anti-Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) Anticorps

The protein encoded by KCNN4 is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. De plus, nous expédions KCNN4 Protéines (3) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
KCNN4 3783 O15554
KCNN4 65206  
KCNN4 16534 O89109
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Top anti-KCNN4 Anticorps sur anticorps-enligne.fr

Showing 10 out of 85 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-KCNN4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate Host:  Rabbit  Target Name:  KCNN4  Sample Tissue:  Human Ovary Tumor  Antibody Dilution:  1.0ug/ml 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Boeuf (Vache) Chèvre Inconjugué IHC, IHC (p) Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué IF, IHC, WB 100 μL Connectez-vous pour afficher 16 Days
$334.77
Détails
Boeuf (Vache) Lapin Inconjugué IHC, IHC (p) Anti-KCNN4 antibody  ABIN1048992 IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-KCNN4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p) Anti-KCNN4 antibody  ABIN1048993 IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-KCNN4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, IHC, WB Western blot analysis of Jurkat cell extracts, using KCNN4 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276990 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, WB Western blot analysis of extracts from HepG2 cells, using KCNN4 antibody. ABIN6275200 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué WB Anti-KCNN antibody,  Western blotting All lanes: Anti KCNN() at 0.5ug/ml WB: HUT Whole Cell Lysate at 40ug Predicted bind size: 60KD Observed bind size: 60KD 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Humain Lapin Inconjugué WB KCNN4 (KCA3.1) Polyclonal Antibody 0.1 mg Connectez-vous pour afficher 6 to 8 Days
$379.50
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti KCNN4 Polyclonal Antibody, Unconjugated (ABIN719786) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: rat brain lysates Lane 2: rat heart lysates probed with Anti KCNN4 Polyclonal Antibody, Unconjugated (ABIN719786) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 50kD. Observed band size: 45kD, 50kD. 100 μL Connectez-vous pour afficher 3 to 7 Days
$318.45
Détails

anti-KCNN4 Anticorps mieux référencés

  1. Human Polyclonal KCNN4 Primary Antibody pour WB - ABIN948055 : Wong, Roberts, Randall: Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions? dans British journal of pharmacology 2014 (PubMed)

  2. Human Polyclonal KCNN4 Primary Antibody pour IF (p), IHC (p) - ABIN719786 : Zhang, Yang, Yin, Yi, Shen, Zhao, Zhu, Liu: Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells. dans PLoS ONE 2016 (PubMed)

  3. Human Polyclonal KCNN4 Primary Antibody pour IHC, IHC (p) - ABIN4328499 : Rabjerg, Oliván-Viguera, Hansen, Jensen, Sevelsted-Møller, Walter, Jensen, Marcussen, Köhler: High expression of KCa3.1 in patients with clear cell renal carcinoma predicts high metastatic risk and poor survival. dans PLoS ONE 2015 (PubMed)

Plus d’anticorps contre KCNN4 partenaires d’interaction

Pig (Porcine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blockade of K(Ca)3.1 by delivery of TRAM (Montrer TRAM1 Anticorps)-34 via balloon catheter prevented smooth muscle phenotypic modulation and limited subsequent restenosis in a swine model.

Human Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. T-cell dependency on Kv1.3 (Montrer KCNA3 Anticorps) or KCa3.1 might be irreversibly modulated by antigen exposure.

  2. present study was designed to evaluate in hereditary xerocytosis the functional link between mutated Piezo1 (Montrer PIEZO1 Anticorps) and KCNN4

  3. this study reports cryo-electron microscopy (cryo-EM) structures of a human SK4-CaM channel complex in closed and activated states at 3.4- and 3.5-angstrom resolution, respectively.

  4. Expression of intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1) mRNA and protein was detected in all three layers of the human cornea.

  5. KCa3.1 channels are important modulators in hepatocellular homeostasis.

  6. Tumor suppressor miR (Montrer MLXIP Anticorps)-497-5p down-regulates KCa3.1 expression and contributes to the inhibition of angiosarcoma malignancy development.

  7. We identified a two-gene signature including KCNN4 and S100A14 (Montrer S100A14 Anticorps) which was related to recurrence in optimally debulked serous ovarian carcinoma patients

  8. Human arrhythmogenic calmodulin mutations impede the activation of SK2 (Montrer KCNN2 Anticorps) channels in human embryonic kidney 293 cells.

  9. This study found a very substantial functional expression of KCa3.1 channels in microglia from adult epilepsy patients.

