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Human Polyclonal POLR2A Primary Antibody pour ICC, IF - ABIN4350645
Nordick, Hoffman, Betz, Jaehning: Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II. dans Eukaryotic cell 2008
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Human Monoclonal POLR2A Primary Antibody pour ChIP, CyTOF - ABIN268311
Reid, Svejstrup: DNA damage-induced Def1-RNA polymerase II interaction and Def1 requirement for polymerase ubiquitylation in vitro. dans The Journal of biological chemistry 2004
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Chicken Polyclonal POLR2A Primary Antibody pour DB, WB - ABIN4350647
Hsin, Sheth, Manley: RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing. dans Science (New York, N.Y.) 2011
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Monoclonal POLR2A Primary Antibody pour IF, IP - ABIN534160
Patturajan, Conrad, Bregman, Corden: Yeast carboxyl-terminal domain kinase I positively and negatively regulates RNA polymerase II carboxyl-terminal domain phosphorylation. dans The Journal of biological chemistry 1999
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Polyclonal POLR2A Primary Antibody pour ChIP - ABIN532021
Cramer, Bushnell, Fu, Gnatt, Maier-Davis, Thompson, Burgess, Edwards, David, Kornberg: Architecture of RNA polymerase II and implications for the transcription mechanism. dans Science (New York, N.Y.) 2000
significantly higher binding of POLR2A to the Tmem132d promoter region of high anxiety behavior mice than in low anxiety behavior mice
Skill learning modulates RNA Pol II poising at immediate early genes in the adult striatum. These experiments demonstrate a novel phenomenon of learning induced transcriptional modulation in adult brain.
An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation.
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
These data indicate that, through cooperation with PolII and KDM6A, Spt6 orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation.
site-specific p65 phosphorylation targets NF-kappaB activity to particular gene subsets on a global level by influencing p65 and p-RNAP II promoter recruitment
Data show that that B2 RNA, when present with Pol II in promoter-bound complexes, specifically represses CTD phosphorylation by TFIIH.
investigation of contribution of largest subunit of phosphorylated RNAP II to onset of minor gene activation in zygote; nuclear localization of RNAP II in 1-cell zygote; regulation of RNAP II expression by deposition of acetylated histone on promoter
involvement of RPB1, the largest subunit of RNA polymerase II (RNAP II), in the regulation of transcriptional silencing mechanism
Reduction in RNA Pol II association is indicative of interruption in direct interactions of RNA Pol II with PEPCK promoter, with general transcription factors and/or with coregulator molecules contributeing to activation of PEPCK gene.
These results indicate that Wwp2 plays an important role in regulating expression of Rpb1 in normal physiological conditions.[Rpb1]
Results suggest that RNA polymerase II is selectively required for positive transcriptional regulation of a subset of genes in embryonic stem cells.
The authors that both the ubiquitylation and proteasomal degradation of the largest subunit of pol II (Rpb1) following UV-irradiation are significantly suppressed in Elongin A-deficient cells.
XPC is an RNA polymerase II cofactor recruiting ATAC coactivator complex to promoters by interacting with E2F1.
weak, multivalent interactions between TAF15 fibrils and heptads throughout RNA pol II CTD collectively mediate complex formation.
This shows that CDK9 stimulates release of paused polymerase and activates transcription by increasing the number of transcribing polymerases and thus the amount of mRNA synthesized per time.
Results identified rs2071504 in POLR2A gene to be associated with poor overall and disease-free survival of patients with an early-stage non-small cell lung cancer.
Dara indicate that hydrogen peroxide alters RNA polymerase II (Pol II) occupancy at promoters and enhancers genome-wide.
Rpb1/2 dynamics help govern the decision between sense and divergent antisense transcription.
The results showed heterogeneity in the responses of individual KSHV episomes to stimuli within a single reactivating cell; those episomes that did respond to stimulation, aggregated within large domains that appear to function as viral transcription factories. A significant portion of cellular RNA polymerase II was trapped in these factories and served to transcribe viral genomes.
The authors show here that glutamine deprivation suppresses translation of endogenous MYC via coupling the 3'-UTR of the MYC mRNA and RNA polymerase II function.
Data show that inhibition of VCP/p97, or siRNA-mediated ablation of VCP/p97 impairs ultraviolet radiation (UVR)-induced RNA polymerase II (RNAPII) degradation.
Role of chromatin-bound EGFR and ERK kinases in RNA polymerase 2 transcription
recurrent somatic mutations in POLR2A hijack this essential enzyme and drive meningioma neoplasia
the Elongin A ubiquitin ligase and the CSB protein function together in a common pathway in response to Pol II stalling and DNA damage
By studying global gene expression patterns and genome-wide DNA-binding patterns of CGGBP1, it has been shown that a possible mechanism through which it affects the expression of RNA Pol II-transcribed genes in trans depends on Alu RNA.
Using a 7,781-sample pan-cancer dataset, we first confirmed this in POLR2A are known to confer elevated sensitivity to pharmacological suppression.hese include the POLR2A interacting protein INTS10 as well as genes involved in mRNA splicing, nonsense-mediated mRNA
HIV Tat precisely controls RNA polymerase II recruitment and pause release to fine-tune the initiation and elongation steps in target genes.
TOP1 bound at promoters was discovered to become fully active only after pause-release. This transition coupled the phosphorylation of the carboxyl-terminal-domain (CTD) of RNA polymerase II (RNAPII) with stimulation of TOP1 above its basal rate, enhancing its processivity.
Its variant is not related to sporadic PD in Chinese Han population.
Data suggest RNA polymerase II (POLR2A) is extensively modified on its unique C-terminal domain (CTD) by O-GlcNAc transferase (OGT); efficient O-GlcNAcylation requires a minimum of 20 heptad CTD repeats in POLR2A and more than half of NTD of OGT.
Serine phosphorylation stimulates whereas tyrosine phosphorylation inhibits the protein-binding activity of the RNA Pol II C-terminal domain.
The amount of RNA polymerase II (RNAPII) on the HIV promoter and other viral regions was strongly diminished in HIV-infected CD4+ cells co-cultivated with cell non-cytotoxic antiviral response-expressing CD8+ cells.
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
DNA-directed RNA polymerase II subunit RPB1
, polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
, 220 kDa DNA-directed RNA polymerase polypeptide A
, DNA-directed RNA polymerase II largest subunit
, RNA polymerase II polypeptide A
, DNA-directed RNA polymerase II A
, DNA-directed RNA polymerase II subunit A
, DNA-directed RNA polymerase III largest subunit
, RNA polymerase II 1
, RNA polymerase II subunit B1
, Polymerase (RNA II (DNA directed), large polypeptide
, DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit
, RNA-directed RNA polymerase II subunit RPB1
, polymerase (RNA) II (DNA directed) polypeptide A (220kD)