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CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. De plus, nous expédions CTLA4 Anticorps (455) et CTLA4 Protéines (82) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 51 products:
Data show that CTLA-4(+)PD-1 (Montrer PDCD1 Kits ELISA)(-) memory CD4 (Montrer CD4 Kits ELISA)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (Montrer GUSB Kits ELISA), and contained replication-competent and infectious virus.
The potential of the CTLA4 and G250 co-expression DNA vaccine.
Tregs were observed to regulate CD4 (Montrer CD4 Kits ELISA)(+), but not CD8 (Montrer CD8A Kits ELISA)(+), T cell infiltration into tumors through a CTLA-4/CD80 (Montrer CD80 Kits ELISA) dependent mechanism. Disrupting CTLA-4 interaction with CD80 (Montrer CD80 Kits ELISA) was sufficient to induce CD4 (Montrer CD4 Kits ELISA) T cell infiltration into tumors.
These results suggest that CD44 (Montrer CD44 Kits ELISA)(+)CD117(+) T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 pathway.
data suggest that increased expression of checkpoint blockade molecules PD-1 (Montrer PDCD1 Kits ELISA) and CTLA-4 on donor T cells is not sufficient to prevent GvHD, and that cooperation between checkpoint blockade signaling by host cells and donor Tregs is necessary to limit GvHD in allo-HSCT recipients
Treg cells expand in both humans and mice in blood-stage malaria and interfere with conventional T helper cell responses and follicular T helper (TFH)-B cell interactions in germinal centers. Mechanistically, Treg cells function in a critical temporal window to impede protective immunity through cytotoxic-T-lymphocyte-associated protein-4 (CTLA-4).
CTLA-4 expressed by FOXP3 (Montrer FOXP3 Kits ELISA)(+) regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.
results are consistent with a complex pathway in which CD28 (Montrer CD28 Kits ELISA) is the primary driver of Treg proliferation and CTLA-4 functions as the main brake but is also dependent on TCR signals and interactions with CD80 (Montrer CD80 Kits ELISA)/CD86 (Montrer CD86 Kits ELISA)
CTLA-4(+) microvesicles can competitively bind B7 costimulatory molecules on bystander dendritic cells, resulting in downregulation of B7 surface expression.
this study shows that miR (Montrer MLXIP Kits ELISA)-155 is modulated by a major dust mite allergen, Dermatophagoides farinae (Df1), and increases CD4 (Montrer CD4 Kits ELISA)+ T cell proliferation through the downregulation of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expression
CTLA-4 regulates atherosclerosis by suppressing proatherogenic immune responses.
The Genetic analysis of this study revealed that the very early onset JMG had a more prominent genetic predisposition in an immunomodulating gene (CTLA4).
Association between CTLA4 G allele/GG genotype and acute rejection risk in renal transplantation was found in this meta-analysis (G allele: OR=1.21, 95% CI: 1.03-1.44, P=.02; GG genotype: OR=1.37, 95% CI: 1.10-1.69, P=.004). However, the AA genotype was not associated with acute rejection risk in renal transplantation.
CTLA-4 polymorphisms are significant risk factors for transplant-related mortality and survival in children undergoing allogeneic hematopoietic stem cell transplantation and should be evaluated in further trials.
Review/Meta-analysis: CTLA4 +49A/G polymorphisms increased the risk of type 1 diabetes mellitus in children, and can be considered to be a genetic marker for T1D in children.
Information regarding CTLA-4 polymorphisms and haplotypes may be used to improve multiple myeloma therapy.
CTLA-4 gene polymorphism is associated with kidney allograft dysfunction.
the 'GG/G' of CTLA4 +49AG SNP, HLA-DRB1*11/-DRB1*12 (DR5) alleles and the combinations of DRB1*11/DRB1*12 alleles with AG/GG genotype and DRB1*04/07/12 alleles with GG genotype may act as synergistic manner to confer the strong susceptibility to autoimmune thyroid diseases in south India
regulatory effect of the mannose receptor (MR) was mediated by a direct interaction with CD45 (Montrer PTPRC Kits ELISA) on the T cell, inhibiting its phosphatase activity, which resulted in up-regulation of CTLA-4 and the induction of T-cell tolerance. Inhibition of CD45 (Montrer PTPRC Kits ELISA) prevented expression of B-cell lymphoma 6 (Bcl-6 (Montrer BCL6 Kits ELISA)), a transcriptional inhibitor that directly bound the CTLA-4 promoter and regulated its activity
The results of our study suggest no significant association between CD28 (Montrer CD28 Kits ELISA) rs1980422, CCL5 (Montrer CCL5 Kits ELISA) rs2107538, CTLA-4 exon 1 +49A>G rs231775 and rs3087243 gene polymorphisms and RA in the Polish population.
Results showed that high CTLA4 but low PD-1 (Montrer PDCD1 Kits ELISA) expression were associated with a poor overall survival of patients with breast cancer.
Suggest a truncated diphtheria toxin based recombinant porcine CTLA-4 fusion toxin as a novel approach for in vivo depletion of CD80 (Montrer CD80 Kits ELISA)-positive cells.
The surface expression of CTLA-4 was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 (Montrer ZAP70 Kits ELISA) were decreased in CD4 (Montrer CD4 Kits ELISA)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.
These results suggested that the expression level of CTLA-4 in CD4 (Montrer CD4 Kits ELISA)-positive T cells has a potentially immunosuppressive function in bovine leukemia infection.
Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 (Montrer FOXP3 Kits ELISA) and CTLA4.
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
cytotoxic T-lymphocyte-associated protein 4 precursor
, CD152 protein
, cytotoxic T-lymphocyte protein 4
, cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM
, cytotoxic T-lymphocyte-associated protein 4
, costimulatory molecule B7 receptor
, cytotoxic T lymphocyte-associated antigen 4
, CD152 antigen
, cytotoxic T-lymphocyte-associated antigen 4
, CD152 isoform
, celiac disease 3
, cytotoxic T lymphocyte associated antigen 4 short spliced form
, cytotoxic T-lymphocyte antigen 4
, cytotoxic T-lymphocyte-associated serine esterase-4
, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
, soluble form
, transmembrane form
, cytotoxic T lymphocyte-associated protein 4
, costimulatory molecule B7 receptor CD152