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anti-Human MAP3K14 Anticorps:
anti-Rat (Rattus) MAP3K14 Anticorps:
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Human Polyclonal MAP3K14 Primary Antibody pour WB - ABIN392539
Bouzakri, Zierath: MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. dans The Journal of biological chemistry 2007
Show all 4 Pubmed References
results suggest that changes in the relative concentrations of RelB (Montrer RELB Anticorps), NIK:IKK1, and p100 (Montrer CUX1 Anticorps) during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100 (Montrer CUX1 Anticorps).
report a detailed state-of-the-art mass spectrometry-based protein-protein interaction network including the noncanonical NF-kappaB (Montrer NFKB1 Anticorps) signaling nodes TRAF2 (Montrer TRAF2 Anticorps), TRAF3 (Montrer TRAF3 Anticorps), IKKalpha (Montrer CHUK Anticorps), NIK, and NF-kappaB2/p100 (Montrer CUX1 Anticorps); also provide a differential interactome of NIK mutants that cause immunodeficiency
OLFM1 (Montrer OLFM1 Anticorps) is a negative regulator of non-canonical NF-kappaB (Montrer NFKB1 Anticorps) signalling by interacting with and inhibiting NIK. Thus, OLFM1 (Montrer OLFM1 Anticorps) may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC (Montrer CALR Anticorps)) patients.
The expression of OTUD7B (Montrer OTUD7B Anticorps) and NIK were negatively correlated in non-small cell lung cancer tumor samples. the higher expression of NIK was related to more lymph node metastasis and later TNM (Montrer ODZ1 Anticorps) stage. high OTUD7B (Montrer OTUD7B Anticorps)/low NIK index can predict an good prognosis.
NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients.
This study identified two novel independent loci (MAP3K14 and CARD9 (Montrer CARD9 Anticorps)) strongly associated with joint damage in Mexican Americans and European Americans and a few shared loci showing suggestive evidence for association.
The forced expression of NDRG2 (Montrer NDRG2 Anticorps) in ATL cells down-regulates not only the canonical pathway by inhibiting AKT (Montrer AKT1 Anticorps) signaling but also the non-canonical pathway by inducing NF-kappaB (Montrer NFKB1 Anticorps)-inducing kinase (NIK) dephosphorylation via the recruitment of PP2A (Montrer PPP2R4 Anticorps)
NIK(+) endothelial cells may play an important role in the persistence of synovitis
Data suggest microRNA302c, but not microRNA520e, promotes replication of influenza A virus H3N2 although the two microRNAs target same site of NFkappaB (Montrer NFKB1 Anticorps)-inducing kinase (MAP3K14) 3prime untranslated region; studies were conducted in lung epithelial cells.
TWEAK (Montrer TNFSF12 Anticorps) induces noncanonical NF-kappaB (Montrer NFKB1 Anticorps) signaling and signal-specific regulation of NIK mRNA expression.
constitutive activation of NIK (Montrer MAP4K4 Anticorps) in the hematopoietic system leads to bone marrow (BM) failure and postnatal lethality.
results suggest that changes in the relative concentrations of RelB (Montrer RELB Anticorps), NIK:IKK1, and p100 (Montrer PATL2 Anticorps) during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100 (Montrer PATL2 Anticorps).
NIK (Montrer MAP4K4 Anticorps) pathways in both hepatocytes and immune cells act in concert to promote liver steatosis and glucose production in the setting of obesity.
this study demonstrates that although NIK (Montrer MAP4K4 Anticorps) is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells
Using a novel conditional mutant of NIK (Montrer MAP4K4 Anticorps), the authors could show in vivo that NIK (Montrer MAP4K4 Anticorps) signaling in thymic epithelial cells is essential for the thymic hardwiring of gammadelta T cell cytokine production.
NIK (Montrer MAP4K4 Anticorps) not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1 (Montrer TNFRSF1A Anticorps)/RIP1 (Montrer RALBP1 Anticorps)-dependent cell death independently of the alternative NF-kappaB (Montrer NFKB1 Anticorps) pathway.
This study demonstrated that NFkappaB-inducing kinase inhibits NFkappaB activity specifically in neurons of the CNS.
results assign NIK (Montrer MAP4K4 Anticorps)-induced alternative NF-kappaB (Montrer NFKB1 Anticorps) signaling a master regulatory role in B-cells, starting from the T1 stage and also show that B-1 B cells are less dependent on this pathway, presumably owing to the existence of alternative pathways yet to be determined
NIK (Montrer MAP4K4 Anticorps), and thus probably the noncanonical NF-kappaB (Montrer NFKB1 Anticorps) pathway, is critical to allow DCs to acquire the capacity to cross-present antigen and prime CD8 (Montrer CD8A Anticorps) T cells after exposure to licensing stimuli.
Deletion of NIK (Montrer MAP4K4 Anticorps) in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF (Montrer TNFSF13B Anticorps).
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
, serine/threonine protein-kinase
, serine/threonine-protein kinase NIK
, NF kappa B-inducing kinase
, Nfkb inducing kinase
, protein kinase
, mitogen-activated protein kinase kinase kinase 14