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Human Monoclonal IKBKB Primary Antibody pour CyTOF, FACS - ABIN252473
Verma, Stevenson, Schwarz, Van Antwerp, Miyamoto: Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. dans Genes & development 1995
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Human Monoclonal IKBKB Primary Antibody pour FACS - ABIN4324267
Manna, Mukhopadhyay, Aggarwal: Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. dans Journal of immunology (Baltimore, Md. : 1950) 2000
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Human Monoclonal IKBKB Primary Antibody pour IP, WB - ABIN967355
DiDonato, Hayakawa, Rothwarf, Zandi, Karin: A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. dans Nature 1997
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Human Monoclonal IKBKB Primary Antibody pour FACS, GS - ABIN252477
Vacca, Felli, Palermo, Di Mario, Calce, Di Giovine, Frati, Gulino, Screpanti: Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. dans The EMBO journal 2006
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Human Polyclonal IKBKB Primary Antibody pour IF, IHC (p) - ABIN1882097
Tang, Inohara, Wang, Nuñez, Guan: Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. dans The Journal of biological chemistry 2003
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Human Monoclonal IKBKB Primary Antibody pour WB - ABIN1882049
Edwards: Anticipation of disaster. dans Journal of the Royal Society of Medicine 1991
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Human Monoclonal IKBKB Primary Antibody pour WB - ABIN387826
Niida, Tanaka, Kamitani: Downregulation of active IKK beta by Ro52-mediated autophagy. dans Molecular immunology 2010
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Human Polyclonal IKBKB Primary Antibody pour IHC - ABIN966373
Mercurio, Zhu, Murray, Shevchenko, Bennett, Li, Young, Barbosa, Mann, Manning, Rao: IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. dans Science (New York, N.Y.) 1997
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Human Polyclonal IKBKB Primary Antibody pour IHC - ABIN966375
Hu, Wang: IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. dans Gene 1999
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Human Polyclonal IKBKB Primary Antibody pour IHC - ABIN966374
Shindo, Nakano, Sakon, Yagita, Mihara, Okumura: Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization. dans Cytogenetics and cell genetics 1998
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crystal structure of IKKbeta in complex with an inhibitor, at a resolution of 3.6 A
Curcumin suppressed CXCL5 (Montrer CXCL5 Anticorps) expression by direct inhibition of IKKbeta phosphorylation, and inhibition of p38 MAPK (Montrer MAPK14 Anticorps) via induction of negative regulator MKP-1 (Montrer DUSP1 Anticorps).
This study demonstrated that nerve injury-induced Csf1 (Montrer CSF1 Anticorps) upregulation was ameliorated indicating that IKK (Montrer CHUK Anticorps)/NF-kappaBeta (Montrer NFKB1 Anticorps)-dependent SGC (Montrer SGCB Anticorps) activation induced Csf1 (Montrer CSF1 Anticorps) expression in sensory neurons.
Findings uncover a novel function for IKKbeta/mHTTx1 interactions in regulating IL-34 (Montrer IL34 Anticorps) production, and implicate a role for IL-34 (Montrer IL34 Anticorps) in non-cell-autonomous, microglial-dependent neurodegeneration in HD.
HOTAIR operates the action of IKKalpha (Montrer CHUK Anticorps), IKKbeta, IKKgamma (Montrer IKBKG Anticorps) in liver cancer stem cells
These results suggested that APN (Montrer ANPEP Anticorps) ameliorated endothelial inflammation and IR through ROS (Montrer ROS1 Anticorps)/IKKbeta pathway.
p300 (Montrer EP300 Anticorps)-dependent histone H3 (Montrer HIST3H3 Anticorps) acetylation and C/EBPbeta (Montrer CEBPB Anticorps)-regulated IKKbeta expression contribute to thrombin (Montrer F2 Anticorps)-induced IL-8/CXCL8 (Montrer IL8 Anticorps) expression in human lung epithelial cells.
EGFR (Montrer EGFR Anticorps)/PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps)/mTOR (Montrer FRAP1 Anticorps)/IKK-beta/NF-kappaB (Montrer NFKB1 Anticorps) signaling promotes head and neck cancer progression.
our results illustrate a new direction in nitrosourea treatment, and reveal that the combination of ROS (Montrer ROS1 Anticorps)-inducing IKKbeta inhibitors with nitrosoureas can be potentially exploited for melanoma therapy
Smad7 (Montrer SMAD7 Anticorps) expression in necrotizing enterocolitis macrophages interrupts TGF-beta (Montrer TGFB1 Anticorps) signaling and promotes NF-kappaB (Montrer NFKB1 Anticorps)-mediated inflammatory signaling in these cells through increased expression of IKK-beta
High IKBKB expression is associated with prostate cancer.
Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin (Montrer PRL Anticorps) in bovine mammary epithelial cells.
Elevated levels of common free fatty acids found in human serum activate IKKbeta in bovine endothelial cells leading to reduced nitric oxide, and may serve to link pathways involved in inflammation and endothelial dysfunction.
High glucose treatment also activated IKKbeta, and pretreatment with aspirin, a pharmacological inhibitor of IKKbeta, prevented both glucose-induced IKKbeta activation and the effect of high glucose to impair insulin (Montrer INS Anticorps)-mediated NO production.
High glucose-induced IKK (Montrer CHUK Anticorps)-Hsp-90 (Montrer HSP90 Anticorps) interaction contributes to endothelial dysfunction.
Pulmonary inflammation due to lung-specific overexpression of IKK2ca was sufficient to increase circulating TNFalpha (Montrer TNF Anticorps) and IL-6 (Montrer IL6 Anticorps) levels, adipose expression of Tnfalpha (Montrer TNF Anticorps) and Il-6 (Montrer IL6 Anticorps) mRNA, aortic endothelial dysfunction, and systemic insulin (Montrer INS Anticorps) resistance.
prolonged IKKbeta inhibition decimates circulating Tregs and improves Cytotoxic t lymphocytes responses when commenced after tumor vaccination, indicating that IKKbeta represents a druggable checkpoint.
Results reveal that IKKbeta activity prevents skin tumor development, and shed light on the complex nature of IKKbeta effects on cancer progression, as IKKbeta can both promote and prevent carcinogenesis depending on the cell type or molecular context.
IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration
Chronic overnutrition and astrocytic IKKbeta/NF-kappaB (Montrer NFKB1 Anticorps) upregulation similarly impaired astrocytic plasticity, leading to sustained shortening of high-order processes. In physiology, astrocytic IKKbeta/NF-kappaB (Montrer NFKB1 Anticorps) upregulation resulted in early-onset effects, including glucose intolerance and blood pressure rise, and late-onset effects, including body weight and fat gain.
Expression of both wild-type and catalytically-inactive Y7F mutant GSTP (Montrer GSTP1 Anticorps) significantly attenuated LPS (Montrer TLR4 Anticorps)- or IKKbeta-induced production of GM-CSF (Montrer CSF2 Anticorps). These studies indicate a complex role for GSTP (Montrer GSTP1 Anticorps) in modulating NF-kappaB (Montrer NFKB1 Anticorps), which may involve S-glutathionylation of IKK (Montrer CHUK Anticorps) proteins, and interaction with NF-kappaB (Montrer NFKB1 Anticorps) family members.
Myeloid ikkbeta gene deletion significantly reduced the percentage of CD4 (Montrer CD4 Anticorps)(+)/IFN-gamma (Montrer IFNG Anticorps)(+) (Th1 (Montrer HAND1 Anticorps)) and CD4 (Montrer CD4 Anticorps)(+)/IL-17 (Montrer IL17A Anticorps)(+) (Th17) cells
Pharmacological and genetic inhibition of IKKbeta decreased voluntary ethanol consumption, providing initial support for IKKbeta as a potential therapeutic target for alcohol abuse.
Myeloid IKKbeta deficiency prevents Western diet-induced obesity and visceral adiposity in females but not in males, and attenuates hyperglycemia, global insulin (Montrer INS Anticorps) resistance, and non-alcoholic steatohepatitis in both genders. In contrast, all metabolic sequela including non-alcoholic steatohepatitis are aggravated by hepatocyte IKKbeta deficiency (IkbkbDeltahep) in male but not female mice.
lymphocyte-specific deletion of IKK2 or NEMO (Montrer IKBKG Anticorps) aggravated kidney injury after ischemia-reperfusion injury, and, in both conditions, the percentage of Th17 cells was increased.
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
, inhibitor of nuclear factor kappa-B kinase subunit beta
, inhibitor of nuclear factor kappa-B kinase subunit beta-like
, IKK-like protein
, LPS-responsive kinase
, cactus kinase
, deficient 5
, immune response
, lipopolysaccharide activated kinase
, mmune response deficient 5
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, nuclear factor NF-kappa-B inhibitor kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of kappa light chain gene enhancer in B cells, kinase beta