Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (C. Elegans) (SMG7) Kits ELISA

SMG7 encodes a protein that is essential for nonsense-mediated mRNA decay (NMD)\; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. De plus, nous expédions SMG7 Anticorps (32) et SMG7 Protéines (4) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Souris SMG7 SMG7 226517 Q5RJH6
SMG7 9887 Q92540
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain
  96 Tests 2 to 3 Days
$380.00
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Plus Kits ELISA pour SMG7 partenaires d'interaction

Human Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (C. Elegans) (SMG7) interaction partners

  1. Frameshift Mutations of SMG7 Essential for Nonsense-Mediated mRNA Decay in Gastric and Colorectal Cancers.

  2. Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long 3' UTRs involves both SMG6- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture.

  3. Transcriptome-wide identification of nonsense-mediated mRNA decay-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.

  4. We showed SMG7 mRNA levels in peripheral blood mononuclear cells correlated inversely with antinuclear antibody titres of patients with systemic lupus erythematosus. The inverse relationship between levels of the risk allele-associated SMG7 mRNAs and antinuclear antibody suggested the novel contribution of mRNA surveillance pathway to systemic lupus erythematosus pathogenesis.

  5. Depletion of nonsense-mediated mRNA decay pathway components Upf1, Smg5, and Smg7 led to increased levels of viral proteins and and virus release.

  6. The study demonstrates that SMG5-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex nonsense-mediated mRNA decay interaction network.

  7. Data show that phosphorylated hUPF1, the human ortholog of UPF1/SMG-2, forms a complex with human orthologs of the Caenorhabditis elegans proteins SMG-5 and SMG-7.

SMG7 profil antigène

Antigen Summary

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD)\; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with SMG7

  • Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) (Smg7) anticorps
  • SMG7, nonsense mediated mRNA decay factor (SMG7) anticorps
  • 9430023P16Rik anticorps
  • C1orf16 anticorps
  • EST1C anticorps
  • mKIAA0250 anticorps
  • SGA56M anticorps

Protein level used designations for SMG7

EST1-like protein C , protein SMG7 , EST1 telomerase component homolog C , breast cancer-associated antigen SGA-56M , ever shorter telomeres 1C , smg-7 homolog, nonsense mediated mRNA decay factor

GENE ID SPECIES
226517 Mus musculus
9887 Homo sapiens
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