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we measured 21 serum proteins related to HCMV infection using iTRAQ-labeling based quantitative proteomic approaches and SAA1 and APOE were confirmed as candidate serum indicators for identification of HMCV infection according to ROC curve analysis and that co-occurrence of SAA1 and APOE are better markers than individual proteins.
Here, we report that mice with inducible transgenic expression of human SAA1 are partially protected against inflammatory response and lung injury caused by LPS and cecal ligation and puncture (CLP). In comparison, transgenic SAA1 does not attenuate TNFa-induced lung inflammation and injury
SAA1 in combination with integrin alphaV and beta3 can serve as an indicator of high glioblastoma risk.
Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks.
The frequency of the SAA1.3 allele was increased in adult-onset Still's disease (AOSD) patients compared with that in healthy subjects but the difference was not significant. The -13T allele was more frequently observed in AOSD patients than in healthy subjects. AOSD patients with the -13T allele had been treated with immunosuppressants more frequently than those without this allele.
SAA1 can be produced in human fetal membranes, which can be greatly induced in the presence of proinflammatory cytokines and glucocorticoids thereby producing effects associated with parturition
High SAA1 expression in the stromal component is associated with pancreatic tumors.
Data suggest that anti-inflammatory capacity of HDL (high-density lipoprotein) from patients with type 2 diabetes and diabetic nephropathy is impaired; this effect might be attributable to SAA enrichment in HDL in these patients; up-regulation of SAA in HDL appears to be associated with increased risk of diabetic angiopathy or vasculitis in such patients.
The frequencies of the CC genotype and the C allele of SAA rs12218 were higher in participants with ischemic stroke than in the control group. The frequencies of the AG genotype and the G allele of rs2468844 were higher in participants with ischemic stroke than in the control group. Multiple logistic regression analysis revealed the significance of the rs12218 in males and in large-artery atherosclerosis group.
we show that astrocytoma patients have increased levels of serum SAA and SAA1 is expressed and secreted in glioblastoma, and its co-expression with tumor-related genes supports its involvement in glioblastoma angiogenesis and progression.
These results suggested that the C-terminal truncation of human SAA accelerates amyloid fibril formation.
SAA1 can be a potential mediator for UV-induced MMP-1 expression in human skin.
Data suggest that serum amyloid A (SAA) immunoreactivity in tumor-associated macrophage (TAM) is associated with worse recurrence-free survival, and is perhaps a therapeutic target for breast cancer.
Findings indicate that in Lyme disease patients, circulating CRP and SAA (Serum Amyloid A) levels are highest when the concentration of spirochetes is greatest in skin and/or blood and that levels decline after the dissemination of the organism to extracutaneous sites in subsequent stages of infection.
The Serum amyloid A (SAA)/formyl peptide receptor-like 1 (FPRL1) contributed to pathogenesis of psoriasis by promoting keratinocyte proliferation and inflammation, thus providing a potential therapeutic target for disease therapy.
High SAA expression is associated with lung cancer.
SAA, PROZ, and C4BPB may serve as new potential biomarkers for TB
Novel truncated form of serum amyloid A is elevated in the plasma of Kawasaki disease (KD) when compared with Febrile control subjects. Future studies will evaluate its relevance as a diagnostic biomarker and its potential role in the pathophysiology of KD.
SR-A1 suppresses lung cancer metastasis by downregulating SAA1 production in tumor-associated macrophages (TAM).
The SAA1.1 allele was found in four familial Mediterranean fever patients, including two with AA amyloidosis.
endometritis gives rise to a systemic acute phase response and an up-regulated endometrial gene expression of SAA and several pro-and anti-inflammatory cytokines
The levels of surfactant protein D and serum amyloid A protein in normal horses and those with bacterial pneumonia are reported.
This study confirmed that SAA1 was a prominent protein that increased IL-17 levels through TLR2 in gammadelta T cells, confirming the possibility that SAA1 may exacerbate inflammatory diseases through gammadelta T cells.
the present work demonstrates an important role for SAA in epithelial wound recovery and provides evidence for a physiological role in the wound environment.
Study concludes that the transfer of serum amyloid A1 protein depends on direct cell-to-cell contacts or tunneling nanotubes.
findings show that high-density lipoprotein binding blocks fibril formation from soluble SAA1 protein, whereas internalization into mononuclear phagocytes leads to formation of amyloid; SAA1 aggregation in the cell model disturbs the integrity of vesicular membranes and leads to lysosomal leakage and apoptotic death
These findings suggest that A-SAA is functionally linked to pulmonary inflammation in this O3 exposure model and that A-SAA could be an important systemic signal of O3 exposure to the CNS.-
SAA and TLR4 have a role in skin inflammation
Data indicate that SAA1 overexpressing mice (TG) show significant deficits in social behaviors, including impaired social recognition and reduced social interaction. Study detected exogenous SAA1 expression in the brain of TG mice, implying that liver-derived SAA1 migrates to the brain. Results show an increase in the accumulation of the 87kDa form of Abeta in TG mice compared to wild type mice.
Sustained, elevated levels of SAA1 were correlated with metabolic parameters and local cytokine expression in the liver following 16 weeks on the high-fat diet. We suggest that SAA1-derived amyloid deposition under long-term high-fat diet exposure may be associated with the complications of high-fat diet-induced obesity and metabolic disorders.
Serum Amyloid A induces inflammation, proliferation and cell death in activated hepatic stellate cells.
Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL
SAA1/2 produced by macrophages promotes early lesion formation in the ascending aorta in LDLR knockout mice.
Serum amyloid A1alpha induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils.
Robust IL-17A production was restricted to the ileum, where SFB makes direct contact with the epithelium and induces serum amyloid A proteins 1 and 2 (SAA1/2), which promote local IL-17A expression in RORgammat(+) T17 cells.
SAA protein levels increased in both serum and lung within 2-24h after mice were exposed to Aspergillus spores. SAA mRNA levels increased within the first hour after mice were exposed to A. fumigatus.
Saa1 might be a novel inflammatory factor that acts as a chemokine modulator in hepatitis.
GAGs may have an intrinsic and divergent influence on the aggregation and fibrillation of HDL-free SAA1.1 in vivo
CE/J mice possess functional Saa1 and Saa2 genes with identical amino acid sequence.
we find no evidence that adipose tissue-derived hSAA1 influences the development of insulin resistance or obesity-related inflammation.
Its gene hold broader diversity and greater complexity and these characteristics were likely attained through gene duplication and repeated gene conversion events in the Mus lineage.
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
serum amyloid A protein
, serum amyloid A-1 protein
, tumor protein p53 inducible protein 4
, serum amyloid A1
, serum amyloid A
, serum amyloid a protein
, serum amyloid A 2