anti-Runt-Related Transcription Factor 1 (RUNX1) Anticorps

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. De plus, nous expédions RUNX1 Kits (11) et RUNX1 Protéines (9) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top anti-RUNX1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 308 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB AML-1/Runx1 antibody tested by Western blot. Detection of AML-1/Runx1 by Western blot analysis. Positive detection of AML-1/Runx1 in nuclear extracts derived from Jurkat cells at 1:500 (lane 1) and 1:1,000 (lane 2) dilutions. 100 μL Connectez-vous pour afficher 1 to 2 Days
$507.50
Détails
Humain Lapin Inconjugué IHC (p), WB Anti-RUNX1/AML1 Picoband antibody ,  All lanes: Anti RUNX1  at 0.5ug/ml WB: Recombinant Human RUNX1 Protein 0.5ng Predicted bind size: 50KD Observed bind size: 50KD Anti-RUNX1/AML1 Picoband antibody ,  IHC(P): Mouse Intestine Tissue 100 μg Connectez-vous pour afficher 4 to 6 Days
$280.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB Sample Type : Mouse, post-natal day (p) 0 retinal ganglion cells Primary Antibody Dilution : 1:1500 Secondary Antibody : Donkey anti rabbit IgG Alexa 594 Secondary Antibody Dilution : 1:1000 Gene Name : RUNX1  Submitted by : Anonymous WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: PANC1 cell lysate There is BioGPS gene expression data showing that RUNX1 is expressed in PANC1 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-RUNX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Jurkat cell lysate RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells WB Suggested Anti-RUNX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: Jurkat cell lysate  RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-RUNX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Jurkat cell lysate RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells WB Suggested Anti-RUNX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500  Positive Control: Jurkat cell lysate  RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-RUNX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  SH-SYSY cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Boeuf (Vache) Lapin Inconjugué WB Host:  Rabbit  Target Name:  Runx1  Sample Type:  Mouse Skeletal Muscle lysates  Antibody Dilution:  1.0ug/ml 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-RUNX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  721_B cell lysate RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-RUNX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:7812500  Positive Control:  Human Small Intestine 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Poulet Lapin Inconjugué IC, IF, IHC, WB Immunofluorescent analysis of RUNX1 staining in THP1 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of RUNX1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails

anti-RUNX1 Anticorps mieux référencés

  1. Human Polyclonal RUNX1 Primary Antibody pour WB - ABIN2668716 : Zaidi, Dowdy, van Wijnen, Lian, Raza, Stein, Croce, Stein: Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. dans Cancer research 2009 (PubMed)
    Show all 19 Pubmed References

  2. Human Monoclonal RUNX1 Primary Antibody pour ELISA, WB - ABIN969390 : Marshall, Moore, Ohki, Kitabayashi, Patterson, Ornelles: RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. dans Journal of virology 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal RUNX1 Primary Antibody pour IF, IHC (p) - ABIN514054 : Hussein, Dralle, Theophile, Kreipe, Bock: Megakaryocytic expression of miRNA 10a, 17-5p, 20a and 126 in Philadelphia chromosome-negative myeloproliferative neoplasm. dans Annals of hematology 2009 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal RUNX1 Primary Antibody pour WB - ABIN537342 : Srivastava, Srivastava: Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. dans Leukemia research 2005 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal RUNX1 Primary Antibody pour ICC, ELISA - ABIN969389 : Zharlyganova, Harada, Harada, Shinkarev, Zhumadilov, Zhunusova, Tchaizhunusova, Apsalikov, Kemaikin, Zhumadilov, Kawano, Kimura, Hoshi: High frequency of AML1/RUNX1 point mutations in radiation-associated myelodysplastic syndrome around Semipalatinsk nuclear test site. dans Journal of radiation research 2008 (PubMed)

