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anti-Mouse (Murine) WNT10B Anticorps:
anti-Human WNT10B Anticorps:
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Human Polyclonal WNT10B Primary Antibody pour IHC, ELISA - ABIN1003488
Bennett, Hodge, MacDougald, Schwartz: Role of Wnt10b and C/EBPalpha in spontaneous adipogenesis of 243 cells. dans Biochemical and biophysical research communications 2003
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Human Polyclonal WNT10B Primary Antibody pour IF (p), IHC (p) - ABIN702295
Lu, Duan, Zhang, Wu, Wang: Expression of Wnt3a, Wnt10b, ?-catenin and DKK1 in periodontium during orthodontic tooth movement in rats. dans Acta odontologica Scandinavica 2015
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Human Polyclonal WNT10B Primary Antibody pour IHC (p), WB - ABIN541354
Lee, Lane, Kuo, Shackleford, Leder: Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice. dans Proceedings of the National Academy of Sciences of the United States of America 1995
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Human Polyclonal WNT10B Primary Antibody pour IHC, ELISA - ABIN1031166
Lim, Kim, Kim, Li, Kim, Park, Kim: Potential relationship between the canonical Wnt signalling pathway and expression of the vitamin D receptor in alopecia. dans Clinical and experimental dermatology 2014
Human Monoclonal WNT10B Primary Antibody pour ICC, IHC - ABIN969459
Saitoh, Kirikoshi, Mine, Katoh: Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45. dans International journal of oncology 2001
BMP6 and Wnt10b are major inhibitors and activators respectively and their balance regulates the telogen-anagen transition of hair follicles.
Treatment of secondary hyperparathyroidism with calcitriol improved the bone anabolism by inhibiting osteoclasts and promoting osteoblasts that might be achieved by increasing the Wnt 10b level.
Wnt10b recruitment to lipid rafts and mTOR activation promotes regeneration of injured optic nerve.
We examined a new culture condition for DPCs including addition of Wnt-10b, which promoted proliferation and maintained their HF induction ability for more than ten passages. These results suggest that Wnt-10b plays a pivotal role in proliferation and maintenance of DPCs in vitro
Wnt10b expression was assessed by flow cytometry under estrogen- and TNFalpha-deficient conditions.
AT2R inhibits adipogenic differentiation in mesenchymal stem cells. Moreover, this inhibitory effect is associated with Wnt10b/beta-catenin signaling.
XBP1s can regulate Wnt10b by a post-transcriptional mechanism through directly inducing microRNA-148a.
findings suggest that Wnt10b plays an important role in regulating asthmatic airway inflammation through modification of the T cell response and is a prospective target in the disease process
Data show that Wnt protein Wnt10b is expressed in cardiomyocytes and localized in the intercalated discs of mouse and human hearts.
Oleuropein protects mice from gh-fat diet induced adiposity by upregulation of genes involved in WNT10b-mediated signaling and downregulation of genes involved in galanin-mediated signaling cascades.
results suggest that Wnt-10b represses tumor cell properties, such as proliferation and migration of B16 melanoma cells, driving them toward a more differentiated state along a melanocyte lineage
Wnt10b/DKK1 can modulate hair follicle size during hair regeneration.
In senescent osteopenic mice, blocking the CADH2-Wnt interaction using an antagonist peptide increased Wnt5a and Wnt10b expression, bone formation, and bone mass.
Hypoxia-inducible factor-2alpha-dependent hypoxic induction of Wnt10b expression in adipogenic cells.
Data suggest that Tgfb1 (transforming growth factor beta 1) induces Wnt10b in osteoclasts; induction of Wnt10b may enhance restoration of bone lost during bone turnover and may explain osteoclast stimulation of osteoblast-directed mineralization.
Wnt-10b promoted cell proliferation and trichogenesis, while Wnt-3a showed those abilities to a limited extent
Wnt10b promotes the differentiation of melanocytes by activating canonical Wnt signaling in melanocytes
Ex vivo analysis showed decreased basal and Wnt3a-induced Wnt5a and Wnt10b mRNA expression in FHL2-deficient bone marrow cells, further indicating that this defect may contribute to the reduced osteoblast function in FHL2 deficient mice
Direct binding of XBP1 to the Wnt10b promoter and the subsequent decrease of the beta-catenin signalling pathway represent a novel adipogenic differentiation mechanism.
