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anti-Mouse (Murine) SKAP1 Anticorps:
anti-Human SKAP1 Anticorps:
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Human Monoclonal SKAP1 Primary Antibody pour IF, WB - ABIN968435
Liu, Kang, Raab, da Silva, Kraeft, Rudd: FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. dans Proceedings of the National Academy of Sciences of the United States of America 1998
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Human Polyclonal SKAP1 Primary Antibody pour ICC, IF - ABIN4353952
van Doorn, van Kester, Dijkman, Vermeer, Mulder, Szuhai, Knijnenburg, Boer, Willemze, Tensen: Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome. dans Blood 2009
SKAP1 can affect the function of talin in T-cells needed for optimal T-cell/dendritic cell conjugation
this study shows that Skap1-deficient (skap1-/-) mice are highly resistant to the induction of collagen-induced arthritis
In this study, the authors identified that the ADAP (Montrer APP Anticorps)-SKAP55 signaling module reduced CD8 (Montrer CD8A Anticorps)(+) cytotoxic T lymphocyte cytotoxicity and enhanced PD-1 (Montrer PDCD1 Anticorps) expression in a Fyn (Montrer FYN Anticorps)-, Ca(2 (Montrer CA2 Anticorps)+)-, and NFATc1 (Montrer NFATC1 Anticorps)-dependent manner.
Data suggest that the presence or absence of associated SKAP55 defines functionally distinct pools of ADAP (Montrer APP Anticorps).
HPK1 (Montrer MAP4K1 Anticorps) associates with SKAP1 to negatively regulate Rap1 (Montrer TERF2IP Anticorps)-mediated B-lymphocyte (Montrer AKAP17A Anticorps) adhesion.
SKAP1 is dispensable for both CXCL12 (Montrer CXCL12 Anticorps) and CCL21 (Montrer CCL21 Anticorps) induced T-cell migration.
findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL (Montrer RASSF5 Anticorps) that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes.
Results identify a clear effector role for SKAP-55 in LFA-1 adhesion in peripheral T cells and demonstrate that dependency on SKAP-55 and ADAP differs among T cells and differs with the strength of the TCR signal.
K152 and D120 within the PH domain of SKAP55 regulate plasma membrane targeting and T cell receptor-mediated activation of LFA-1 (Montrer ITGAL Anticorps).
SKAP55 dimers stabilize SLP-76 (Montrer LCP2 Anticorps) microclusters, couple SLP-76 (Montrer LCP2 Anticorps) to the force-generating systems responsible for microcluster movement, and enable adhesion via the TCR by mechanisms independent of RIAM (Montrer APBB1IP Anticorps), talin, and beta1 integrins.
single-nucleotide polymorphisms in ARRDC3, FLT1 (Montrer FLT1 Anticorps), and SKAP1 were significant predictors for survival androgen-deprivation therapy in prostate cancer patients.
N-terminal myr-tagged SKAP1 for membrane binding facilitated constitutive RapL (Montrer RASSF5 Anticorps) membrane and Rap1 (Montrer RABGEF1 Anticorps) binding and effectively substituted for PI3K (Montrer PIK3CA Anticorps) and TCR ligation in the activation of LFA-1 (Montrer ITGAL Anticorps) in T cells.
Single nucleotide polymorphism in SKAP1 is associated with ovarian cancer.
SKAP55 coupled with CD45 (Montrer PTPRC Anticorps) positively regulates T-cell receptor-mediated gene transcription.
observation that adapter protein (Montrer TOLLIP Anticorps) SKAP55 formed homodimers through its SH3 domain (Montrer ITSN1 Anticorps) and SK region
SKAP-55 regulates integrin-mediated adhesion and conjugate formation between T cells and antigen-presenting cells
stimuli that signal for the stabilization of SKAP55 may play an important role in T cell adhesion and conjugate formation
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.
ortholog of human src family associated phosphoprotein 1 SCAP1
, src family-associated phosphoprotein 1
, src kinase-associated phosphoprotein 1
, src family associated phosphoprotein 1
, src kinase-associated phosphoprotein of 55 kDa
, SKAP55 adapter protein
, SKAP55 adaptor protein