anti-Humain HSPB1 anticorps pour Enzyme Immunoassay

Recommended HSPB1 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Heat Shock 27kDa Protein 1 (HSPB1) Anticorps
  • CMT2F
  • HMN2B
  • HS.76067
  • HSP27
  • HSP28
  • Hsp25
  • SRP27
  • 27kDa
  • Hsp27
  • cb153
  • cb660
  • hsp1
  • hsp25
  • hsp27
  • id:ibd2821
  • sb:cb660
  • zgc:103437
  • HSPB1
  • cmt2f
  • hs.76067
  • hsp28
  • heat shock protein family B (small) member 1
  • heat shock protein 1
  • heat shock protein, alpha-crystallin-related, 1
  • heat shock protein family B (small) member 1 L homeolog
  • HSPB1
  • Hspb1
  • hspb1
  • hspb1.L
Épitope
pSer78
84
72
55
45
22
16
13
13
10
10
10
10
6
6
5
5
5
5
5
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
825
277
272
96
85
71
68
66
36
30
29
26
18
11
11
9
6
3
2
2
2
2
1
1
1
Hôte
Lapin
502
341
2
Clonalité
Polyclonal
Conjugué
Cet anticorp HSPB1 est non-conjugé
34
33
23
22
19
13
13
13
11
11
10
10
10
10
10
9
9
9
5
5
5
5
5
5
5
5
5
4
4
3
3
3
3
3
3
3
3
3
3
3
2
Application
Enzyme Immunoassay (EIA)
715
327
270
266
228
212
169
157
59
40
17
13
11
8
6
4
2
2
1
1
1
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N° du produit ABIN358314
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN453119 EIA WB Rabbit Middle Region Connectez-vous pour afficher Polyclonal 5
1 ABIN317528 EIA IHC (p) WB Mouse IgG1 AA 1-205, N-Term Connectez-vous pour afficher 2A5 3
1 ABIN5610928 EIA WB Rabbit Ig Fraction Ser83 Connectez-vous pour afficher Polyclonal
1 ABIN5610927 EIA IHC (p) WB Rabbit Ig Fraction Ser82 Connectez-vous pour afficher Polyclonal
1 ABIN5610926 EIA IHC (p) WB Rabbit Ig Fraction Ser78 Connectez-vous pour afficher Polyclonal
1 ABIN265470 EIA IHC (p) WB Rabbit Connectez-vous pour afficher Polyclonal
1 ABIN1107614 EIA IF IHC (p) WB Mouse IgG1 Connectez-vous pour afficher 5D7 2
1 ABIN5611604 EIA IHC (p) WB Rabbit IgG Connectez-vous pour afficher Polyclonal
1 ABIN400642 EIA IF IHC (p) IP WB Mouse IgG1 Connectez-vous pour afficher n-a
1 ABIN5550950 EIA IHC (p) IP WB Mouse IgG2b Connectez-vous pour afficher 5D12-A12
1 ABIN5550951 EIA IHC (p) IP WB Mouse IgG2b Connectez-vous pour afficher 5D12-A12
1 ABIN613191 EIA RIA Biotin Rabbit IgG Connectez-vous pour afficher Polyclonal
1 ABIN613665 EIA RIA Rabbit IgG Connectez-vous pour afficher Polyclonal

General

Antigène Heat Shock 27kDa Protein 1 (HSPB1) Anticorps
Épitope pSer78
(84), (72), (55), (45), (22), (16), (13), (13), (10), (10), (10), (10), (6), (6), (5), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Humain
(825), (277), (272), (96), (85), (71), (68), (66), (36), (30), (29), (26), (18), (11), (11), (9), (6), (3), (2), (2), (2), (2), (1), (1), (1)
Hôte Lapin
(502), (341), (2)
Clonalité
Polyclonal
Conjugué Cet anticorp HSPB1 est non-conjugé
(34), (33), (23), (22), (19), (13), (13), (13), (11), (11), (10), (10), (10), (10), (10), (9), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2)
Application Enzyme Immunoassay (EIA)
(715), (327), (270), (266), (228), (212), (169), (157), (59), (40), (17), (13), (11), (8), (6), (4), (2), (2), (1), (1), (1)
Pubmed 5 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-HSPB1 anticorps

