Microtubule Associated serine/threonine Kinase-Like (MASTL) Kits ELISA

MASTL encodes a microtubule-associated serine/threonine kinase. De plus, nous expédions MASTL Anticorps (92) et MASTL Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
MASTL 84930 Q96GX5
MASTL 67121 Q8C0P0
Anti-Rat MASTL MASTL 307169  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
Souris < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
  96 Tests Connectez-vous pour afficher 2 to 3 Days
Boeuf (Vache)
  96 Tests Connectez-vous pour afficher 15 to 18 Days
  96 Tests Connectez-vous pour afficher 15 to 18 Days
  96 Tests Connectez-vous pour afficher 15 to 18 Days

Plus Kits ELISA pour MASTL partenaires d'interaction

Zebrafish Microtubule Associated serine/threonine Kinase-Like (MASTL) interaction partners

  1. transient knockdown of MASTL correlates with a decrease in the expression of c-mpl and GpIIb, and reduction of circulating thrombocytes

Human Microtubule Associated serine/threonine Kinase-Like (MASTL) interaction partners

  1. E2F8 can shorten cisplatin induced G2/M arrest by promoting MASTL mediated mitotic progression in ER+ breast cancer cells, conferring drug resistance.

  2. Using mathematical modelling, this paper confirms that deactivation of MASTL is essential for mitotic exit.

  3. these results established that precise control of MASTL is essential to couple DNA damage to mitosis through the rate of mitotic entry and APC (Montrer APC Kits ELISA)/C activation.

  4. Thus, GWL is a human oncoprotein that promotes the hyperactivation of AKT via the degradation of its phosphatase, PHLPP, in human malignancies.

  5. Thus, Fcp1 (Montrer CTDP1 Kits ELISA) coordinates Cdk1 (Montrer CDK1 Kits ELISA) and Gwl inactivation to derepress PP2A (Montrer PPP2R4 Kits ELISA)-B55 (Montrer MINK1 Kits ELISA), generating a dephosphorylation switch that drives mitosis progression.

  6. Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA (Montrer AURKA Kits ELISA) network of neuroblastoma.

  7. Data show that siRNA knockdown of Forkhead box M1 (FOXM1 (Montrer FOXM1 Kits ELISA)) or microtubule-associated serine/threonine kinase-like (MASTL) induces radiosensitivity in non-small cell lung cancer (NSCLC).

  8. Mastl upregulation is involved in cancer progression and tumor recurrence after initial cancer therapy

  9. data demonstrate that GWL acts in a pathway with PP2A which is essential for prophase I exit and metaphase I microtubule assembly in mouse oocytes.

  10. Taken together our results suggest a hierarchy of phosphatases coordinating Greatwall, Ensa (Montrer ENSA Kits ELISA)/ARPP19 and Cdk (Montrer CDK4 Kits ELISA) substrate dephosphorylation during mitotic exit.

Mouse (Murine) Microtubule Associated serine/threonine Kinase-Like (MASTL) interaction partners

  1. using in vitro dephosphorylation assays, we demonstrate that Mastl promotes persistent MPS1 phosphorylation by inhibiting PP2A/B55 (Montrer MINK1 Kits ELISA)-mediated MPS1 dephosphorylation rather than affecting Cdk1 (Montrer CDK1 Kits ELISA) kinase activity. Our findings establish a key regulatory function of the Greatwall kinase/Mastl - PP2A/B55 (Montrer MINK1 Kits ELISA) pathway in preventing premature SAC (Montrer ADCY10 Kits ELISA) silencing

  2. Mastl is required for the timely activation of anaphase-promoting complex/cyclosome to allow meiosis I exit and for the rapid rise of Cdk1 (Montrer CDK1 Kits ELISA) activity.

  3. Data show that Mastl (Greatwall)-null cells display mitotic collapse after nuclear envelope breakdown (NEB (Montrer NEB Kits ELISA)) characterized by defective chromosome condensation and prometaphase arrest.