  6. Human Monoclonal RUNX1 Primary Antibody pour ELISA, WB - ABIN966980 : Ichikawa, Goyama, Asai, Kawazu, Nakagawa, Takeshita, Chiba, Ogawa, Kurokawa: AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis. dans Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 2 Pubmed References

  7. Cow (Bovine) Polyclonal RUNX1 Primary Antibody pour IHC, WB - ABIN2777187 : Takeshita, Ichikawa, Nitta, Goyama, Asai, Ogawa, Chiba, Kurokawa: AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. dans Leukemia 2008 (PubMed)

  8. Human Polyclonal RUNX1 Primary Antibody pour WB - ABIN2801939 : Miyoshi, Shimizu, Kozu, Maseki, Kaneko, Ohki: t(8,21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. dans Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 4 Pubmed References

  9. Human Polyclonal RUNX1 Primary Antibody pour IHC (p), WB - ABIN3043318 : Du, Li, Zhong, Fan, Qiao, He, Fu, Wang, Ye: Brain death induces the alteration of liver protein expression profiles in rabbits. dans International journal of molecular medicine 2014 (PubMed)

  10. Human Monoclonal RUNX1 Primary Antibody pour IF, IHC (p) - ABIN514053 : Keita, Bachvarova, Morin, Plante, Gregoire, Renaud, Sebastianelli, Trinh, Bachvarov: The RUNX1 transcription factor is expressed in serous epithelial ovarian carcinoma and contributes to cell proliferation, migration and invasion. dans Cell cycle (Georgetown, Tex.) 2013 (PubMed)

Plus d’anticorps contre RUNX1 partenaires d’interaction

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Runx/Cbfb complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation.

  2. Deletion of Runx1 in mouse T-ALL impairs cell growth. RUNX1 depletion consistently resulted in reduced cell proliferation and increased apoptosis.

  3. Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors

  4. RUNX1 promoted TGF-beta-induced partial EMT by increasing transcription of the PI3K subunit p110delta, which mediated Akt activation.

  5. The promoter regions of Runx1 is targets of STAT4 and that STAT4 binding during NK cell activation induces epigenetic modifications of Runx1 gene loci resulting in increased expression.

  6. Results suggest that AML1/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  7. Gene expression profiling of HEPs revealed a RUNX1c-induced proinflammatory molecular signature, supporting previous studies demonstrating proinflammatory signaling as a regulator of HSC emergence.

  8. In the Title.

  9. Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1, FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.

  10. the ability of Runx1 to induce endothelial-to-hematopoietic transition (EHT) in non-hemogenic endothelial cells depends on the anatomical location of the cell and the developmental age of the conceptus

  11. CDK6 kinase activity negatively regulates the conversion of fat-storing cells into fat-burning cells by suppressing RUNX1, and may be a therapeutic target for the treatment of obesity and related metabolic diseases

  12. RUNX1 dosage plays a pivotal role in hemogenic endothelium maturation and the establishment of the hematopoietic system.

  13. These results suggest that RUNX1 may be an essential modulator in BMP9- induced osteogenic differentiation of mesenchymal stem cells.

  14. Loss of Runx1 and Runx2 inhibits prostate cell motility.

  15. In vivo, in vitro and systems biology results show that Runx1 exerts a pro-neurogenic function in neural precursor cells in vitro, while in vivo data remained inconclusive.

  16. High RUNX1 expression is associated with lymphoma.

  17. Specific Runx1-bound enhancer elements critically modulate lineage-dependent expressions of PLZF.

  18. Study reveals a previously unrecognized synergism between ETV6/RUNX1 and BCL2 impacting on malignant disease and autoimmunity.

  19. Data provide evidence that Runx1 plays a role in regulating the sphingolipid rheostat in normal development and that perturbation of this cell fate regulator contributes to Runx-driven lymphomagenesis.

  20. The findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Study reports differential regulation of gene expression by RUNX1-RUNX1T1 oncoprotein and MAPK1 as determined by genome-wide expression analysis responsible for the phenotypic features of acute myeloid leukaemia with karyotypic discernible translocation (t)(8;21)(q22;q22).

