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seven transmembrane domain G-protein coupled receptor\; most often found in sensory neurons [RGD, Feb 2006].. De plus, nous expédions G Protein-Coupled Receptor MRGX2 Kits (4) et et beaucoup plus de produits pour cette protéine.
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Human Monoclonal MRGPRX2 Primary Antibody pour CyTOF, FACS - ABIN4899057
Fujisawa, Kashiwakura, Kita, Kikukawa, Fujitani, Sasaki-Sakamoto, Kuroda, Nunomura, Hayama, Terui, Ra, Okayama: Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria. dans The Journal of allergy and clinical immunology 2014
Show all 2 Pubmed References
the present study demonstrates that FceRI (Montrer FCER1A Anticorps) and MRGPRX2 function can be inversely regulated by SCF (Montrer KITLG Anticorps) in an acute scenario, suggesting that the signaling requirements differ profoundly between the routes.
The authors discuss the possibility that MRGPRX2 responds to various as-yet-unidentified endogenous ligands that have specific characteristics, and propose that MRGPRX2 plays an important role in regulating inflammatory responses to endogenous harmful stimuli, such as protein breakdown products released from damaged or dying cells.
these peptides are identified as fragments of albumin (Montrer ALB Anticorps). The isolated fragments activate MRGPRX2 and degranulate MRGPRX2 expressing LAD (Montrer DLD Anticorps) 2 cells in dose-dependent manner. The isolated basic peptides generated from human albumin (Montrer ALB Anticorps) are able to degranulate mast cells via the MRGPRX2.
The results showed a kind of mechanism that sinomenine-induced anaphylactoid reactions were mediated by MRGPRX2 via activating PLC (Montrer HSPG2 Anticorps) molecular signaling pathways to provoke mast cells Ca(2 (Montrer CA2 Anticorps)+) mobilization and degranulation.
data suggest that mast cells play important roles in both gingival homeostasis and periodontal disease by orchestrating an interaction between gingival epithelial cells and neutrophils via MRGPRX2-mediated degranulation
MRGX2 is related to nociception, adrenal gland secretion and mast cell degranulation. (Review)
Ectopic expression of MrgX2 in rat basophilic leukemia RBL-2H3 cells and murine bone marrow mast cells renders these cells responsive to human beta-defensin (Montrer DEFB1 Anticorps) for degranulation.
identified MrgX2 as a novel G protein-coupled receptor for the antibacterial peptide LL-37 and demonstrated that unlike most G protein-coupled receptors it is resistant to agonist-induced receptor phosphorylation, desensitization, and internalization.
cortistatin-14 (Montrer CORT Anticorps) shown to be a high affinity ligand for G protein coupled receptor MrgX2 which is expressed in dorsal root ganglion
MRGX2 amino acid substitutions may alter the interactions between MRGX2 protein and its ligand, thus, potentially led to adaptive changes of the pain-perception-related nervous system during human evolution.
seven transmembrane domain G-protein coupled receptor\; most often found in sensory neurons
G protein-coupled receptor MRGX2
, mas-related G-protein coupled receptor member X2
, MAS-related GPR, member B10
, mas-related G-protein coupled receptor member B10
, MAS-related G protein-coupled receptor, member B1
, MAS-related gene B1