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CUL9 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. De plus, nous expédions Cullin 9 Kits (13) et et beaucoup plus de produits pour cette protéine.
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Human Polyclonal CUL9 Primary Antibody pour IF, WB - ABIN541213
Skaar, Arai, DeCaprio: Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development. dans Molecular and cellular biology 2005
Show all 2 Pubmed References
Results in U2OS cells demonstrate that the functions of CUL9 in regulating cell proliferation and maintaining genomic integrity are mainly mediated by p53, and that CUL9 is a critical p53 activator.
PARC (also known as CUL9) was found to be the ubiquitin ligase responsible for the ubiquitination and proteasomal degradation of cytochrome c, thus promoting cell survival.
PARC-mediated ubiquitination and degradation of Cyt c is a strategy engaged by both neurons and cancer cells to prevent apoptosis during conditions of mitochondrial stress.
the regulation of p53 subcellular localization and apoptosis by PARC as a contributing factor in CDDP resistance in OVCA cells and Ca(2+)/calpain in PARC post-translational processing and chemosensitivity.
Parc, a Parkin-like ubiquitin ligase,is a critical regulator in controlling p53 subcellular cytoplasmic localization and subsequent function.
FUBP1 is an authentic substrate of Parkin that might play an important role in development of Parkinson disease pathology along with aminoacyl-tRNA synthetase interacting multifunctional protein type 2
CPH domain interaction surface of p53 resides in the tetramerization domain and is formed by residues contributed by at least two subunits
PARC and CUL7 subcomplexes exhibit E3 ubiquitin ligase activity in vitro.
These studies suggest that PARC-interacting peptides are promising candidates for the enhancement of p53-dependent apoptosis in tumors with wt cytoplasmic p53.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
A 3M-CUL9-survivin pathway is implicated in maintaining microtubule and genome integrity, normal development, and tumor suppression.
Dimerization of Cul7 and Parc is not required for all Cul7 functions and mouse development.
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses.
, UbcH7-associated protein 1
, p53-associated parkin-like cytoplasmic protein
, parkin-like cytoplasmic p53 binding protein
, cullin 9
, LOW QUALITY PROTEIN: cullin-9