  10. Data show that RNAi-mediated knockdown of KCa3.1 and/or TRPC1 (Montrer TRPC1 Anticorps) leads to a significant decrease in cell proliferation due to cell cycle arrest in the G1 phase.

Cow (Bovine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blood brain barrier endothelial cells exhibit KCa3.1 protein and activity.

Mouse (Murine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Diet-induced hyperhomocysteinemia enhanced myoendothelial feedback, and increased Cx37 (Montrer GJA4 Anticorps) and IK1 expression may contribute. nNOS (Montrer NOS1 Anticorps) or iNOS (Montrer NOS2 Anticorps) did not upregulate to compensate for decreased eNOS (Montrer NOS3 Anticorps), and they had little involvement in vasomotor function.

  2. The Intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1-/- knockout mice) significantly reduced corneal fibrosis and expression of pro-fibrotic marker genes, suggesting that KCa3.1 plays an important role corneal wound healing in vivo.

  3. KCa3.1(-/-) mice exhibited significantly smaller infarct areas in a model of ischemic stroke.

  4. KCa3.1(-/-) mice demonstrated normal behavioral responses in models of acute nociceptive, persistent inflammatory, and persistent neuropathic pain. However, their behavioral responses to noxious chemical stimuli such as formalin and capsaicin were increased. Accordingly, formalin-induced nociceptive behavior was increased in wild-type mice after administration of the KCa3.1 inhibitor TRAM (Montrer TICAM2 Anticorps)-34.

  5. SK4 activity is crucial for cell cycle control.

  6. Following differentiation with LPS (Montrer TLR4 Anticorps) or a combination of LPS (Montrer TLR4 Anticorps) and IFN-gamma (Montrer IFNG Anticorps) microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa (Montrer CSN3 Anticorps) 3.1 and Kir (Montrer GEM Anticorps) currents, while microglia differentiated with IL-4 (Montrer IL4 Anticorps) exhibited large Kir (Montrer GEM Anticorps) 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa (Montrer CSN3 Anticorps) 3.1 currents were generally low

  7. Deletion of KCa3.1 reduced astrogliosis and rescued memory loss induced by intrahippocampal Abeta1-42 peptide injection.

  8. Dynamic coupling between TRPV4 (Montrer TRPV4 Anticorps) and Ca(2 (Montrer CA2 Anticorps)+)-activated SK1 (Montrer SPHK1 Anticorps)/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 (Montrer KCNMA1 Anticorps) in kidney collecting duct cells.

  9. Blocking KCa3.1 suppresses plaque instability in advanced stages of atherosclerosis by inhibiting macrophage polarization toward an M1 phenotype.

  10. enhanced KCa (Montrer CSN3 Anticorps) 3.1 activity may compensate for decreased nitric oxide signaling during vascular aging.

KCNN4 profil antigène

Profil protéine

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

Gene names and symbols associated with KCNN4

  • potassium calcium-activated channel subfamily N member 4 (KCNN4) anticorps
  • potassium calcium-activated channel subfamily N member 4 (Kcnn4) anticorps
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (Kcnn4) anticorps
  • hIKCa1 anticorps
  • hKCa4 anticorps
  • hSK4 anticorps
  • IK1 anticorps
  • IKCA1 anticorps
  • KCa3.1 anticorps
  • KCA4 anticorps
  • mIKCa1 anticorps
  • rKCNN4c anticorps
  • rSK4 anticorps
  • SK4 anticorps
  • SKCas anticorps

Protein level used designations for KCNN4

intermediate conductance calcium-activated potassium channel protein 4 , intermediate-conductance calcium-activated potassium channel , intermediate conductance calcium-activated potassium channel protein 1 , potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 , intermediate conductance calcium-activated potassium channel protein 4-like , SKCa 4 , SKCa4 , putative Gardos channel , putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel , IK1 , KCa4 , SK4 , intermediate conductance K channel , intermediate-conductance Ca-activated K channel , potassium intermediate-small conductance calcium-activated channel subfamily N member 4

GENE ID SPECIES
397081 Sus scrofa
456098 Pan troglodytes
100379254 Cavia porcellus
100391934 Callithrix jacchus
100468357 Ailuropoda melanoleuca
100593199 Nomascus leucogenys
3783 Homo sapiens
65206 Rattus norvegicus
534591 Bos taurus
484464 Canis lupus familiaris
16534 Mus musculus
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