IKBKB anticorps (AA 395-588)

N° du produit ABIN7156261

Détail du produit anti-IKBKB anticorps

Antigène: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Épitope: AA 395-588

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IKBKB est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Inhibitor of nuclear factor kappa-B kinase subunit beta protein (395-588AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IKBKB

Antigène: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Autre désignation: IKBKB (IKBKB Produits)

Synonymes: anticorps ikk-beta, anticorps ikk2, anticorps ikkb, anticorps ikkbeta, anticorps IKBKB, anticorps IKKB, anticorps CG4201, anticorps DIK, anticorps DLAK, anticorps DmIKK, anticorps DmIKKBeta, anticorps DmIKKb, anticorps DmIKKbeta, anticorps DmIkkbeta, anticorps Dmel\\CG4201, anticorps Dmikkb, anticorps Dmikkbeta, anticorps IK, anticorps IKK, anticorps IKK-beta, anticorps IKKb, anticorps IKKbeta, anticorps IRD-5, anticorps IRD5, anticorps Ik, anticorps Ikkb, anticorps Ikkbeta, anticorps Ird-5, anticorps Ird5, anticorps LRK, anticorps Lak, anticorps anon-89Bd, anticorps dIKK, anticorps dIKK-beta, anticorps dIKKbeta, anticorps dLak, anticorps dmIKKbeta, anticorps ikk, anticorps ird, anticorps ird5/DmIkk[beta], anticorps IKK2, anticorps NFKBIKB, anticorps AIM-1, anticorps AI132552, anticorps IKK-2, anticorps IKK[b], anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog, anticorps inhibitor of nuclear factor kappa B kinase subunit beta, anticorps I-kappaB kinase beta, anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, anticorps inhibitor of kappaB kinase beta, anticorps ikbkb.L, anticorps IKBKB, anticorps ikbkb, anticorps IKKbeta, anticorps Ikbkb

Sujet:

Background: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

Aliases: I kappa B kinase 2 antibody, I kappa B kinase beta antibody, I-kappa-B kinase 2 antibody, I-kappa-B-kinase beta antibody, IkBKB antibody, IKK beta antibody, IKK-B antibody, IKK-beta antibody, IKK2 antibody, IKKB antibody, IKKB_HUMAN antibody, IMD15 antibody, Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta antibody, Inhibitor of nuclear factor kappa-B kinase subunit beta antibody, NFKBIKB antibody, Nuclear factor NF-kappa-B inhibitor kinase beta antibody

UniProt: O14920

Pathways: Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins