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Human Monoclonal HAVCR2 Primary Antibody pour FACS - ABIN4896442
Tandon, Giret, Sengupta, York, Wiznia, Rosenberg, Kallas, Ndhlovu, Nixon: Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children. dans PLoS ONE 2012
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Human Polyclonal HAVCR2 Primary Antibody pour CyTOF, FACS - ABIN4899649
Moller-Tank, Albritton, Rennert, Maury: Characterizing functional domains for TIM-mediated enveloped virus entry. dans Journal of virology 2014
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Human Monoclonal HAVCR2 Primary Antibody pour FACS - ABIN4896438
Raziorrouh, Heeg, Kurktschiev, Schraut, Zachoval, Wendtner, Wächtler, Spannagl, Denk, Ulsenheimer, Bengsch, Pircher, Diepolder, Grüner, Jung: Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory molecules. dans PLoS ONE 2014
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Human Monoclonal HAVCR2 Primary Antibody pour CyTOF, FACS - ABIN4899648
Hertoghs, Moerland, van Stijn, Remmerswaal, Yong, van de Berg, van Ham, Baas, ten Berge, van Lier: Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. dans The Journal of clinical investigation 2010
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Human Polyclonal HAVCR2 Primary Antibody pour WB - ABIN1881402
Cao, Zhu, Zhu, Li, Zhang, Xu, Zhang: Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer. dans Cancer immunology, immunotherapy : CII 2010
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Mouse (Murine) Monoclonal HAVCR2 Primary Antibody pour FACS - ABIN4896159
Yadav, Jhunjhunwala, Phung, Lupardus, Tanguay, Bumbaca, Franci, Cheung, Fritsche, Weinschenk, Modrusan, Mellman, Lill, Delamarre: Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. dans Nature 2014
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Mouse (Murine) Monoclonal HAVCR2 Primary Antibody pour FACS - ABIN4896162
Cho, Roche, Sandall, Brass, Seed, Xavier, Medoff: Enhanced Tim3 activity improves survival after influenza infection. dans Journal of immunology (Baltimore, Md. : 1950) 2012
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Human Monoclonal HAVCR2 Primary Antibody pour FACS - ABIN4896439
Lasso, Mateus, Pavía, Rosas, Roa, Thomas, López, González, Puerta, Cuéllar: Inhibitory Receptor Expression on CD8+ T Cells Is Linked to Functional Responses against Trypanosoma cruzi Antigens in Chronic Chagasic Patients. dans Journal of immunology (Baltimore, Md. : 1950) 2015
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Mouse (Murine) Polyclonal HAVCR2 Primary Antibody pour CyTOF, FACS - ABIN4899644
Koh, Chang, Jeon, Yoon, Ahn, Kim, Kim, Jeon, Johnson, Park: The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia. dans Nature communications 2015
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Mouse (Murine) Monoclonal HAVCR2 Primary Antibody pour IHC (fro), FACS - ABIN2476818
Warner: Tobacco industry scientific advisors: serving society or selling cigarettes? dans American journal of public health 1991
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The Tim-3/Gal-9 (Montrer LGALS9 Anticorps) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
TIM-3 polymorphism is associated with response to therapy in hepatitis B virus-related hepatocellular carcinoma.
BMI-1 (Montrer BMI1 Anticorps), TIM-3 and CLL-1 (Montrer COLEC10 Anticorps) have roles in acute myeloid leukemia (Montrer BCL11A Anticorps) prognosis and therapy
Quantification of TIM-3 and KIM-1 (Montrer HAVCR1 Anticorps) mRNA expressions, along with KIM-1 (Montrer HAVCR1 Anticorps) protein measurements in urine and blood could be employed as promising tools for noninvasive diagnosis of allograft dysfunction.
Results show that human acute myeloid leukemia (Montrer BCL11A Anticorps) (AML (Montrer RUNX1 Anticorps)) cells possess a secretory pathway which leads to the production and release of soluble Tim-3 and galectin-9 (Montrer LGALS9 Anticorps). Both proteins prevent the activation of NK cells and impair their AML (Montrer RUNX1 Anticorps) cell-killing activity.
after 14 days of glucocorticoid therapy, clinical findings (serum bilirubin, skin GVHD) and plasma biomarkers (TIM3, ST2, sTNFR1) can predict failure of GVHD treatment and nonrelapse mortality.
These findings suggested that rs10053538 in TIM-3 might increase susceptibility to and promote the progression of breast cancer in Chinese women
Results indicate that T cell Ig and mucin domain 3 protein (TIM-3) polymorphisms (-1516G/T, -574G/T, and +4259T/G) were associated with the increased risk of cancer in Chinese Han population.
In cultured MART1 (Montrer MLANA Anticorps)-specific CD8 (Montrer CD8A Anticorps) T cells stimulated with peptide-loaded artificial antigen-presenting cells, anti-TIM-3 antibody treatment promotes generation of effector T cells, with acquisition of an activated phenotype, increased cytokine production, enhanced proliferation, and a transcription program associated with T cell differentiation. Anti-TIM-3 drives CD8 (Montrer CD8A Anticorps) T cell differentiation through activation of mTORC1.
Our results show that Tim-3 is a critical negative regulator of NLRP3 (Montrer NLRP3 Anticorps) inflammasome and provides a potential target for intervention of diseases with uncontrolled inflammasome activation.
soluble Tim-3 might play inhibitory roles in impaired Tim-3-mediated clearance of apoptotic cells in systemic lupus erythematosus.
CB2R (Montrer CNR2 Anticorps) may have a crucial neuroprotective role following HI insult through the modulation of the inflammatory-related HIF-1alpha (Montrer HIF1A Anticorps)/TIM-3 signalling pathway in microglia
demonstrated that both IL-10 (Montrer IL10 Anticorps) and TGF-beta (Montrer TGFB1 Anticorps) upregulated TIM-3 surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src (Montrer SRC Anticorps) and Bruton's tyrosine kinase (Montrer BTK Anticorps)
Methylation level of the TIM-3 promoter gradually decreased after each round of T-cell polarization, and this decrease was inversely correlated with TIM-3 expression.
in mice, TIM-3 is not essential for development of HDM (Montrer HDAC3 Anticorps)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (Montrer HDAC3 Anticorps)-induced chronic allergic airway inflammation.
Authors found that a CD8 (Montrer CD8A Anticorps)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.
TIM4 (Montrer TIMD4 Anticorps) binds TIM3 on the surface of polarized Th1 (Montrer HAND1 Anticorps) cells to induce Th1 (Montrer HAND1 Anticorps) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.
The Gal-9 (Montrer LGALS9 Anticorps)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (Montrer LYN Anticorps) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (Montrer FCER1A Anticorps) ligation.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog