anti-CD2-Associated Protein (Cd2ap) Anticorps

Cd2ap encodes a scaffolding molecule that regulates the actin cytoskeleton. De plus, nous expédions CD2-Associated Protein Protéines (7) et CD2-Associated Protein Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
Cd2ap 23607 Q9Y5K6
Cd2ap 12488 Q9JLQ0
Cd2ap 316258  
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Top anti-CD2-Associated Protein Anticorps sur anticorps-enligne.fr

Showing 10 out of 60 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), WB WB Image CD2AP antibody detects CD2AP protein by Western blot analysis. A. 30 µg Rat2 whole cell lysate/extract 7.5 % SDS-PAGE CD2AP antibody , dilution: 1:1000 WB Image CD2AP antibody detects CD2AP protein by Western blot analysis. A. 30 µg 293T whole cell lysate/extract B. 30 µg A431 whole cell lysate/extract C. 30 µg HeLa whole cell lysate/extract D. 30 µg HepG2 whole cell lysate/extract E. 30 µg A375 whole cell lysate/extract 7.5 % SDS-PAGE CD2AP antibody , dilution: 1:1000 100 μL 3 to 4 Days
$466.18
Détails
Humain Lapin Inconjugué ELISA, FACS, ICC, IHC (fro), WB Western blot analysis of CD2AP using anti-CD2AP antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human Hela whole cell lysates, Lane 2: human 293T whole cell lysates, Lane 3: human MCF-7 whole cell lysates, Lane 4: human COLO-320 whole cell lysates, Lane 5: human 22RV1 whole cell lysates, Lane 6: human SK-OV-3 whole cell lysates, Lane 7: rat stomach tissue lysates, Lane 8: rat liver tissue lysates, Lane 9: mouse liver tissue lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CD2AP antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CD2AP at approximately 85KD. The expected band size for CD2AP is at 71KD. Flow Cytometry analysis of A431 cells using anti-CD2AP antibody . Overlay histogram showing A431 cells stained with  (Blue line).The cells were blocked with 10% normal goat serum. And then incubated with rabbit anti-CD2AP Antibody (,1µg/1x106 cells) for 30 min at 20°C. DyLight®488 conjugated goat anti-rabbit IgG (BA1127, 5-10µg/1x106 cells) was used as secondary antibody for 30 minutes at 20°C. Isotype control antibody (Green line) was rabbit IgG (1µg/1x106) used under the same conditions. Unlabelled sample (Red line) was also used as a control. 100 μg 4 to 6 Days
$280.00
Détails
Humain Lapin Inconjugué IHC, ELISA 100 μL 11 to 14 Days
$419.83
Détails
Humain Lapin Inconjugué IF, IHC (p), WB Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with CD2AP polyclonal antibody  at 1:250-1:500 dilution. Immunofluorescent staining of human cell line U-251 MG with CD2AP polyclonal antibody  at 1-4 ug/mL dilution shows positivity in plasma membrane, cytoplasm. 100 μL 11 to 12 Days
$577.33
Détails
Humain Souris Inconjugué FACS, IHC (p), WB   100 μg 4 to 6 Days
$280.00
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat lung tissue labeled with Anti-CD2AP Polyclonal Antibody (ABIN669486), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat lung tissue labeled with Anti-CD2AP Polyclonal Antibody  , Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$317.90
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from mouse brain, using CD2AP antibody. Western blot analysis of CD2AP expression in Hela cell lysate,The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué ELISA, WB   100 μL 11 to 13 Days
$335.04
Détails
Humain Lapin Inconjugué ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin-embedded Liver tissue 100 μg 13 to 16 Days
$384.00
Détails
Rat Lapin Inconjugué ICC, IHC, WB Western Blot; Sample: Rat Testis lysate; Primary Ab: 1µg/ml Rabbit Anti-Rat CD2AP Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 13 to 16 Days
$418.00
Détails

Plus d’anticorps contre CD2-Associated Protein partenaires d’interaction

Zebrafish CD2-Associated Protein (Cd2ap) interaction partners

  1. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.

Human CD2-Associated Protein (Cd2ap) interaction partners

  1. Study identified a homozygous frameshift mutation in CD2AP (p.S198fs) in three siblings born of consanguineous parents who developed childhood-onset focal segmental glomerulosclerosis (FSGS) and end stage renal disease. When the same mutation was introduced in mice by gene editing, the mice developed FSGS and kidney failure. These results provide conclusive evidence that homozygous mutation of CD2AP causes FSGS in humans.

