Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
SNCAIP encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. De plus, nous expédions SNCAIP Protéines (6) et SNCAIP Kits (2) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 60 products:
Human Polyclonal SNCAIP Primary Antibody pour IF, IHC (p) - ABIN2476664
Büttner, Delay, Franssens, Bammens, Ruli, Zaunschirm, de Oliveira, Outeiro, Madeo, Buée, Galas, Winderickx: Synphilin-1 enhances ?-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. dans PLoS ONE 2010
Differential expression of synphilin-1 isoforms (and alpha-synuclein (Montrer SNCA Anticorps) and parkin (Montrer PARK2 Anticorps)) was found in multiple system atrophy brains compared to control brain.
Synphilin-1 binds ATP, but not CTP (Montrer CDS1 Anticorps).
Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity.
Overexpression of SP1 (Montrer PSG1 Anticorps) in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 (Montrer PSG1 Anticorps) increased food intake but did not affect locomotor activity
Although serine-129 phosphorylation of alpha-synuclein (Montrer SNCA Anticorps) facilitates tubulin polymerization promoting protein (TPPP (Montrer Tppp Anticorps))-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation.
Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease.
Neuronal survival factor MEF2D (Montrer MEF2D Anticorps) is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein (Montrer SNCA Anticorps) accumulation and aggregation.
Synphilin-1 inhibits alpha-synuclein (Montrer SNCA Anticorps) degradation by the proteasome.
Knockdown of Herp (Montrer HERPUD1 Anticorps) gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition.
Data show that periphilin (Montrer PPHLN1 Anticorps) displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin (Montrer PPHLN1 Anticorps) in PD.
This study shows that alpha-synuclein (Montrer SNCA Anticorps) is present in cerebellar glutamatergic terminals.
These results suggest that increased levels of NUB1 (Montrer NPM3 Anticorps) play a potential role in degradation of detergent-insoluble alpha-synuclein (Montrer SNCA Anticorps) in vivo, although it is insufficient to degrade abnormal alpha-synuclein (Montrer SNCA Anticorps) in Lewy body disease model mice.
SP1 (Montrer SP1 Anticorps) results in a CCK (Montrer CCK Anticorps) response deficiency that may contribute to the increased meal size and overall hyperphagia in synphillin-1 transgenic mice
TEM (Montrer TNMD Anticorps) analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of alpha-synuclein (Montrer SNCA Anticorps), suggesting the therapeutic potential of the small molecule in PD.
We exploited atomic force microscopy (AFM (Montrer AFM Anticorps)) for the selective, nanoscale confinement of alpha-Synuclein (Montrer SNCA Anticorps) on gold to study the early stages of alpha-Synuclein (Montrer SNCA Anticorps) aggregation and the effect of small molecules, like dopamine, on the aggregation process.
Sncaip physically interacts with PPP1 and affects PPP1 sorting to subcellular compartments.
Studies identify a novel function of synphilin-1 in controlling food intake and body weight, and may provide a unique obesity model for future studies of obesity pathogenesis and therapeutics.
Synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein (Montrer SNCA Anticorps) toxicity in vivo.
synphilin-1 has a role in skill learning and motor performance
expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined.
synuclein, alpha interacting protein
, synuclein, alpha interacting protein (synphilin)
, alpha-synuclein-interacting protein
, synuclein alpha interacting protein
, synphilin-1 variant 1e