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anti-Human MTTP Anticorps:
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Cow (Bovine) Polyclonal MTTP Primary Antibody pour WB - ABIN2781495
Lundahl, Skoglund-Andersson, Caslake, Bedford, Stewart, Hamsten, Packard, Karpe: Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles. dans American journal of physiology. Endocrinology and metabolism 2006
Show all 3 Pubmed References
Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB (Montrer APOB Anticorps) genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B (Montrer SAR1B Anticorps), which encodes the gene causing chylomicron retention disease
Deleterious and protective mutations in MTTP, PNPLA3, and TM6SF2 have been found in Japanese males at risk for non-alcoholic fatty liver disease.
The authors conclude that alternate splicing plays a key role in regulating cellular MTP (Montrer MT1B Anticorps) levels by introducing distinct promoter regions and unique 5'-UTRs, which contain elements that alter translation efficiency, enabling the cell to optimize MTP (Montrer MT1B Anticorps) activity.
these data reveal clear cellular defects in induced pluripotent stem cells-derived hepatocytes and cardiomyocytes lacking MTTP activity, including a cardiomyocyte-specific regulated stress response to elevated lipids.
two new hypolipidemic patients with very low plasma triglyceride and apolipoprotein B (apoB (Montrer APOB Anticorps)) levels with plasma lipid profiles similar to abetalipoproteinemia (ABL (Montrer ABL1 Anticorps)) patients, are reported.
results of this study, examining a cohort of obese children, suggest that the genetic variation at MTTP rs2306986 was associated with higher susceptibility to NAFLD (Montrer TSC2 Anticorps)
Data suggest that amphipathic beta-strands in 200 N-terminal residues of beta1 domain of APOB (Montrer APOB Anticorps) are required for secretion of lipid-rich or lipid-poor particles; residues 300-700 or 1050-1500 of beta1 domain appear to be required for secretion of lipid-rich particles; MTTP is required for secretion of intact APOB (Montrer APOB Anticorps) but not of truncated APOB (Montrer APOB Anticorps). (APOB (Montrer APOB Anticorps) = apolipoprotein B (Montrer APOB Anticorps); MTTP = microsomal triglyceride transfer protein)
In chronic hepatitis C patients infected with HCV genotype 3 and with the TT/GT genotype of the MTTP -493G/T SNP, a significant increase in hepatic steatosis was observed, which may indicate that this SNP has a significant influence on the accumulation of triglycerides in hepatocytes.
High expression of MTTP is associated with high carotid intima-media thickness.
MTP (Montrer MT1B Anticorps) Gene Variants are associated with Homozygous Familial Hypercholesterolemia.
microsomal triglyceride transfer protein, a protein involved in the transfer of lipids onto CD1d (Montrer CD1D Anticorps), regulates liver natural killer T cell homeostasis in a manner dependent on hepatocyte CD1d (Montrer CD1D Anticorps).
Microsomal triglyceride transfer protein protein plays a critical role in lipid droplet maturation, but does not regulate total body fat accumulation.
data provide the first in vivo evidence of the transcriptional regulatory activity of beta-apocarotenoids and identify microsomal triglyceride transfer protein and its transcription factors as the targets of their action. This study demonstrates that beta-carotene induces a feed-forward mechanism in the placenta to enhance the assimilation of beta-carotene for proper embryogenesis.
PHARMACOLOGICAL STUDY OF NEW COMPOUNDS ACTING AS REGULATORS OF 18-KDA TRANSLOCATOR PROTEIN (Montrer TSPO Anticorps) LIGANDS
Intestine-specific MTP (Montrer LAPTM4A Anticorps) and global ACAT2 (Montrer SOAT2 Anticorps) deficiency lowers acute cholesterol absorption with chylomicrons and HDLs (Montrer CSF1R Anticorps)
intestine-specific Mttp deletion is beneficial in young septic mice but harmful in aged mice
identified microsomal triglyceride transfer protein, which we show is also under the transcriptional regulation of C/EBPbeta (Montrer CEBPB Anticorps) and -delta, as a novel player in the presentation of endogenous lipid antigens by adipocytes
effects of reducing either systemic or liver-specific MTP (Montrer LAPTM4A Anticorps) activity on cholesterol metabolism and reverse cholesterol transport
Data show that combined deletion of microsomal triglyceride transfer protein (Mttp) and liver fatty acid binding protein 1 (L-Fabp (Montrer FABP1 Anticorps)) are protected from lithogenic diet (LD)-induced gallstone formation.
FoxO6 (Montrer Foxo6 Anticorps) is an important signaling molecule upstream of MTP (Montrer LAPTM4A Anticorps) for regulating hepatic VLDL-TG production
promotes assembly and secretion of human apolipoprotein B (Montrer APOB Anticorps)
the phospholipid transfer activity of MTP is sufficient for the assembly and secretion of primordial apoB (Montrer APOB Anticorps) lipoproteins
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (Montrer APOB Anticorps), ApoE (Montrer APOE Anticorps), MTP, and LDLR (Montrer LDLR Anticorps), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
after calving the apolipoprotein B(100 (Montrer APOB Anticorps)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E (Montrer APOE Anticorps) messenger RNA abundance were higher in the liver
measurements of the transfer of phospholipids (PLs (Montrer CTSC Anticorps)) and cholesteryl esters (CEs)to acceptor vesicles by purified MTP showed TAG transfer activity was the most robust, and CE and PL transfer activities were 60-71% and 5-13% of the TAG transfer activity
MTTP is regulated by apo A-IV in manner to promote increased packaging of triglyceride into chylomicron core, which may be important in neonatal fat absorption.
There appears to be an interaction between the porcine MTTP genotype and the type of fat source in the pig diet, which would agree with the previous results on the biology of MTTP biology.
analysis of developmental expression and nutritional regulation of zebrafish homolog to mammalian microsomal triglyceride transfer protein large subunit
In a genetic study of lipid transport and metabolism, larval levels of microsomal triglyceride transfer protein (Mtp), the protein responsible for packaging triacylglycerol and beta-lipoproteins into lipoprotein particles, are unchanged by feeding.
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
microsomal triglyceride transfer protein (large polypeptide, 88kDa)
, microsomal triglyceride transfer protein large subunit
, microsomal triglyceride transfer protein B
, microsomal triglyceride transfer protein, large subunit
, microsomal triacylglycerol transfer protein
, microsomal triglyceride transfer protein