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The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. De plus, nous expédions et et beaucoup plus de produits pour cette protéine.
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Human Polyclonal XPO7 Primary Antibody pour ELISA, WB - ABIN547228
Kutay, Hartmann, Treichel, Calado, Carmo-Fonseca, Prehn, Kraft, Gorlich, Bischoff: Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. dans The Journal of biological chemistry 2001
Knockdown of exportins 4, 5, and 7 altered thyroid hormone receptor shuttling dynamics, and when exportins 5 and 7 were overexpressed, TR distribution shifted toward the cytosol.
Human oligodendrogliomas cells stably expressing mutant XPO7 showed altered cell proliferation.
RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 have roles in serous epithelial ovarian cancer
Knockdown of XPO7 reduced the amount of nuclear p65 following TNF stimulation. XPO7 binding to p65 is NLS independent
These biochemical and functional data reveal RANBP16 and RANBP17 as novel regulators of E2A protein action, and demonstrate specific interaction of E12 with RANBP17.
Exportin 7-dependent nuclear export signals differ fundamentally from the leucine-rich, CRM1-dependent ones
STRADalpha facilitates nuclear export of LKB1 by serving as an adaptor between LKB1 and exportins CRM1 and exportin7.
Knockdown of Xpo7 in primary fetal liver erythroblasts resulted in severe inhibition of chromatin condensation and enucleation but otherwise had little effect on erythroid differentiation, including hemoglobin accumulation.
This study demonstrateg that exportin-7 responds to ischemia in astrocytes.
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex\; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.
, exportin 7
, RAN binding protein 16
, ran-binding protein 16