Opioid Receptor, kappa 1 (OPRK1) Kits ELISA

a class of opioid receptors; show selective affinity for the endogenous opioid dynorphin. De plus, nous expédions Opioid Receptor, kappa 1 Anticorps (133) et Opioid Receptor, kappa 1 Protéines (3) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Humain OPRK1 OPRK1 4986 P41145
OPRK1 18387 P33534
OPRK1 29335 P34975
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Top Opioid Receptor, kappa 1 Kits ELISA sur anticorps-enligne.fr

Showing 2 out of 4 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Souris 0.28 ng/mL 0.78 ng/mL - 50 ng/mL 96 Tests 13 to 16 Days
Rat 0.469 ng/mL 0.78 ng/mL - 50 ng/mL A typical standard curve 96 Tests 13 to 16 Days

Plus Kits ELISA pour Opioid Receptor, kappa 1 partenaires d'interaction

Zebrafish Opioid Receptor, kappa 1 (OPRK1) interaction partners

  1. ZFOR3 is a unique model to study kappa opioid receptor functionality

Rabbit Opioid Receptor, kappa 1 (OPRK1) interaction partners

  1. These findings provide evidence that previously demonstrated KOR-mediated reduction in intraocular pressure could be caused, in part, by NO production in both the ciliary body and the trabecular meshwork.

Human Opioid Receptor, kappa 1 (OPRK1) interaction partners

  1. A history of child abuse specifically associated in the anterior insula with a downregulation of the kappa opioid receptor (Kappa), as well as decreased DNA methylation in the second intron of the Kappa gene.

  2. An OPRK1 variant is associated with delayed onset of levodopa-induced dyskinesias in patients with Parkinson's disease.

  3. Alcohol-dependent subjects have a significantly lower kappa opioid receptor availability compared to healthy controls across multiple brain regions.

  4. There was no association between OPRK1 SNPs and oral pain sensitivity.

  5. PDYN and OPRK1 showed transcriptionally coordinated pattern that was significantly different between alcoholics and controls.

  6. Absolute expression levels of PDYN were lower compared to those of OPRK1, suggesting that PDYN expression is a limiting factor in the DYN/KOR signaling, and that the PDYN downregulation diminishes efficacy of DYN/KOR signaling in dorsolateral prefrontal cortex of human alcoholics.

  7. There was no significant change in the expression of KOR as a function of the insertion-deletion in the promoter region (rs35566036), or as a function of depression status in anterior insula, anterior cingulate cortex, or mediodorsal thalamus. This variant strongly determines DNA methylation in KOR promoter, leading to a significant decrease in methylation levels of 8 nearby CpG dinucleotides.

  8. The OPRK1 gene variants showed significant association with susceptibility to opioid dependence among Iranians.

  9. Down-regulation of KOR in HCC tumour tissues has a strong association with poor prognosis and KOR might be a potential tumour suppressor.

  10. In HUVEC cells subjected to artificial hyperlipidemia, selective agonists and antagonists showed that kappa-opioid receptor stimulation normalizes endothelial ultrastructure and function under hyperlipidemic conditions via the PI3K/Akt/eNOS pathway.

  11. The OPRK1/kappa-opioid receptor pathway was found to be downregulated in lesional skin of psoriasis, correlating positively with itch sensation.

  12. Functional activity of Dynorphin 1-17 and fragments (1-6, 1-7 and 1-9) were screened over a range of concentrations against forskolin stimulated human embryonic kidney 293 (HEK) cells stably transfected with one of KOP, MOP or DOP

  13. These results indicate that KOR can form a heterodimer with B2R and this leads to increased protein kinase A activity by the CREB signaling pathway, leading to a significant increase in cell proliferation.

  14. that promoter fragments of OPRK1 and OPRM1 were able to upregulate gene expression with mild cognitive impairment

  15. Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel beta-arrestin-2-signaling pathway.

  16. Hypoxia inducible factor-1alpha (HIF-1alpha) siRNA knocked down the increase of endogenous HIF-1alpha messages and diminished the desferrioxamine (DFO)-induced increase of kappa-opioid receptor (hKOR) expression.

  17. genetic association studies in a population in Denmark: Data suggest that carriers/heterozygotes of the C allele (CC/CT) of OPRK SNP rs6473799 report a 30.4% higher mechanical visceral pain tolerance threshold than non-carriers.

  18. Molecular switches of the kappa opioid receptor triggered by 6'-GNTI and 5'-GNTI have been described.

  19. The study successfully developed a population PKPD model for oxycodone across three experimental pain types and investigated the association between 18 SNPs across all three opioid receptor genes (OPRM1, OPRK1, OPRD1) and analgesic response from oxycodone. None of the selected polymorphisms were significantly associated with analgesic response of oxycodone.

  20. data provide evidence for genetic modulation of opioid withdrawal severity.