  2. PAWS1 interacts in a dynamic fashion with the actin/cytoskeletal regulator CD2AP at lamellae, suggesting that its association with CD2AP controls actin organization and cellular migration. Genetic ablation of CD2AP from U2OS cells instigates actin and cell migration defects reminiscent of those seen in PAWS1-knockout cells.

  3. CD2AP is indicated as a protein up-regulated by HCV infection, which, in turn, stimulates HCV propagation and steatosis by disrupting insulin signaling; targeting CD2AP may offer an opportunity for alleviating HCV infection and its associated liver pathology

  4. CD2AP is an sporadic-Alzheimer's-disease risk gene in a southern Chinese Han population.

  5. data suggest that CD2AP acts as a negative regulator of ICAM-1 clustering, which limits the formation of ICAM-1 adhesion complexes to prevent uncontrolled neutrophil adhesion and transcellular transmigration.

  6. CD2AP expression in renal tubules may histologically associate with tissue hypoxia and reflected recovery from CsA-mediated renal injury in nephrotic syndrome patients.

  7. data thus reveal a Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively.

  8. Silencing Cindr in nephrocytes led to dramatic nephrocyte functional impairment and shortened life span, as well as collapse of nephrocyte lacunar channels and effacement of nephrocyte slit diaphragms. These phenotypes could be rescued by expression of a wild-type human CD2AP gene, but not a mutant allele derived from a patient with CD2AP-associated NS.

  9. Study found a novel association of CD2AP with plasma homocysteine in participants with African ancestry and found a new variant in the candidate gene CBS associated with homocysteine

  10. CD2AP rs9349407 polymorphism contributes to Alzheimer's disease susceptibility.

  11. discovered novel interaction candidates for CD2AP and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL, ALIX, and RIN3

  12. we present the first demonstration that the purified SH3 domains of the CD2AP/Cin85 protein family are able to directly bind the p53 protein, and to discriminate between the two polymorphic variants P72R

  13. CD2-Associated Protein affects Abeta levels and Abeta42/Abeta40 ratio in vitro

  14. CD2AP gene variants may contribute to susceptibility to end-stage renal disease in patients with type 1 diabetes.

  15. FSGS3/CD2AP has a role of barbed-end capping in junctional actin dynamics.

  16. an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate ErbB2 protein levels in physiological and pathological settings

  17. E2F1 up-regulates the human CD2AP promoter.

  18. CD2AP is highly expressed in human plasmacytoid dendritic cells (DC) and positively regulates blood DC antigen 2 (BDCA2)/Fc fragment of IgE high affinity I receptor (FcepsilonR1gamma) signaling.

  19. identifies CD2AP as the gatekeeper of the podocyte TGF-beta response through its regulation of CatL expression and defines a molecular mechanism underlying proteinuric kidney disease

  20. The urinary mRNA profiles of synaptopodin, podocalyxin, CD2-AP, alpha-actin4, and podocin were found to increase with the progression of diabetic nephropathy.

Cow (Bovine) CD2-Associated Protein (Cd2ap) interaction partners

  1. The authors identified a CLASP1/CD2AP/EB1-containing protein complex that surrounds the Theileria annulata schizont throughout the host cell cycle. This complex also includes the schizont membrane protein Ta-p104 together with a novel secreted Theileria annulata protein (encoded by TA20980), which they term microtubule and SH3 domain-interacting protein (TaMISHIP).

Mouse (Murine) CD2-Associated Protein (Cd2ap) interaction partners

  1. Study identified a homozygous frameshift mutation in CD2AP (p.S198fs) in three siblings born of consanguineous parents who developed childhood-onset focal segmental glomerulosclerosis (FSGS) and end stage renal disease. When the same mutation was introduced in mice by gene editing, the mice developed FSGS and kidney failure. These results provide conclusive evidence that homozygous mutation of CD2AP causes FSGS in humans.

  2. The data suggest that inhibition of the catalytic activity of SHIP2 is beneficial in reducing oxidative stress, but leads to deleterious increase in apoptosis in podocytes with reduced expression of CD2AP.

