anti-Synuclein, alpha Interacting Protein (SNCAIP) Anticorps

SNCAIP encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. De plus, nous expédions SNCAIP Protéines (6) et SNCAIP Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SNCAIP 9627 Q9Y6H5
SNCAIP 307309  
SNCAIP 67847  
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Top anti-SNCAIP Anticorps sur anticorps-enligne.fr

Showing 10 out of 60 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué EIA, WB The anti-Synphilin-1 C-term Pab is used in Western blot to detect Synphilin-1 in mouse brain lysate. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-Synphilin-1 Polyclonal Antibody, Unconjugated (ABIN736163) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Rat brain lysates probed with Anti Synphilin-1 Polyclonal Antibody, Unconjugated (ABIN736163) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 100kD. Observed band size:60kD 100kD. 100 μL Connectez-vous pour afficher 9 to 12 Days
304,36 €
Détails
Humain Lapin Inconjugué WB The anti-Synphilin-1 C-term Pab (ABIN390382) is used in Western blot to detect Synphilin-1 in mouse brain lysate. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué ELISA, IHC, WB 100 μL Connectez-vous pour afficher 13 Days
154,33 €
Détails
Humain Lapin Inconjugué IHC, WB Immunohistochemical analysis of Synphilin 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Synphilin 1 expression in HeLa (A), U2OS (B) whole cell lysates. 200 μL Connectez-vous pour afficher 11 to 13 Days
464,29 €
Détails
Humain Lapin Alexa Fluor 594 IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails
Humain Lapin HRP IHC (p), WB   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails
Humain Lapin Cy7 IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails
Humain Lapin FITC IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails
Humain Lapin Cy3 IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails

SNCAIP Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-SNCAIP Anticorps mieux référencés

  1. Human Polyclonal SNCAIP Primary Antibody pour IF, IHC (p) - ABIN2476664 : Büttner, Delay, Franssens, Bammens, Ruli, Zaunschirm, de Oliveira, Outeiro, Madeo, Buée, Galas, Winderickx: Synphilin-1 enhances ?-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. dans PLoS ONE 2010 (PubMed)

Plus d’anticorps contre SNCAIP partenaires d’interaction

Human Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

  1. Differential expression of synphilin-1 isoforms (and alpha-synuclein (Montrer SNCA Anticorps) and parkin (Montrer PARK2 Anticorps)) was found in multiple system atrophy brains compared to control brain.

  2. Synphilin-1 binds ATP, but not CTP (Montrer CDS1 Anticorps).

  3. Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity.

  4. Overexpression of SP1 (Montrer PSG1 Anticorps) in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 (Montrer PSG1 Anticorps) increased food intake but did not affect locomotor activity

  5. Although serine-129 phosphorylation of alpha-synuclein (Montrer SNCA Anticorps) facilitates tubulin polymerization promoting protein (TPPP (Montrer Tppp Anticorps))-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation.

  6. Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease.

  7. Neuronal survival factor MEF2D (Montrer MEF2D Anticorps) is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein (Montrer SNCA Anticorps) accumulation and aggregation.

  8. Synphilin-1 inhibits alpha-synuclein (Montrer SNCA Anticorps) degradation by the proteasome.

  9. Knockdown of Herp (Montrer HERPUD1 Anticorps) gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition.

  10. Data show that periphilin (Montrer PPHLN1 Anticorps) displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin (Montrer PPHLN1 Anticorps) in PD.

Mouse (Murine) Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

  1. This study shows that alpha-synuclein (Montrer SNCA Anticorps) is present in cerebellar glutamatergic terminals.

  2. These results suggest that increased levels of NUB1 (Montrer NPM3 Anticorps) play a potential role in degradation of detergent-insoluble alpha-synuclein (Montrer SNCA Anticorps) in vivo, although it is insufficient to degrade abnormal alpha-synuclein (Montrer SNCA Anticorps) in Lewy body disease model mice.

  3. SP1 (Montrer SP1 Anticorps) results in a CCK (Montrer CCK Anticorps) response deficiency that may contribute to the increased meal size and overall hyperphagia in synphillin-1 transgenic mice

  4. TEM (Montrer TNMD Anticorps) analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of alpha-synuclein (Montrer SNCA Anticorps), suggesting the therapeutic potential of the small molecule in PD.

  5. We exploited atomic force microscopy (AFM (Montrer AFM Anticorps)) for the selective, nanoscale confinement of alpha-Synuclein (Montrer SNCA Anticorps) on gold to study the early stages of alpha-Synuclein (Montrer SNCA Anticorps) aggregation and the effect of small molecules, like dopamine, on the aggregation process.

  6. Sncaip physically interacts with PPP1 and affects PPP1 sorting to subcellular compartments.

  7. Studies identify a novel function of synphilin-1 in controlling food intake and body weight, and may provide a unique obesity model for future studies of obesity pathogenesis and therapeutics.

  8. Synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein (Montrer SNCA Anticorps) toxicity in vivo.

  9. synphilin-1 has a role in skill learning and motor performance

  10. expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease

SNCAIP profil antigène

Profil protéine

This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined.

Gene names and symbols associated with SNCAIP

  • synuclein, alpha interacting protein (SNCAIP) anticorps
  • synuclein, alpha interacting protein (synphilin) (sncaip) anticorps
  • synuclein, alpha interacting protein (sncaip) anticorps
  • synuclein, alpha interacting protein (synphilin) (LOC100221074) anticorps
  • synuclein, alpha interacting protein (Sncaip) anticorps
  • synuclein, alpha interacting protein (synphilin) (Sncaip) anticorps
  • 2810407O15Rik anticorps
  • 4933427B05Rik anticorps
  • BB104594 anticorps
  • LOC100221074 anticorps
  • MGC88953 anticorps
  • SNCAIP anticorps
  • Sph1 anticorps
  • Syph1 anticorps

Protein level used designations for SNCAIP

synuclein, alpha interacting protein , synuclein, alpha interacting protein (synphilin) , synphilin-1-like , alpha-synuclein-interacting protein , synphilin-1 , synuclein alpha interacting protein , synphilin-1 variant 1e

GENE ID SPECIES
100063985 Equus caballus
448237 Xenopus (Silurana) tropicalis
700372 Macaca mulatta
462021 Pan troglodytes
100406168 Callithrix jacchus
100481199 Ailuropoda melanoleuca
100559476 Anolis carolinensis
100221074 Taeniopygia guttata
9627 Homo sapiens
307309 Rattus norvegicus
426796 Gallus gallus
100720184 Cavia porcellus
67847 Mus musculus
481479 Canis lupus familiaris
100049698 Sus scrofa
540156 Bos taurus
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