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The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. De plus, nous expédions HBG1 Protéines (14) et HBG1 Kits (10) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal HBG1 Primary Antibody pour ELISA, WB - ABIN561232
Lee, Kim, Byrnes, de Vasconcellos, Noh, Rabel, Meier, Miller: A synthetic model of human beta-thalassemia erythropoiesis using CD34+ cells from healthy adult donors. dans PLoS ONE 2013
A significant relationship between two variations (+25G/A and -499T/A) in Agamma gene promotor and fetal hemoglobin levels was observed.
study describes the characterization of the rs368698783 (+25 G->A) polymorphism of the Agamma-globin gene associated in beta(0)39 thalassemia patients with high HbF in erythroid precursor cells
Introduction of the British HPFH mutation into the fetal globin promoter in a human cell model causes elevated fetal globin expression. The British HPFH mutation creates a de novo binding site both in vitro and in vivo for the potent erythroid activator KLF1 (Montrer KLF1 Anticorps).
A Ly1 antibody reactive (LYAR)-binding motif disruptive regulatory single-nucleotide polymorphisms rs368698783 (G/A) from LD block 5 in the proximal promoter of hemoglobin subunit gamma 1 (HBG1) was found to be a significant predictor for beta-thalassemia clinical severity.
Study found a novel polymorphism of the A-gamma-globin gene in four families with b0-thalassemia and high levels of HbF expression. Additionally, evidence suggesting that the Ac-globin gene +25(G-A) polymorphism decreases the efficiency of the interaction between this sequence and specific DNA binding protein (Montrer UBE2V1 Anticorps) complexes.
These data confirm the regulatory role of the HBG1: g.-225_-222 region that exerts its effect under conditions of erythropoietic stress characteristic for beta-thal patients.
results suggest that KLF1 directly regulates the beta-globin gene, but probably has less direct impact on expression of the gamma-globin gene in fetal erythroblasts
Data show that the ancestral allele C at rs2855126, located upstream of gamma-globin (HBG1) is associated with increased serum uric acid levels.
analysis of a point mutation that increases fetal globin expression through de novo recruitment of the activator TAL1 to promote chromatin looping of distal enhancers to the modified gamma-globin promoter
a successful induction of gamma-globin includes a reduction in BCL11A (Montrer BCL11A Anticorps), KLF1 (Montrer KLF1 Anticorps) and TAL1 (Montrer TAL1 Anticorps) expression.
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
epsilon 3 globin
, hemoglobin Y beta-like embryonic chain
, hemoglobin Y, beta-like embryonic chain
, hemoglobin, epsilon 1
, hemoglobin, gamma A
, A-gamma globin
, gamma A hemoglobin
, gamma globin
, hb F Agamma
, hemoglobin gamma-1 chain
, hemoglobin gamma-a chain
, hemoglobin subunit gamma-1
, hemoglobin, gamma, regulator of
, hemoglobin, gamma G