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anti-Rat (Rattus) MAP3K7 Anticorps:
anti-Human MAP3K7 Anticorps:
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Human Polyclonal MAP3K7 Primary Antibody pour DB - ABIN389721
Huang, Chiang, Hung, Hou: Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer. dans Oncotarget 2015
overexpression of miR (Montrer MLXIP Anticorps)-20a reduced colony formation and tumor growth. Furthermore, the data revealed that the function of miR (Montrer MLXIP Anticorps)-20a was probably exerted via targeting the TAK1 expression. Overexpression of miR (Montrer MLXIP Anticorps)-20a sensitizes the osteosarcoma cells to chemotherapeutic drugs.
TGFbeta (Montrer TGFB1 Anticorps) and IL1beta (Montrer IL1B Anticorps) signaling interact at the SMAD2 (Montrer SMAD2 Anticorps)/3 level in human primary MSC (Montrer MSC Anticorps). Down-stream TGFbeta (Montrer TGFB1 Anticorps) target genes were repressed by IL1beta (Montrer IL1B Anticorps) independent of C-terminal SMAD2 (Montrer SMAD2 Anticorps) phosphorylation. We demonstrate that SMAD2 (Montrer SMAD2 Anticorps)/3 linker modifications are required for this interplay and identified TAK1 as a crucial mediator of IL1beta (Montrer IL1B Anticorps)-induced TGFbeta (Montrer TGFB1 Anticorps) signal modulation.
increased TAK1 expression may be involved in the progression of gastric cancer.
miR (Montrer MLXIP Anticorps)-146a, serving as a tumor suppressor, may significantly promote GC cell apoptosis by inhibition of the NF-kappaB (Montrer NFKB1 Anticorps) signaling pathway via targeting TAK1.
In conclusion, for the first time, we report that TRADD (Montrer TRADD Anticorps), TRAF2 (Montrer TRAF2 Anticorps), RIP1 (Montrer UQCRFS1 Anticorps) and TAK1 play a role in the regulating TNF-alpha (Montrer TNF Anticorps) signalling in human myometrium. These findings are of significance given the central role of TNF-alpha (Montrer TNF Anticorps) in the processes of human labour and delivery.
Rab1 (Montrer RAB1A Anticorps) is regulated by the host in a similar fashion, and that the innate immunity kinase TAK1 and Legionella effectors compete to regulate Rab1 (Montrer RAB1A Anticorps) by switch II modifications during infection.
nMet accelerated HCC (Montrer FAM126A Anticorps) tumorigenesis and metastasis via the activation of TAK1/NF-kappaB (Montrer NFKB1 Anticorps) pathway.
TAK1 protein expression increased in cartilage tissue from spinal tuberculosis patients.
TAK1 regulates Nrf2 (Montrer GABPA Anticorps) through modulation of Keap-p62/SQSTM1 (Montrer SQSTM1 Anticorps) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Overexpression of TAK1 was strongly associated with positive lymph node metastasis in pancreatic ductal adenocarcinoma.
TAK1 (Montrer NR2C2 Anticorps) inhibits HBV primarily at viral transcription level through activation of MAPK (Montrer MAPK1 Anticorps)-JNK (Montrer MAPK8 Anticorps) pathway.
we generated the transgenic mouse line with deletion of Tak1 and gain of function of Bmpr1a. This compound mutation leads to more severe craniofacial deformities than each single mutation.
Data indicate TNF receptor associated factor 6 (TRAF6 (Montrer TRAF6 Anticorps)) as an essential molecular switch leading to cardiac hypertrophy in a transforming growth factor beta-activated kinase 1 (TAK1), -dependent manner.
It is a key regulator of the toll (Montrer TLR4 Anticorps)-like receptor signaling pathway.
The conversion of Tak1 (Montrer NR2C2 Anticorps)-B to Tak1 (Montrer NR2C2 Anticorps)-A consistently led to significant accumulation of lipids in cultured AML12cells, as well as the dysregulation of several lipid metabolism-related genes in mouse liver. Different functional properties of the two isoforms may explain the conflicting functions previously reported for Tak1 (Montrer NR2C2 Anticorps).
demonstrate the efficiency of ad--siRNA-TAK1 (Montrer NR2C2 Anticorps) in controlling joint inflammation of Collagen-Induced Arthritis, which is associated with the suppression of the expression of pro-inflammatory cytokines and JNK (Montrer MAPK8 Anticorps) activation.
These data, in addition to the fact that Map3k7 is upregulated in the sinus venous-the source of cells for the SAN-suggest that Map3k7 may be an endogenous regulator of the SAN fate
These results present a novel in vivo function, the negative role of TAK1 (Montrer NR2C2 Anticorps) in marginal zone B-cell development that is likely associated with NF-kappaB2 activation.
Tnfr1 (Montrer TNFRSF1A Anticorps) deletion partially restored thymic and lung macrophages.
TAK1 (Montrer NR2C2 Anticorps) is required for PPARgamma (Montrer PPARG Anticorps) transactivation and promotes PPARgamma (Montrer PPARG Anticorps) transcriptional activity synergistically with TAK1 binding protein 1 (TAB1 (Montrer TAB1 Anticorps)).
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1