.

2. Bmp antagonists and morpholinos designed against Bmp4, Bmp2, and Bmp7 demonstrate that Bmp signaling is critical for ventral, but not dorsoanterior endoderm formation

Cow (Bovine) Bone Morphogenetic Protein 2 (BMP2) interaction partners

1. High BMP2 expression is associated with cystic ovarian disease.

2. both FSH (Montrer BRD2 Protéines) and BMP-2 reduced follicular mRNA expression of GDF9 (Montrer GDF9 Protéines) and NLRP5 when compared to follicles cultured in media containing only FSH (Montrer BRD2 Protéines)

3. The BMP2/4 (Montrer BMP4 Protéines) ligand and receptor system presides within bovine trophectoderm prior to uterine attachment.

4. concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than oocyte maturation

Rabbit Bone Morphogenetic Protein 2 (BMP2) interaction partners

1. The transfecting capability of a BMP-2 specific vector is examined and supports the idea that BMP-2 might diminish osseointegration and implant fixation.

2. While BMP2 expression begins at (pregastrulation) stage 1 in the hypoblast, BMP4 (Montrer BMP4 Protéines) expression commences--distinctly delayed compared to the mouse--diffusely at (pregastrulation) stage 2; from stage 3 onwards.

3. Maxillary sinus floor elevation using BMP-2 gene-modified bone marrow stromal cells and TCP in rabbits

4. Data show that BMP-2, BMP-4 (Montrer BMP4 Protéines), and BMP-7 (Montrer BMP7 Protéines), noggin (Montrer NOG Protéines), and chordin (Montrer CHRD Protéines) were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.

5. BMP2 is not suitable to regenerate osteochondral lesions completely

Pig (Porcine) Bone Morphogenetic Protein 2 (BMP2) interaction partners

1. High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-beta1 (Montrer TGFB1 Protéines).

2. Report temporal regulation of BMP2 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.

3. Regional variation of periosteal activity at the mandibular ramus is regulated by differential induction of BMP2.

4. The effects of soy- and cow's milk-based formulas compared to nursing on bone development through BMP2 expression in neonatal pigs are reported.

Horse (Equine) Bone Morphogenetic Protein 2 (BMP2) interaction partners

1. The effect of bone morphogenetic protein (BMP) 12 and BMP2 expression on differentiation of bone marrow-derived mesenchymal stem cells and superficial digital flexor tenocytes is reported.

Zebrafish Bone Morphogenetic Protein 2 (BMP2) interaction partners

1. Study found that BMP-2 (Montrer BMP4 Protéines) is negatively regulated by miR (Montrer MYLIP Protéines)-140 during early embryogenesis and bone development in zebra fi sh.

2. Structures of Bmp2a, Bmp2b (Montrer BMP4 Protéines), Bmp4 (Montrer BMP4 Protéines) and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.

3. bmp2a is a crucial player in the specification of the ventral pancreatic bud in zebrafish embryos.

4. results indicate that both the induction of a photoreceptor fate and the interaction with Notch (Montrer NOTCH1 Protéines) relies on a canonical BMP/Smad5 (Montrer SMAD5 Protéines) pathway

5. Mypt1 (Montrer PPP1R12A Protéines) mediates coordination between mesoderm and endoderm cell movements in order to carefully position the liver primordium such that it receives a Bmp2 (Montrer BMP4 Protéines) signal that is essential for liver formation