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anti-Human IKBKB Anticorps:
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Human Monoclonal IKBKB Primary Antibody pour CyTOF, FACS - ABIN252473
Verma, Stevenson, Schwarz, Van Antwerp, Miyamoto: Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. dans Genes & development 1995
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Human Monoclonal IKBKB Primary Antibody pour IP, WB - ABIN967355
DiDonato, Hayakawa, Rothwarf, Zandi, Karin: A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. dans Nature 1997
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Human Monoclonal IKBKB Primary Antibody pour FACS, GS - ABIN252477
Vacca, Felli, Palermo, Di Mario, Calce, Di Giovine, Frati, Gulino, Screpanti: Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. dans The EMBO journal 2006
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Human Polyclonal IKBKB Primary Antibody pour IF, IHC (p) - ABIN1882097
Tang, Inohara, Wang, Nuñez, Guan: Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. dans The Journal of biological chemistry 2003
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Human Monoclonal IKBKB Primary Antibody pour WB - ABIN1882049
Edwards: Anticipation of disaster. dans Journal of the Royal Society of Medicine 1991
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Human Monoclonal IKBKB Primary Antibody pour WB - ABIN387826
Niida, Tanaka, Kamitani: Downregulation of active IKK beta by Ro52-mediated autophagy. dans Molecular immunology 2010
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Human Polyclonal IKBKB Primary Antibody pour DB - ABIN1881450
Yatherajam, Banerjee, McCorkell, Solt, Hanson, Madge, Kang, Worley, Orange, May: Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3. dans Journal of immunology (Baltimore, Md. : 1950) 2010
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Human Polyclonal IKBKB Primary Antibody pour DB - ABIN1881453
Kenneth, Mudie, Rocha: IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function. dans The EMBO journal 2010
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Human Polyclonal IKBKB Primary Antibody pour DB - ABIN1881451
Zhao, Li, Chen: CC2D1A, a DM14 and C2 domain protein, activates NF-kappaB through the canonical pathway. dans The Journal of biological chemistry 2010
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Human Polyclonal IKBKB Primary Antibody pour DB - ABIN1881449
Schuurhof, Bont, Siezen, Hodemaekers, van Houwelingen, Kimman, Hoebee, Kimpen, Janssen: Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. dans Pediatric pulmonology 2010
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crystal structure of IKKbeta in complex with an inhibitor, at a resolution of 3.6 A
Expression of TAp63, IKKbeta and XBP1s is also increased in livers of obese patients with liver steatosis.
IKK2 and NF-kappaB (Montrer NFKB1 Anticorps) are related to poor prognosis and are potential predictors of response to platinum-based chemotherapy in high grade serous carcinoma
These studies identify functional EREs in the IKKB promoter and identify IKKB as an ERalpha (Montrer ESR1 Anticorps) and NSC35446.HCl-regulated gene, and they suggest that NF-kappaB (Montrer NFKB1 Anticorps) and IKKB, which were previously linked to antiestrogen resistance, are targets for NSC35446.HCl in reversing antiestrogen resistance.
Curcumin suppressed CXCL5 (Montrer CXCL5 Anticorps) expression by direct inhibition of IKKbeta phosphorylation, and inhibition of p38 MAPK (Montrer MAPK14 Anticorps) via induction of negative regulator MKP-1 (Montrer DUSP1 Anticorps).
This study demonstrated that nerve injury-induced Csf1 (Montrer CSF1 Anticorps) upregulation was ameliorated indicating that IKK (Montrer CHUK Anticorps)/NF-kappaBeta (Montrer NFKB1 Anticorps)-dependent SGC (Montrer SGCB Anticorps) activation induced Csf1 (Montrer CSF1 Anticorps) expression in sensory neurons.
Findings uncover a novel function for IKKbeta/mHTTx1 interactions in regulating IL-34 (Montrer IL34 Anticorps) production, and implicate a role for IL-34 (Montrer IL34 Anticorps) in non-cell-autonomous, microglial-dependent neurodegeneration in HD.