Mouse (Murine) Opioid Receptor, kappa 1 (OPRK1) interaction partners

  1. Our results indicate that the stimulation of kappa-opioid receptors in the hippocampus may ameliorate cognitive dysfunction through the activation of the cholinergic system. These findings may offer a therapeutic alternative approach in the treatment of depression patients' symptoms

  2. Suggest that peripheral and central MOR and central KOR may be involved in the modulation of scratching behaviour in imiquimod-treated mice.

  3. chronic KOR activation increased phosphorylation of NR2B subunit of NMDA at tyrosine 1472 (pNR2B NMDA) in the hippocampus, but not in the cortex.

  4. Pre- and postsynaptic colocalization of kappa opioid receptor and D2R supports a role for kappa opioid receptor potentiating both the D2R inhibitory autoreceptor function and the inhibitory action of D2R on efferent medium spiny neurons. Kappa opioid receptor co-activation accelerates D2R sensitization by contributing to decrease dopamine release in the nucleus accumbens.

  5. Mechanical allodynia produced by monosodium iodoacetate (MIA) was enhanced in mice lacking KOR or PDYN gene. In contrast with the nociceptive manifestations induced by osteoarthritis, the increased microglial expression on the lumbar section of the spinal cord after MIA administration was similar in KOR-KO, PDYN-KO and WT littermates. Moreover, anhedonic- and anxiolytic-like states were revealed after MIA administration.

  6. The kappa opioid receptor was identified as a key player mediating the effects of buprenorphine in tests sensitive to antidepressant drugs in mice.

  7. This study provides the first evidence for a time- and learning-dependent property of neocortical kappa opioid receptor in facilitating acquisition and consolidation of associative memories.

  8. triazole 1.1 retained the antinociceptive and antipruritic efficacies of a conventional KOR agonist, yet it did not induce sedation or reductions in dopamine release in mice, nor did it produce dysphoria as determined by intracranial self-stimulation

  9. This study reports a cluster of compounds that are highly effective in enhancing remyelination and identifies kappa-opioid receptor (KOR) as a positive regulator for oligodendroglial differentiation, implicating KOR agonism as a potential strategy to accelerate remyelination.

  10. GRK2 upregulation causes kappa-opioid receptor desensitization in diabetic heart

  11. Study showed that Dyn-A, the endogenous kappa opioid receptor agonist, significantly hyperpolarized and inhibited neurons in the paraventricular nucleus of mouse thalamus

  12. Suggest that mixed cardiac ion channel blockade my mediated the antiarrhythmia actions of kappa-opioid receptor antagonist PD117,302.

  13. Anti-nociception mediated by a KOR agonist is blocked by a DOR agonist

  14. Findings suggest that activation of kappa opioid receptor (kappa-opioid receptor) reduces hyperglycemia in streptozotocin-induced diabetic mice.

  15. findings show that, during prolonged heroin abstinence, delta opioid receptors regulate hedonic homeostasis, while mu opioid receptor signaling in serotonergic pathways and kappa opioid receptors together control social behaviors

  16. kappa-Opioid receptor mediates the antinociceptive effect of nitrous oxide in mice.

  17. The data of this study provide evidence that KORs on VTA DA neurons are necessary to mediate KOR-mediated aversive behavior.

  18. Ablation of kappa-opioid receptors from brain dopamine neurons had anxiolytic-like effects.

  19. Natural food reward and systemic ghrelin activate Kappa opioid receptors in the ventral tegmental area.

  20. Data suggest that activation of neurokinin 3 and kappa-opioid receptors (NK3R and KOR) excites and inhibits kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons).

Opioid Receptor, kappa 1 (OPRK1) profil antigène

Antigen Summary

a class of opioid receptors\; show selective affinity for the endogenous opioid dynorphin

Gene names and symbols associated with OPRK1

  • opioid receptor, kappa 1 (oprk1) anticorps
  • opioid receptor kappa 1 (OPRK1) anticorps
  • opioid receptor, kappa 1 (Oprk1) anticorps
  • opioid receptor kappa 1 (Oprk1) anticorps
  • K-OR-1 anticorps
  • KOR anticorps
  • KOR-1 anticorps
  • LOC780448 anticorps
  • MSL-1 anticorps
  • OPRK anticorps
  • OPRK1 anticorps
  • Oprk2 anticorps
  • R21 anticorps

Protein level used designations for OPRK1

ZFOR3 , ZfKOR , kappa-type opioid receptor , opioid receptor, kappa 1 , kappa opioid receptor , K-OR-1 , KOR-1 , Opiate receptor, kappa-1 , opioid receptor, kappa 2

360139 Danio rerio
428533 Gallus gallus
486951 Canis lupus familiaris
780448 Ovis aries
100152118 Sus scrofa
100354170 Oryctolagus cuniculus
100587333 Nomascus leucogenys
4986 Homo sapiens
540519 Bos taurus
18387 Mus musculus
29335 Rattus norvegicus
100135587 Cavia porcellus
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