  3. CD2AP is indicated as a protein up-regulated by HCV infection, which, in turn, stimulates HCV propagation and steatosis by disrupting insulin signaling; targeting CD2AP may offer an opportunity for alleviating HCV infection and its associated liver pathology

  4. We used the HIM technology to investigate at nanometer scale resolution the ultrastructural alterations of the glomerular filtration apparatus in mice lacking the critical slit diaphragm-associated protein CD2AP, highlighting the great potential of HIM to provide new insights into the biology and (patho)physiology of glomerular diseases.

  5. Ang II induces the relocalization and reduction of CD2AP via AT1R, which would cause podocyte apoptosis by the suppression of CD2AP/PI3-K signaling

  6. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.

  7. Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta in neurons increasing the risk for late-onset AD.

  8. CD2AP forms a complex with GGA2, a clathrin adaptor, which sorts Glut4 to GSVs, suggesting a role for CD2AP in this process.

  9. CD2AP is the first signaling molecule associated with adult sensory axonal collateral sprouting

  10. CD2AP has role in mediating blood-brain barrier integrity and cerebrovascular roles of CD2AP could contribute to its effects on Alzheimer's disease risk.

  11. CD2-Associated Protein affects Abeta levels and Abeta42/Abeta40 ratio in vitro

  12. only the SH3 domains of CD2AP are necessary to enhance the E3 ligase activity of Cbl-3/c toward Ret51

  13. CD2AP is not involved in the regulation of type I IFNs in plasmacytoid dendritic cells. Its major function is on the actin cytoskeleton, affecting migration to local lymph nodes under conditions of inflammation.

  14. CD2AP deficiency results in the excretion of intact albumin in knockout mice.

  15. the formation of lamellipodia is mediated by a complex of cortactin, CD2AP, and actin capping protein

  16. These data descrived the importance of concomitant decreases in podocin, CD2AP and tensin2 during septic acute renal failure-associated proteinuria.

  17. Sh3kbp1 is SUMOylated by SUMO-1, -2, and -3 and that SUMOylation is enhanced in the presence of Cd2ap.

  18. identifies CD2AP as the gatekeeper of the podocyte TGF-beta response through its regulation of CatL expression and defines a molecular mechanism underlying proteinuric kidney disease

  19. Coexpression of CIN85/Ruk(L) with CD2AP led to a decreased binding of CIN85/Ruk(L) to nephrin and podocin, which indicates a functional competition between CD2AP and CIN85/Ruk(L).

  20. CD2AP is expressed in glomerular podocytes, and may play a role in a specialized adhesion complex known as the slit diaphragm.

CD2-Associated Protein (Cd2ap) profil antigène

Profil protéine

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

Gene names and symbols associated with Cd2ap

  • CD2-associated protein L homeolog (cd2ap.L) anticorps
  • CD2 associated protein (CD2AP) anticorps
  • CD2-associated protein (cd2ap) anticorps
  • CD2 associated protein (cd2ap) anticorps
  • CD2-associated protein (Cd2ap) anticorps
  • CD2 associated protein (Cd2ap) anticorps
  • AL024079 anticorps
  • C78928 anticorps
  • cd2apl anticorps
  • CMS anticorps
  • DKFZp469E061 anticorps
  • fj51c01 anticorps
  • im:7153970 anticorps
  • METS-1 anticorps
  • Mets1 anticorps
  • si:ch211-207n9.1 anticorps
  • wu:fj51c01 anticorps
  • zgc:103705 anticorps

Protein level used designations for Cd2ap

CD2-associated protein , Cas ligand with multiple Src homology 3 (SH3) domains , adapter protein CMS , cas ligand with multiple SH3 domains , hypothetical protein , SH3 domain-containing adapter protein , SH3 domain-containing adaptor protein METS-1 , mesenchyme to epithelium transition protein, SH3 domains , mesenchyme-to-epithelium transition protein with SH3 domains 1

GENE ID SPECIES
445851 Xenopus laevis
472241 Pan troglodytes
494040 Danio rerio
705221 Macaca mulatta
100014892 Monodelphis domestica
100158527 Xenopus (Silurana) tropicalis
100172673 Pongo abelii
100341696 Oryctolagus cuniculus
100386627 Callithrix jacchus
100466982 Ailuropoda melanoleuca
100554210 Anolis carolinensis
100600076 Nomascus leucogenys
23607 Homo sapiens
771715 Gallus gallus
474928 Canis lupus familiaris
533188 Bos taurus
12488 Mus musculus
316258 Rattus norvegicus
100731393 Cavia porcellus
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