Xenopus laevis Microtubule Associated serine/threonine Kinase-Like (MASTL) interaction partners

  1. Data suggest Greatwall kinase (Gwl) associates with protein phosphatase 1 (PP1), particularly PP1gamma subunit, which mediates dephosphorylation of Gwl Ser (Montrer SIGLEC1 Kits ELISA)-883; consistent with mitotic activation of Gwl, its association with PP1 is disrupted in mitotic cells; subunits PPP1R3B and PPP1R13L (Montrer PPP1R13L Kits ELISA) associate with Gwl; thus, PPP1R3B appears to act as cell cycle regulator in oocytes that functions by governing Gwl dephosphorylation.

  2. Full dephosphorylation of Gwl results in complete inactivation of Arpp19 and ENSA (Montrer ENSA Kits ELISA), and dephosphorylation of mitotic substrates. this feed-back loop irreversibly induces mitotic exit.

  3. study provides evidence that PP1 targets the auto-phosphorylation site of Gwl, resulting in efficient Gwl inactivation; this step is necessary to facilitate subsequent complete dephosphorylation of Gwl by PP2A-B55 (Montrer MINK1 Kits ELISA)

  4. we showed that the Gwl nuclear localization is indispensable for the biochemical function of Gwl in promoting mitotic entry.

  5. PP2A-B55delta, Greatwall and ARPP19 are not only required for entry into meiotic divisions, but are also pivotal effectors within the Cdk1 (Montrer CDK1 Kits ELISA) auto-regulatory loop responsible for its independence with respect to the PKA-negative control.

  6. Greatwall kinase and cyclin B-Cdk1 (Montrer CDK1 Kits ELISA) are both critical constituents of M-phase-promoting factor.

  7. inhibition of PP2A-B55delta results from Ensa, that is phosphorylated in mitosis by the protein kinase Greatwall; this converts Ensa into specific inhibitor of PP2A-B55delta; this pathway represents a previously unknown element in mitosis control

  8. 3 phosphorylation sites (phosphosites) critical to Gwl activation (pT193, pT206, and pS883 in Xenopus laevis) located in evolutionarily conserved domains that differentiate Gwl from related kinases

  9. Coordinated interplays between Plx1 (Montrer PLK1 Kits ELISA) and Gwl are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.

  10. mitotic entry and maintenance is not only mediated by the activation of cyclin B-Cdc2 but also by the regulation of PP2A by GW

MASTL profil antigène

Antigen Summary

This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus.

Gene names and symbols associated with MASTL

  • microtubule associated serine/threonine kinase-like (mastl) anticorps
  • microtubule associated serine/threonine kinase like (MASTL) anticorps
  • serine/threonine-protein kinase greatwall (LOC100541707) anticorps
  • microtubule associated serine/threonine kinase-like (Mastl) anticorps
  • microtubule associated serine/threonine kinase like L homeolog (mastl.L) anticorps
  • 2700091H24Rik anticorps
  • C88295 anticorps
  • greatwall anticorps
  • GW anticorps
  • GWL anticorps
  • hGWL anticorps
  • im:7149025 anticorps
  • MAST-L anticorps
  • MASTL anticorps
  • RP11-85G18.2 anticorps
  • thc2 anticorps
  • wu:fa02a12 anticorps
  • zgc:100990 anticorps

Protein level used designations for MASTL

microtubule-associated serine/threonine-protein kinase-like , serine/threonine-protein kinase greatwall , microtubule associated serine/threonine kinase-like , greatwall protein kinase , Serine/threonine-protein kinase greatwall , Microtubule-associated serine/threonine-protein kinase-like

445215 Danio rerio
450367 Pan troglodytes
708134 Macaca mulatta
100441835 Pongo abelii
100514867 Sus scrofa
100541707 Meleagris gallopavo
100602092 Nomascus leucogenys
84930 Homo sapiens
67121 Mus musculus
307169 Rattus norvegicus
540206 Bos taurus
420487 Gallus gallus
607216 Canis lupus familiaris
100464443 Ailuropoda melanoleuca
414585 Xenopus laevis
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