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anti-Human CRTAM Anticorps:
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Human Monoclonal CRTAM Primary Antibody pour CyTOF, FACS - ABIN4899330
Dessarthe, Thedrez, Latouche, Cabillic, Drouet, Daniel, de La Pintière, Catros, Toutirais: CRTAM receptor engagement by Necl-2 on tumor cells triggers cell death of activated Vγ9Vδ2 T cells. dans Journal of immunology (Baltimore, Md. : 1950) 2013
Show all 4 Pubmed References
Human Monoclonal CRTAM Primary Antibody pour FACS - ABIN4895935
Llinàs, Lázaro, de Salort, Matesanz-Isabel, Sintes, Engel: Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry. dans Immunology letters 2010
These results reveal that CRTAM is critical to instruct the differentiation of CD4 (Montrer CD4 Anticorps)(+)CTL through the induction of Eomes (Montrer EOMES Anticorps) and CTL-related gene.
CRTAM is negatively regulated by ZEB1 (Montrer ZEB1 Anticorps) in T cells.
Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1 (Montrer SDK1 Anticorps), CRTAM and RASGRF2 (Montrer RASGRF2 Anticorps) genes.
The cell adhesion molecule (Montrer MCAM Anticorps) Necl-2 (Montrer CADM1 Anticorps) competitively binds the immune receptor CRTAM.
The expression of CRTAM in activated Vgamma9Vdelta2 T cells is quickly downregulated following interaction with Necl-2 (Montrer CADM1 Anticorps) on tumor cells.
Three common variants in the class I MHC-restricted T cell-associated molecule gene were identified that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level.
Results show that CRTAM is a molecule involved in epithelial cell adhesion.
Necl2 (Montrer CADM1 Anticorps)/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system
NK cells and T8 cells recognize Necl-2 (Montrer CADM1 Anticorps) through CRTAM, expressed only on activated cells. CRTAM-Necl-2 (Montrer CADM1 Anticorps) interactions promote cytotoxicity of NK cells and IFN-gamma (Montrer IFNG Anticorps) secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2 (Montrer CADM1 Anticorps)
CRTAM expression is driven by the JNK (Montrer MAPK8 Anticorps)-AP-1 (Montrer FOSB Anticorps) signaling pathway.
During pathogenic infection, Crtam-Cadm1 (Montrer CADM1 Anticorps) interactions regulate the dynamic equilibrium between newly formed CD4 (Montrer CD4 Anticorps)(+) T cells and their retention in the gut (Montrer GUSB Anticorps).
TCS upregulated the expression of tumor suppressor in lung cancer 1 (TSLC1 (Montrer CADM1 Anticorps)) in 3LL tumor cells and the expression of its ligand, class I-restricted T cell-associated molecule (CRTAM), in effector T cells.
In reciprocal crosses involving alcohol-preferring and alcohol-avoiding mouse strains, Crtam is identified as a candidate gene for alcohol preference.
show that CRTAM has an unexpected constitutive expression in adult thymocytes and, remarkably, it is sustained during all stages of thymocyte development.
CRTAM expression is critical for the accumulation of antigen-specific cytotoxic T lymphocytes and their subsequent proliferation within the draining lymph node.
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A\; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008
cytotoxic and regulatory T-cell molecule
, thymocyte activation and development protein
, thymocyte activation and developmental protein
, cytotoxic and regulatory T cell molecule
, class-I MHC-restricted T cell associated molecule
, cytotoxic and regulatory T-cell molecule-like
, class I MHC restricted T cell associated molecule
, class-I MHC-restricted T-cell-associated molecule
, class I-restricted T cell-associated molecule