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anti-Mouse (Murine) POLR2A Anticorps:
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Human Polyclonal POLR2A Primary Antibody pour ICC, IF - ABIN4350645
Nordick, Hoffman, Betz, Jaehning: Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II. dans Eukaryotic cell 2008
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Human Monoclonal POLR2A Primary Antibody pour ChIP, CyTOF - ABIN268311
Reid, Svejstrup: DNA damage-induced Def1-RNA polymerase II interaction and Def1 requirement for polymerase ubiquitylation in vitro. dans The Journal of biological chemistry 2004
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Chicken Polyclonal POLR2A Primary Antibody pour DB, WB - ABIN4350647
Hsin, Sheth, Manley: RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing. dans Science (New York, N.Y.) 2011
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Skill learning modulates RNA Pol II (Montrer POLR2F Anticorps) poising at immediate early (Montrer JUN Anticorps) genes in the adult striatum. These experiments demonstrate a novel phenomenon of learning induced transcriptional modulation in adult brain.
An H3K9/S10 (Montrer PSMD6 Anticorps) methyl-phospho switch modulates Polycomb (Montrer CBX2 Anticorps) and Pol II (Montrer 0 Anticorps) binding at repressed genes during differentiation.
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
These data indicate that, through cooperation with PolII (Montrer 0 Anticorps) and KDM6A (Montrer KDM6A Anticorps), Spt6 (Montrer SUPT6H Anticorps) orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation.
site-specific p65 (Montrer NFkBP65 Anticorps) phosphorylation targets NF-kappaB (Montrer NFKB1 Anticorps) activity to particular gene subsets on a global level by influencing p65 (Montrer NFkBP65 Anticorps) and p-RNAP II (Montrer 0 Anticorps) promoter recruitment
Data show that that B2 RNA, when present with Pol II (Montrer 0 Anticorps) in promoter-bound complexes, specifically represses CTD phosphorylation by TFIIH (Montrer GTF2H4 Anticorps).
investigation of contribution of largest subunit of phosphorylated RNAP II (Montrer 0 Anticorps) to onset of minor gene activation in zygote; nuclear localization of RNAP II (Montrer 0 Anticorps) in 1-cell zygote; regulation of RNAP II (Montrer 0 Anticorps) expression by deposition of acetylated histone on promoter
involvement of RPB1, the largest subunit of RNA polymerase II (RNAP II (Montrer 0 Anticorps)), in the regulation of transcriptional silencing mechanism
Reduction in RNA Pol II (Montrer POLR2F Anticorps) association is indicative of interruption in direct interactions of RNA Pol II (Montrer POLR2F Anticorps) with PEPCK (Montrer PEPCK Anticorps) promoter, with general transcription factors and/or with coregulator molecules contributeing to activation of PEPCK (Montrer PEPCK Anticorps) gene.
These results indicate that Wwp2 plays an important role in regulating expression of Rpb1 in normal physiological conditions.[Rpb1]
weak, multivalent interactions between TAF15 fibrils and heptads throughout RNA pol II CTD collectively mediate complex formation.
This shows that CDK9 stimulates release of paused polymerase and activates transcription by increasing the number of transcribing polymerases and thus the amount of mRNA synthesized per time.
Results identified rs2071504 in POLR2A gene to be associated with poor overall and disease-free survival of patients with an early-stage non-small cell lung cancer.
Dara indicate that hydrogen peroxide alters RNA polymerase II (Pol II (Montrer 0 Anticorps)) occupancy at promoters and enhancers genome-wide.
Rpb1/2 dynamics help govern the decision between sense and divergent antisense transcription.
The results showed heterogeneity in the responses of individual KSHV episomes to stimuli within a single reactivating cell; those episomes that did respond to stimulation, aggregated within large domains that appear to function as viral transcription factories. A significant portion of cellular RNA polymerase II was trapped in these factories and served to transcribe viral genomes.
The authors show here that glutamine deprivation suppresses translation of endogenous MYC via coupling the 3'-UTR of the MYC mRNA and RNA polymerase II function.
Data show that inhibition of VCP/p97 (Montrer vcp Anticorps), or siRNA-mediated ablation of VCP/p97 (Montrer vcp Anticorps) impairs ultraviolet radiation (UVR)-induced RNA polymerase II (RNAPII (Montrer 0 Anticorps)) degradation.
Role of chromatin-bound EGFR and ERK kinases in RNA polymerase 2 transcription
recurrent somatic mutations in POLR2A hijack this essential enzyme and drive meningioma neoplasia
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
DNA-directed RNA polymerase II subunit RPB1
, polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
, 220 kDa DNA-directed RNA polymerase polypeptide A
, DNA-directed RNA polymerase II largest subunit
, RNA polymerase II polypeptide A
, DNA-directed RNA polymerase II A
, DNA-directed RNA polymerase II subunit A
, DNA-directed RNA polymerase III largest subunit
, RNA polymerase II 1
, RNA polymerase II subunit B1
, Polymerase (RNA II (DNA directed), large polypeptide
, DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit
, RNA-directed RNA polymerase II subunit RPB1
, polymerase (RNA) II (DNA directed) polypeptide A (220kD)