Profil protéine

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells\; MAPKKK5 does not activate MAPK/ERK.

Alternative names and synonyms associated with MAP3K5

• mitogen-activated protein kinase kinase kinase 5 (MAP3K5) anticorps
• mitogen-activated protein kinase kinase kinase 5 (MAPKKK5) anticorps
• mitogen-activated protein kinase kinase kinase 5 (Map3k5) anticorps
• mitogen-activated protein kinase kinase kinase 5 (map3k5) anticorps

• 7420452D20Rik anticorps
• ASK anticorps
• Ask1 anticorps
• MAPKKK5 anticorps
• Mekk5 anticorps
• Afficher tous les alias de synonymes
• mitogen-activated protein kinase kinase kinase 5 anticorps
• MUD21.11 anticorps
• MUD21_11 anticorps
• RGD1306565 anticorps

Protein level used designations for MAP3K5

ASK-1 , MAP/ERK kinase kinase 5 , MAPK/ERK kinase kinase 5 , MEK kinase 5 , MEKK 5 , apoptosis signal regulating kinase 1 , apoptosis signal-regulating kinase 1 , mitogen activated protein kinase kinase kinase 5 , mitogen-activated protein kinase kinase kinase 5 , mitogen-activated protein kinase kinase kinase 5 pseudogene