  2. identified most of these factors as RUNX1-RUNX1T1 targets, with Ras Homolog Family Member (RHOB) overexpression being the core of this network

  3. Upregulated CASC2 may inhibit cell proliferation, migration, and invasion through regulating miR-18a-5p and its target gene RUNX1 in MM.

  4. The authors demonstrate that the transcriptional regulator Runx1 is essential for the generation of ROR-gammat expressing iNKT17 cells.

  5. As most transcriptional repressor proteins do not comprise tetramerization domains, our results provide a possible explanation as to the reason that RUNX1 is recurrently found translocated to ETO family members

  6. ransplant age (>45 years) and complex chromosome karyotype abnormality were negative prognostic factors in allogeneic hematopoietic stem-cell transplantation for myeloid neoplasms patients with RUNX1 mutations

  7. the effect of RUNX1 inhibition on the endothelial vascular niche cells

  8. Knockdown of RUNX1 in human T-cell acute lymphoblastic leukemia impairs cell growth and survival.RUNX1 depletion consistently resulted in reduced cell proliferation and increased apoptosis.RUNX1 has a net positive effect on cell growth in the context of established T-ALL.

  9. A microdeletion encompassing exons 1-2 of RUNX1 (outside the cluster region of the Runt Homology domain and the transactivation domain) was detected in six family members using array-CGH and MLPA validation

  10. The number of RUNX1mut, RUNX1 WT loss and the number and type of additional mutations is biologically and clinically relevant.

  11. In this study, the presence of clonal heterogeneity and impaired FCM-MRD clearance among ETV6/RUNX1-positive patients, ultimately influenced prognosis.

  12. Results show that Runx1 associates with c-Abl kinase through its C-terminal inhibitory domain which directly binds to c-Abl. Also, Runx1 is phosphorylated by c-Abl kinase modulating its transcriptional activity and megakaryocyte maturation.

  13. DEGs and pathways identified in the present study will help understand the molecular mechanisms underlying RUNX1 mutations in AML and develop effective therapeutic strategies for RUNX1-mutation AML.

  14. RUNX1 regulates ITGA6 through a consensus RUNX1 binding motif in its promoter

  15. Loss of RUNX1 resulted in enhanced proliferation, migration, and invasion of lung adenocarcinomas

  16. In the Title.

  17. Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors

  18. miR-144 mimics can inhibit the proliferation and migration of ovarian cancer cells though regulating the expression of RUNX1.

  19. The effect of FENDRR on cell proliferation, apoptosis and invasion and migration ability in protate cancer cells was suppressed by silence of RUNX1.

  20. KSRP, miR-129, and RUNX1 participate in a regulatory axis to control the outcome of myeloid differentiation.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. isolation and characterization by spatiotemporal expression detected in the developing zebrafish

  8. Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 profil antigène

Profil protéine

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • uncharacterized LOC473981 (LOC473981) anticorps
  • runt-related transcription factor (runt) anticorps
  • runt related transcription factor 1 (Runx1) anticorps
  • runt related transcription factor 1 (RUNX1) anticorps
  • runt-related transcription factor 1 (runx1) anticorps
  • runt related transcription factor 1 L homeolog (runx1.L) anticorps
  • runt-related transcription factor 1 (RUNX1) anticorps
  • runt-related transcription factor 1 (Runx1) anticorps
  • AI462102 anticorps
  • aml anticorps
  • aml-1 anticorps
  • Aml1 anticorps
  • aml1-evi-1 anticorps
  • amlcr1 anticorps
  • cbfa2 anticorps
  • evi-1 anticorps
  • Pebp2a2 anticorps
  • pebp2ab anticorps
  • Pebpa2b anticorps
  • Runx-1 anticorps
  • runx1 anticorps
  • runxa anticorps
  • XAML anticorps
  • Xaml1 anticorps

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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