TRADD anticorps (AA 163-312)
-
- Antigène Voir toutes TRADD Anticorps
- TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))
-
Épitope
- AA 163-312
-
Reactivité
- Humain, Rat
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp TRADD est non-conjugé
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- Réactivité croisée
- Rat (Rattus)
- Attributs du produit
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human TRADD aa. 163-312
- Clone
- 37-TRADD
- Isotype
- IgG1
- Top Product
- Discover our top product TRADD Anticorps primaire
-
-
- Commentaires
-
Related Products: ABIN968537, ABIN967389
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20° C.
-
-
A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells." dans: Molecular and cellular biology, Vol. 22, Issue 17, pp. 6034-45, (2002) (PubMed).
: "Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms." dans: The Journal of cell biology, Vol. 157, Issue 6, pp. 975-84, (2002) (PubMed).
: "Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells." dans: Oncogene, Vol. 20, Issue 22, pp. 2826-35, (2001) (PubMed).
: "Systematic mutational analysis of the death domain of the tumor necrosis factor receptor 1-associated protein TRADD." dans: The Journal of biological chemistry, Vol. 271, Issue 16, pp. 9858-62, (1996) (PubMed).
: "
-
A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells." dans: Molecular and cellular biology, Vol. 22, Issue 17, pp. 6034-45, (2002) (PubMed).
-
- Antigène
- TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))
- Autre désignation
- TRADD (TRADD Produits)
- Synonymes
- anticorps TRADD, anticorps Hs.89862, anticorps 9130005N23Rik, anticorps AA930854, anticorps wu:fc59e02, anticorps zgc:103556, anticorps tradd, anticorps TNFRSF1A associated via death domain, anticorps conjugal transfer protein D, anticorps TNFRSF1A-associated via death domain, anticorps TNFRSF1A-associated via death domain L homeolog, anticorps tnfrsf1a-associated via death domain, anticorps TRADD, anticorps traDd, anticorps Tradd, anticorps tradd.L, anticorps tradd
- Sujet
-
TNFalpha (Tumor Necrosis Factor) stimulates programmed cell death and NF-kappaB activation as a result of its binding to the TNF receptor 1 (TNFR1). Within this receptor, a sequence referred to as the death domain” has been shown to be necessary for both of these functions. Using the yeast two-hybrid system to detect proteins which interact with the receptor through this death domain”, a 34 kDa protein was found and designated TRADD (TNFR1-Associated Death Domain protein). TRADD appears to contain no intrinsic catalytic activity. It also contains a death domain and it has been shown to bind to FADD and RIP. Mutational analysis of TRADD demonstrates that programmed cell death and NF-kappaB activation are distinct and controlled independently.
Synonyms: TNFR1-Associated Death Domain protein - Poids moléculaire
- 34 kDa
- Pathways
- Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Hepatitis C
-