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The protein encoded by KCNN4 is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. De plus, nous expédions KCNN4 Protéines (3) et et beaucoup plus de produits pour cette protéine.
Showing 10 out of 85 products:
Human Polyclonal KCNN4 Primary Antibody pour WB - ABIN948055
Wong, Roberts, Randall: Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions? dans British journal of pharmacology 2014
Human Polyclonal KCNN4 Primary Antibody pour IF (p), IHC (p) - ABIN719786
Zhang, Yang, Yin, Yi, Shen, Zhao, Zhu, Liu: Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells. dans PLoS ONE 2016
Human Polyclonal KCNN4 Primary Antibody pour IHC, IHC (p) - ABIN4328499
Rabjerg, Oliván-Viguera, Hansen, Jensen, Sevelsted-Møller, Walter, Jensen, Marcussen, Köhler: High expression of KCa3.1 in patients with clear cell renal carcinoma predicts high metastatic risk and poor survival. dans PLoS ONE 2015
Blockade of K(Ca)3.1 by delivery of TRAM (Montrer TRAM1 Anticorps)-34 via balloon catheter prevented smooth muscle phenotypic modulation and limited subsequent restenosis in a swine model.
T-cell dependency on Kv1.3 (Montrer KCNA3 Anticorps) or KCa3.1 might be irreversibly modulated by antigen exposure.
present study was designed to evaluate in hereditary xerocytosis the functional link between mutated Piezo1 (Montrer PIEZO1 Anticorps) and KCNN4
this study reports cryo-electron microscopy (cryo-EM) structures of a human SK4-CaM channel complex in closed and activated states at 3.4- and 3.5-angstrom resolution, respectively.
Expression of intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1) mRNA and protein was detected in all three layers of the human cornea.
KCa3.1 channels are important modulators in hepatocellular homeostasis.
Tumor suppressor miR (Montrer MLXIP Anticorps)-497-5p down-regulates KCa3.1 expression and contributes to the inhibition of angiosarcoma malignancy development.
We identified a two-gene signature including KCNN4 and S100A14 (Montrer S100A14 Anticorps) which was related to recurrence in optimally debulked serous ovarian carcinoma patients
Human arrhythmogenic calmodulin mutations impede the activation of SK2 (Montrer KCNN2 Anticorps) channels in human embryonic kidney 293 cells.
This study found a very substantial functional expression of KCa3.1 channels in microglia from adult epilepsy patients.
Data show that RNAi-mediated knockdown of KCa3.1 and/or TRPC1 (Montrer TRPC1 Anticorps) leads to a significant decrease in cell proliferation due to cell cycle arrest in the G1 phase.
Blood brain barrier endothelial cells exhibit KCa3.1 protein and activity.
Diet-induced hyperhomocysteinemia enhanced myoendothelial feedback, and increased Cx37 (Montrer GJA4 Anticorps) and IK1 expression may contribute. nNOS (Montrer NOS1 Anticorps) or iNOS (Montrer NOS2 Anticorps) did not upregulate to compensate for decreased eNOS (Montrer NOS3 Anticorps), and they had little involvement in vasomotor function.
The Intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1-/- knockout mice) significantly reduced corneal fibrosis and expression of pro-fibrotic marker genes, suggesting that KCa3.1 plays an important role corneal wound healing in vivo.
KCa3.1(-/-) mice exhibited significantly smaller infarct areas in a model of ischemic stroke.
KCa3.1(-/-) mice demonstrated normal behavioral responses in models of acute nociceptive, persistent inflammatory, and persistent neuropathic pain. However, their behavioral responses to noxious chemical stimuli such as formalin and capsaicin were increased. Accordingly, formalin-induced nociceptive behavior was increased in wild-type mice after administration of the KCa3.1 inhibitor TRAM (Montrer TICAM2 Anticorps)-34.
SK4 activity is crucial for cell cycle control.
Following differentiation with LPS (Montrer TLR4 Anticorps) or a combination of LPS (Montrer TLR4 Anticorps) and IFN-gamma (Montrer IFNG Anticorps) microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa (Montrer CSN3 Anticorps) 3.1 and Kir (Montrer GEM Anticorps) currents, while microglia differentiated with IL-4 (Montrer IL4 Anticorps) exhibited large Kir (Montrer GEM Anticorps) 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa (Montrer CSN3 Anticorps) 3.1 currents were generally low
Deletion of KCa3.1 reduced astrogliosis and rescued memory loss induced by intrahippocampal Abeta1-42 peptide injection.
Dynamic coupling between TRPV4 (Montrer TRPV4 Anticorps) and Ca(2 (Montrer CA2 Anticorps)+)-activated SK1 (Montrer SPHK1 Anticorps)/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 (Montrer KCNMA1 Anticorps) in kidney collecting duct cells.
Blocking KCa3.1 suppresses plaque instability in advanced stages of atherosclerosis by inhibiting macrophage polarization toward an M1 phenotype.
enhanced KCa (Montrer CSN3 Anticorps) 3.1 activity may compensate for decreased nitric oxide signaling during vascular aging.
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
intermediate conductance calcium-activated potassium channel protein 4
, intermediate-conductance calcium-activated potassium channel
, intermediate conductance calcium-activated potassium channel protein 1
, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
, intermediate conductance calcium-activated potassium channel protein 4-like
, SKCa 4
, putative Gardos channel
, putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel
, intermediate conductance K channel
, intermediate-conductance Ca-activated K channel
, potassium intermediate-small conductance calcium-activated channel subfamily N member 4