HOTAIR operates the action of IKKalpha (Montrer CHUK Anticorps), IKKbeta, IKKgamma (Montrer IKBKG Anticorps) in liver cancer stem cells
These results suggested that APN (Montrer ANPEP Anticorps) ameliorated endothelial inflammation and IR through ROS (Montrer ROS1 Anticorps)/IKKbeta pathway.
p300 (Montrer EP300 Anticorps)-dependent histone H3 (Montrer HIST3H3 Anticorps) acetylation and C/EBPbeta (Montrer CEBPB Anticorps)-regulated IKKbeta expression contribute to thrombin (Montrer F2 Anticorps)-induced IL-8/CXCL8 (Montrer IL8 Anticorps) expression in human lung epithelial cells.
EGFR (Montrer EGFR Anticorps)/PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps)/mTOR (Montrer FRAP1 Anticorps)/IKK-beta/NF-kappaB (Montrer NFKB1 Anticorps) signaling promotes head and neck cancer progression.
Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin (Montrer PRL Anticorps) in bovine mammary epithelial cells.
Elevated levels of common free fatty acids found in human serum activate IKKbeta in bovine endothelial cells leading to reduced nitric oxide, and may serve to link pathways involved in inflammation and endothelial dysfunction.
High glucose treatment also activated IKKbeta, and pretreatment with aspirin, a pharmacological inhibitor of IKKbeta, prevented both glucose-induced IKKbeta activation and the effect of high glucose to impair insulin (Montrer INS Anticorps)-mediated NO production.
High glucose-induced IKK (Montrer CHUK Anticorps)-Hsp-90 (Montrer HSP90 Anticorps) interaction contributes to endothelial dysfunction.
Hepatic overexpression of N-terminal transactivation domain TAp63 induces liver steatosis through IKKbeta activation and the induction of ER stress.
Astrocyte IKKbeta deletion following high-fat diet-but not before- reduced glucose intolerance and insulin (Montrer INS Anticorps) resistance. Hypothalamic inflammation and astrocytosis were reduced in HFD-fed IKKbeta-AKO mice.
IKKbeta is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets.
NF-kappaB (Montrer NFKB1 Anticorps) is the transcription factor in regulating many proinflammatory cytokine genes.
p55TNFR-IKK2-Ripk3 (Montrer RIPK3 Anticorps) signalling orchestrates arthritogenic and death responses in synovial fibroblasts
Pulmonary inflammation due to lung-specific overexpression of IKK2ca was sufficient to increase circulating TNFalpha (Montrer TNF Anticorps) and IL-6 (Montrer IL6 Anticorps) levels, adipose expression of Tnfalpha (Montrer TNF Anticorps) and Il-6 (Montrer IL6 Anticorps) mRNA, aortic endothelial dysfunction, and systemic insulin (Montrer INS Anticorps) resistance.
prolonged IKKbeta inhibition decimates circulating Tregs and improves Cytotoxic t lymphocytes responses when commenced after tumor vaccination, indicating that IKKbeta represents a druggable checkpoint.
Results reveal that IKKbeta activity prevents skin tumor development, and shed light on the complex nature of IKKbeta effects on cancer progression, as IKKbeta can both promote and prevent carcinogenesis depending on the cell type or molecular context.
IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration
Chronic overnutrition and astrocytic IKKbeta/NF-kappaB (Montrer NFKB1 Anticorps) upregulation similarly impaired astrocytic plasticity, leading to sustained shortening of high-order processes. In physiology, astrocytic IKKbeta/NF-kappaB (Montrer NFKB1 Anticorps) upregulation resulted in early-onset effects, including glucose intolerance and blood pressure rise, and late-onset effects, including body weight and fat gain.
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
, inhibitor of nuclear factor kappa-B kinase subunit beta
, inhibitor of nuclear factor kappa-B kinase subunit beta-like
, IKK-like protein
, LPS-responsive kinase
, cactus kinase
, deficient 5
, immune response
, lipopolysaccharide activated kinase
, mmune response deficient 5
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, nuclear factor NF-kappa-B inhibitor kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of kappa light chain gene enhancer in B cells, kinase beta