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Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. De plus, nous expédions ACER1 Protéines (3) et beaucoup plus de produits pour cette protéine.
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regulates the signaling system mediated by sphingolipids
upregulation of haCER1 and AC mediates the Ca2+(o)-induced growth arrest and differentiation of keratinocytes by generating sphingosine and its phosphate
Loss of Acer1 elevated the levels of various ceramides and sphingoid bases in the skin and caused progressive hair loss in mice.
In conclusion, the present study unraveled ceramidase as a crucial player in sphingosine-induced platelet activation following GPVI-dependent signaling.
novel alkaline ceramidase with a stringent substrate specificity and is selectively expressed in skin and may have a role in regulating the levels of bioactive lipids ceramide and sphingosine-1-p, as well as complex sphingolipids.
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006
N-acylsphingosine amidohydrolase (alkaline ceramidase) 3
, alkaline ceramidase 1
, N-acylsphingosine amidohydrolase 3
, acylsphingosine deacylase 3
, alkCDase 1
, alkaline CDase 1
, alkaline cdase 1