SLAM Family Member 6 (SLAMF6) Kits ELISA

The protein encoded by SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. De plus, nous expédions SLAMF6 Anticorps (72) et SLAMF6 Protéines (25) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SLAMF6 114836 Q96DU3
SLAMF6 30925 Q9ET39
Anti-Rat SLAMF6 SLAMF6 498287  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 0.005 ng/mL n/a   96 Tests 11 to 16 Days
$673.75
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Souris
  96 Tests 21 to 31 Days
$796.95
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Plus Kits ELISA pour SLAMF6 partenaires d'interaction

Human SLAM Family Member 6 (SLAMF6) interaction partners

  1. Authors found that seSLAMF6 reduced activation-induced cell death and had an antiapoptotic effect on tumor-infiltrating lymphocytes.

  2. these results showed that the NTB-A/SAP pathway regulates T-cell activation and restimulation-induced cell death during human tuberculosis

  3. in addition to its established role in Invariant NKT(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans

  4. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  5. our data reveal how SAP nucleates a previously unknown signaling complex involving NTB-A and LCK to potentiate restimulation-induced cell death of activated human T cells.

  6. Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules.

  7. Data indicate that the dominance of the SLAMF3/SLAMF6 pathway in inducing IL-17A production can be attributed to an increased nuclear abundance and recruitment of RORgammat to the IL17A promoter.

  8. SLAMF3 and SLAMF6 T cell surface expression and IL-17 levels significantly correlate with disease activity in systemic lupus erythematosus patients

  9. Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 and IL-2 cytokine production

  10. Vpu downmodulation of NTB-A protects the infected cell from lysis by NK cells.

  11. regulation of interferon-gamma secretion, and not interleukin-4 in vitro, as well as inhibition of Th1 cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response

  12. NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells.

  13. blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity

  14. NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2

  15. The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A.

  16. HTLV-1-infected CD4+ T cells did not express ligands for NK cell activating receptors, NCR and NKG2D, although they did express ligands for NK cell coactivating receptors, NTB-A and 2B4.

  17. 2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review]

Mouse (Murine) SLAM Family Member 6 (SLAMF6) interaction partners

  1. Authors found that seSLAMF6 reduced activation-induced cell death and had an antiapoptotic effect on tumor-infiltrating lymphocytes.

  2. naive T cells regulate B cell survival in a SLAMF6-dependent manner

  3. in addition to its established role in Invariant NKT(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans

  4. CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects.

  5. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  6. study establishes a central role for germinal center B cell-specific CD84 and Ly108 expression in maintaining B cell tolerance in germinal centers and in preventing autoimmunity

  7. When Ly108 is engaged in trans during cell-cell interactions, Ly108-CD3zeta interactions are promoted in a manner that uniquely depends on Ly108 TM domain, leading to more efficient CD3zeta dephosphorylation.

  8. Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.

  9. Data indicate that Slamf6-H1 suppresses the spontaneous expansion of a unique osteopontin OPN+ T follicular helper (TFH) cells.

  10. Ly108 plays a role in the induction of PLZF in developing thymocytes.

  11. In the absence of SAP, signaling through the SLAM family members Ly108 and 2B4 resulted in increased recruitment of the SHP-1 phosphatase, associated with altered SHP-1 localization and decreased activation of Src kinases at the synapse.

  12. Ly 108 deletion in T4 cells reversed the Sh2d1a(-/-) phenotype, eliminating the SAP requirement for germinal centers and restoring NKT-cell differentiation. This required immunotyrosine switch motifs (ITSMs) & SHP-1 recruitment.

  13. 3 isoforms of Ly108 mRNA & protein are differentially expressed in the thymi of C57BL/6 & 129S6 mice expressing the lupus-resistant & lupus-prone haplotypes of Ly108, respectively. Ly108-H1 is a decoy isoform.

  14. an immune response-suppressing isoform of Ly108 can regulate the pathogenesis of lupus.

  15. Following targeted disruption of the LY108 gene, CD4+ T cell and innate responses are defective; a surprising role for Ly108 is revealed in the control of responses to bacteria by neutrophils, while macrophage functions are intact.

  16. normal Ly108.2 allele, but not lupus-associated Ly108.1 allele, sensitized immature B cells to deletion & RAG reexpression; as a potential regulator of tolerance checkpoints, Ly108 may censor self-reactive B cells, safeguarding against autoimmunity

  17. control of NKT cell numbers attributed to the Nkt1 gene is mediated by differential expression of Slamf1 and an additional contribution by Slamf6.

  18. 2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review]

  19. Ly108-triggered protein tyrosine phosphorylation was due to the capacity of SAP to recruit FynT

SLAMF6 profil antigène

Antigen Summary

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with SLAMF6

  • SLAM family member 6 (SLAMF6) anticorps
  • SLAM family member 6 (Slamf6) anticorps
  • CD352 anticorps
  • KAL1 anticorps
  • KAL1b anticorps
  • KALI anticorps
  • KALIb anticorps
  • Ly108 anticorps
  • NTB-A anticorps
  • NTBA anticorps
  • RGD1561848 anticorps
  • SF2000 anticorps
  • SLAMF6 anticorps

Protein level used designations for SLAMF6

SLAM family member 6 , activating NK receptor , NK-T-B-antigen , NTBA receptor , natural killer-, T- and B-cell antigen , lymphocyte antigen 108

GENE ID SPECIES
508183 Bos taurus
719728 Macaca mulatta
746886 Pan troglodytes
100156912 Sus scrofa
114836 Homo sapiens
30925 Mus musculus
498287 Rattus norvegicus
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