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anti-Human TNFAIP3 Anticorps:
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Human Monoclonal TNFAIP3 Primary Antibody pour CyTOF, FACS - ABIN4277015
Kupfner, Arcaroli, Yum, Nadler, Yang, Abraham: Role of NF-kappaB in endotoxemia-induced alterations of lung neutrophil apoptosis. dans Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 38 Pubmed References
CHN1 and TNFAIP3 are candidate biomarkers for esophageal squamous cell carcinomas
These results identify the ubiquitin-editing enzyme A20 as a novel endogenous mechanism for negative regulation of fibrotic response intensity
Our data propose an additional novel mechanism to explain the known NF-kappaB inhibitory effects of A20: by affecting p105 ubiquitination and subsequently its degradation and limited processing.
A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1 (Montrer SNAI1 Anticorps).
Low TNFAIP3 expression is associated with colitis-associated colorectal cancer.
The miR-17-92 is a critical contributor to CML (Montrer BCR Anticorps) leukemogenesis via targeting A20 and activation of NF-kappaB (Montrer NFKB1 Anticorps) signaling.
IM could upregulate A20 protein to inhibit the activation of NF-kappaB (Montrer NFKB1 Anticorps) pathway in Jurkat T cells, which was independent of the ABIN1 (Montrer TNIP1 Anticorps) protein.
this meta-analysis confirms that TNFAIP3 gene polymorphisms may play important roles in the pathogenesis of Rheumatoid arthritis
Report a significant association between the biased usage of IGHV4-34 (binds to the carbohydrate I/i antigens) and inactivating mutation of TNFAIP3 [encoding a global negative regulator of the canonical nuclear factor-kappaB (NF-kappaB (Montrer NFKB1 Anticorps)) pathway] in ocular adnexal MALT lymphomas.
TNFAIP3 rs10499194 T allele and CT genotype were associated with an increased risk for AIH-1 (Montrer AMELX Anticorps)
holding thymic production of natural Treg cells in check, A20 integrates Treg cell activity and increased effector T cell survival into an efficient CD4 (Montrer CD4 Anticorps)(+) T cell response
these studies establish A20 as a crucial hepatoprotective factor.
These results suggested that A20 is involved in regulating intracerebral hemorrhage-induced inflammatory injury in both the central and peripheral system
the ubiquitin-modifying enzyme TNFAIP3/A20, an upstream regulator of T cell receptor (TCR) signaling in T cells, is an essential cell-intrinsic regulator of Natural killer T differentiation.
these data reveal a crucial role of A20 in regulating the immunomodulatory activities of mesenchymal stem cells.
Therefore, A20 acts as a novel endogenous regulator of STAT1 (Montrer STAT1 Anticorps) that prevents onset of enthesitis.
This study demonstrated that miR (Montrer MLXIP Anticorps)-136-5p affected the expression of A20 in IL-17 (Montrer IL17A Anticorps)-stimulated astrocytes.
Our data suggest that NAOs have a beneficial preventive effect in septic shock correlated with the enhancement of IL-10 (Montrer IL10 Anticorps) via the induction of A20 and COX-2 (Montrer COX2 Anticorps).
Forced expression of A20 resulted in decreased expression of key markers of lipogenesis and adipogenesis, such as sterol regulatory element binding protein (Montrer CNBP Anticorps) 1c (SREBP-1c (Montrer SREBF1 Anticorps)) and adipogenesis (aP2 (Montrer TFAP2A Anticorps)), leading to less lipids accumulation in differentiated 3T3-L1 cells
Data show the characterization and deduced amino acid sequence analysis for A20 gene which expression increases in MDBK cells infected by BVDV-1. Also, regulatory regions for NF-kappaB (Montrer NFKB1 Anticorps) and Sp-1 (Montrer SP1 Anticorps) additionally to an ARE element for mRNA stability were detected
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
tumor necrosis factor, alpha-induced protein 3
, OTU domain-containing protein 7C
, TNF alpha-induced protein 3
, putative DNA-binding protein A20
, tumor necrosis factor alpha-induced protein 3
, tumor necrosis factor inducible protein A20
, zinc finger protein A20
, tumor necrosis factor induced protein 3