Détail du antigène HSPB1 Information d'application Stockage References for anti-HSPB1 antibody (ABIN358314) Images
Specificité This antibody detects HSPB1 pSer78.
Purification Protein A Chromatography followed by two-step phosphospecific peptide affinity purification.
Immunogène This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Ser78 of human HSBP1.
Isotype Ig Fraction

Détail du antigène HSPB1

Détail du produit anti-HSPB1 anticorps Information d'application Stockage References for anti-HSPB1 antibody (ABIN358314) Images Haut de la page
Antigène
Autre désignation HSPB1 / HSP27 (HSPB1 Antibody Extrait)
Sujet In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSBP1 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoters (e.g. phorbol esters) and calcium ionophores, and high levels are associated with carcinoma of the breast and with endometrial adenocarcinomas. Heat shock of HeLa cell cultures, or treatment with arsenite, phorbol ester, or tumor necrosis factor, causes a rapid phosphorylation of preexisting HSBP1, with Ser82 as the major site and Ser78 the minor site of phosphorylation. HSBP1 may exert phosphorylation-activated functions linked with growth signaling pathways in unstressed cells. A homeostatic function at this level could protect cells from adverse effects of signal transduction systems which may be activated inappropriately during stress.Synonyms: 28 kDa heat shock protein, Estrogen-regulated 24 kDa protein, HSP25, HSP28, Heat shock 27 kDa protein, Heat shock protein beta-1, SRP27, Stress-responsive protein 27
Poids moléculaire 22783 Da
ID gène 3315, 9606
UniProt P04792
Pathways Signalisation MAPK, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, VEGF Signaling

Information d'application

Détail du produit anti-HSPB1 anticorps Détail du antigène HSPB1 Stockage References for anti-HSPB1 antibody (ABIN358314) Images Haut de la page
Indications d'application ELISA: 1/1,000. Dot Blot: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Stockage

Détail du produit anti-HSPB1 anticorps Détail du antigène HSPB1 Information d'application References for anti-HSPB1 antibody (ABIN358314) Images Haut de la page
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-HSPB1 antibody (ABIN358314)

Détail du produit anti-HSPB1 anticorps Détail du antigène HSPB1 Information d'application Stockage Images Haut de la page
Background publications

Wano, Kita, Takahashi, Sugaya, Hino, Hosoya, Suzuki: "Protective role of HSP27 against UVC-induced cell death in human cells." dans: Experimental cell research, Vol. 298, Issue 2, pp. 584-92, 2004

Evgrafov, Mersiyanova, Irobi, Van Den Bosch, Dierick, Leung, Schagina, Verpoorten, Van Impe, Fedotov, Dadali, Auer-Grumbach, Windpassinger, Wagner, Mitrovic, Hilton-Jones, Talbot, Martin, Vasserman et al.: "Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. ..." dans: Nature genetics, Vol. 36, Issue 6, pp. 602-6, 2004

Song, Ethier, Dziubinski, Lin: "Stat3 modulates heat shock 27kDa protein expression in breast epithelial cells." dans: Biochemical and biophysical research communications, Vol. 314, Issue 1, pp. 143-50, 2004

Chauhan, Li, Hideshima, Podar, Mitsiades, Mitsiades, Catley, Tai, Hayashi, Shringarpure, Burger, Munshi, Ohtake, Saxena, Anderson: "Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance." dans: Blood, Vol. 102, Issue 9, pp. 3379-86, 2003

Van Why, Mann, Ardito, Thulin, Ferris, Macleod, Kashgarian, Siegel: "Hsp27 associates with actin and limits injury in energy depleted renal epithelia." dans: Journal of the American Society of Nephrology : JASN, Vol. 14, Issue 1, pp. 98-106, 2002

Images

Détail du produit anti-HSPB1 anticorps Détail du antigène HSPB1 Information d'application Stockage References for anti-HSPB1 antibody (ABIN358314) Haut de la page
Supplier Images
 image for anti-Heat Shock 27kDa Protein 1 (HSPB1) (pSer78) antibody (ABIN358314) anti-Heat Shock 27kDa Protein 1 (HSPB1) (pSer78) antibody