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The protein encoded by IL1F10 is a member of the interleukin 1 cytokine family. De plus, nous expédions IL1F10 Protéines (19) et IL1F10 Kits (13) et beaucoup plus de produits pour cette protéine.
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Il-38-deficiency did not impact the development or resolution of Imiquimod-induced skin inflammation.
IL-38 overexpression attenuates the severity of experimental arthritis. IL-38 may exert its anti-inflammatory effects by decreasing the production of proinflammatory cytokines by macrophages and synovial fibroblasts.
The serum level of IL-38 in the children in the acute phase of Kawasaki disease was significantly lower than that in the healthy control group
IL-38 may play an important role in acute and/or chronic inflammation in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis.
IL-38 may exert its anti-inflammatory effects by decreasing the production of proinflammatory cytokines by macrophages and synovial fibroblasts.
this clinical study demonstrates the elevation of anti-inflammatory cytokine IL-38 and the decrement of CD4+CD25highFoxP3+ and CD4+CD25highCD127- Treg in childhood asthma. The negative correlation of IL-38 and Treg lymphocytes may imply a negative feedback of the two anti-inflammatory factors in asthma.
this study shows that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production
Higher serum IL-38 levels before treatment indicate a greater probability of viral response to telbivudine treatment in chronic hepatitis B.
results indicate that circulating IL-38 is a potentially novel biomarker for patients with ST-segment elevation myocardial infarction
Data suggest that IL-38 may be protective in SLE. A strong association between IL-38 and SLE severity suggests that IL-38 expression is driven by processes linked to SLE pathogenesis.
rs6759676, closest gene locus IL1F10 is associated with increased circulating levels of IL-1 receptor antagonist, a protective factor in development of insulin resistance.
The IL1A locus was strongly associated with alkylosing spondyloarthritis phenotype, whereas IL1F10 was associated with non-alkylosing spondyloarthritis.
These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.
, interleukin 1 family, member 7
, interleukin-1 family member 10
, FIL1 theta
, IL-1 theta
, IL-1F10 (canonical form IL-1F10a)
, interleukin-1 HY2
, interleukin-1 receptor antagonist FKSG75
, interleukin-1 receptor antagonist-like FIL1 theta