It was shown that Wnt10b induces hair follicle regeneration in vivo via the enhanced activation of the canonical Wnt signaling pathway. In Wnt10b-induced hair follicles, beta-catenin was translocated to the nucleus.
In 7 families afflicted with dental anomalies we detected 4 heterozygous missense variants in WNT10B. We performed whole exome sequencing in the patients who had WNT10B mutations and found no mutations in other known hypodontia-associated genes..They also show that WNT10B variants are associated not only with oligodontia and isolated tooth agenesis, but also with microdontia, short tooth roots, dental pulp stones
Significant associations were found between individual SNPs and SNP combinations in WNT10A, WNT10B and GREM2 SNPs with isolated tooth agenesis.
We report an Indian girl with split-hand/foot malformation (SHFM), sparse hair, and interrupted eyebrows, who carries a novel homozygous deletion c.695_697delACA in WNT10B. The variant is deduced to cause an in-frame deletion of Asn residue 232 (p.Asn232del).
Wnt10b is involved in forskolin/hCG-mediated BeWo cell fusion via beta-catenin/GCMa/syncytin pathway, which may also involve activation of PKA
These results present the first evidence for a recurrent rearrangement promoted by a mobile ht-WNT10B oncogene, as a relevant mechanism for Wnt involvement in human cancer.
High expression of WNT10B is associated with epithelial-mesenchymal transition and invasion of pancreatic cancer.
this study provides novel insight into the mechanism of action of parathyroid hormone on human periodontal ligament cells and establish their interplay with T cells via the Wnt10b pathway as a modulating factor for the anabolic properties of the hormone in periodontal regeneration
findings provide the identification of autosomal-dominant WNT10B mutations in individuals with oligodontia, which increases the spectrum of congenital tooth agenesis and suggests attenuated Wnt signaling in endothelial differentiation of dental pulp stem cells.
these findings clearly demonstrate that Wnt10b promotes epidermal keratinocyte transformation through induced Egf pathway
WNT10B enhances proliferation through beta-catenin and RAC1 GTPase in human corneal endothelial cells.
Sequence analysis of WNT10B gene revealed a novel 4-bp deletion mutation.
No association between WNT10B polymorphisms and adiposity parameters was found. However, a role for WNT10B variants in determining human bone mineral density was found.
Variations in WNT10B do not contribute to human monogenic obesity in our population.
we identified WNT10B as a direct target of miR-148a in cancer-associated fibroblasts from endometrial cancers
WNT10B/beta-catenin signalling induces HMGA2 and proliferation in metastatic breast cancer tumours devoid of ERalpha, PR and HER2 expression.
Results suggest that Wnt10b likely plays an important role in the development of endometrial cancer (EC). The results also identify a role for Wnt10b in EC cells through promoting proliferation and inhibiting apoptosis.
A novel sequence variant (c.986C>G, p.Thr329Arg) of WNT10B has been identified in familial split-hand/foot malformations in a large consanguineous Pakistani family.
Results indicate that the porcine WNT10B gene may be a very important candidate gene for porcine backfat thickness.
In the zebrafish, wnt1 and its neighboring paralog, wnt10b, are expressed in largely overlapping patterns, suggesting co-regulation; results suggest that the control of wnt1 and wnt10b expression is under complex regulation involving the interaction of multiple enhancers.
wnt1 and wnt10b are required to maintain threshold levels of Pax2.1 and Fgf8 at the midbrain-hindbrain boundary.
In zebrafish embryos lacking Wnt3a, Wnt1 and Wnt10b, the expression of engrailed orthologs, pax2a and fgf8 is not maintained after mid-somitogenesis
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.
wingless-type MMTV integration site family, member 10B
, protein Wnt-10b
, WNT-10B protein
, wingless related MMTV integration site 10b
, Protein Wnt-10
, wnt-1 related (wnt-10), wingless-type MMTV integration site family