Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) Kits ELISA

The protein encoded by UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. De plus, nous expédions UBA1 Anticorps (118) et UBA1 Protéines (7) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
UBA1 7317 P22314
UBA1 22201 Q02053
UBA1 314432 Q5U300
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Top UBA1 Kits ELISA sur anticorps-enligne.fr

Showing 8 out of 10 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 11.75 pg/mL 47-3000 pg/mL Typical standard curve 96 Tests 13 to 16 Days
$1,026.67
Détails
Souris 1.56 pg/mL 6.25-400 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Détails
Rat 0.1 ng/mL 1.0-25 ng/mL   96 Tests 15 to 18 Days
$707.14
Détails
Singe 1.0 U/L 5.0-100 U/L   96 Tests 15 to 18 Days
$707.14
Détails
Porc 0.1 ng/mL 5-100 ng/mL   96 Tests 15 to 18 Days
$707.14
Détails
Mouton
  96 Tests 15 to 18 Days
$707.14
Détails
Chévre
  96 Tests 15 to 18 Days
$707.14
Détails
Boeuf (Vache)
  96 Tests 15 to 18 Days
$707.14
Détails

Plus Kits ELISA pour UBA1 partenaires d'interaction

Human Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) interaction partners

  1. hUBA1 shares a conserved overall structure and mechanism with previously characterized yeast orthologs, but displays subtle structural differences, particularly within the active site.

  2. Polyubiquitination and proteasomal degradation of ezrin and CUGBP1 require Uba6, but not Uba1, and that Uba6 is involved in the control of ezrin localization and epithelial morphogenesis. These data suggest that distinctive substrate pools exist for Uba1 and Uba6 that reflect non-redundant biological roles for Uba6.

  3. Results from a study on gene expression variability markers in early-stage human embryos shows that UBA1 is a putative expression variability marker for the 3-day, 8-cell embryo stage.

  4. recent findings put UBA1 at the center of cellular homeostasis and neurodegeneration [review]

  5. A ubiquitin shuttle DC-UbP reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes.

  6. Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation

  7. Ubiquitin-activating enzyme is necessary for 17beta-estradiol-induced breast cancer cell proliferation and migration.

  8. We expressed and purified the N-terminal domains of human E1 and determined their crystal structures, which contain inactive adenylation domain (IAD) and the first catalytic cysteine half-domain (FCCH)

  9. Diminished ubiquitylation phenotype observed in enteropathogenic Escherichia coli infected cells corresponds to a strong reduction in the abundance of both Ube1 and Uba6.

  10. Decrease in free ubiquitin levels under stress allows NEDD8 to be conjugated through Ube1.

  11. UBA1 knockdown impairs formation of ubiquitin conjugates at DNA double-strand breaks.

  12. Data show that largazole and ester/keto analogs inhibit ubiquitin E1 activation.

  13. Ubiquitin and UBE1 are upregulated in tic epilepsy.

  14. In conclusion, nUBE1L is a novel human E1 like gene highly expressed in adult testis, which plays key role in ubiquitin system, and accordingly influences spermatogenesis and male fertility.

  15. analysis of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme

  16. unusual type of regulation at the level of the E1 enzyme is likely to affect numerous cellular processes and may represent a strategy to coordinate multiple phenotypic changes upon differentiation by using E1 as a "master switch."

  17. Human Uba6 and Ube1 have distinct preferences for E2 charging in vitro, and their specificity depends in part on their C-terminal ubiquitin-fold domains, which recruit E2s

  18. Large-scale mutation analysis in genes resulted in detection of 3 rare novel variants in exon 15 of UBE1 that segregate with X-linked infantile spinal muscular atrophy.

  19. high-level expression of UBE1 was seen inextranodal NK/T cell lymphoma, nasal type; there was no significant difference between UBE1 expression and patients' outcome

Mouse (Murine) Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) interaction partners

  1. Inhibition of ubiquitin-activating enzyme E1 (Ube1) increases the levels of high- molecular weight mouse Htt in relatively unaffected tissues, declining in the nuclear fraction with age.

  2. Dysregulation of UBA1 and subsequent ubiquitination pathways led to beta-catenin accumulation in a model of spinal muscular atrophy.

  3. These data suggest that Cys-278 can affect Ub charging through a change in the structural conformation of UBA1, not through direct interaction at the UBA1-Ub interface.

  4. biochemical and crystallographic characterization of the two half-domains and the crystal structure of the larger, second catalytic cysteine half-domain of mouse ubiquitin-activating enzyme

  5. E1 ligase of the proteasome is inhibitd by ziram and has a role in preventing dopaminergic cell damage

UBA1 profil antigène

Antigen Summary

The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.

Gene names and symbols associated with UBA1

  • ubiquitin like modifier activating enzyme 1 (UBA1) anticorps
  • ubiquitin activating enzyme E1 (uae1) anticorps
  • Ubiquitin-conjugating enzyme E1 (GL50803_4083) anticorps
  • Ubiquitin-conjugating enzyme E1 (GL50803_10661) anticorps
  • ubiquitin-like modifier activating enzyme 1 (Uba1) anticorps
  • ubiquitin-like modifier activating enzyme 1 S homeolog (uba1.S) anticorps
  • ubiquitin-like modifier activating enzyme 1 L homeolog (uba1.L) anticorps
  • ubiquitin-like modifier activating enzyme 1 (uba1) anticorps
  • ubiquitin activating enzyme E1 (ptr3) anticorps
  • ubiquitin like modifier activating enzyme 1 (Uba1) anticorps
  • a1s9 anticorps
  • a1s9t anticorps
  • a1st anticorps
  • amcx1 anticorps
  • DDBDRAFT_0190927 anticorps
  • DDBDRAFT_0220497 anticorps
  • DDB_0190927 anticorps
  • DDB_0220497 anticorps
  • gxp1 anticorps
  • poc20 anticorps
  • Sbx anticorps
  • smax2 anticorps
  • uba1 anticorps
  • uba1a anticorps
  • uba1b anticorps
  • ube anticorps
  • Ube-1 anticorps
  • ube1 anticorps
  • ube1x anticorps
  • wu:fa01e08 anticorps
  • wu:fb30f01 anticorps
  • wu:fi21c11 anticorps
  • wu:fj14g11 anticorps
  • zgc:66143 anticorps

Protein level used designations for UBA1

A1S9T and BN75 temperature sensitivity complementing , POC20 centriolar protein homolog , UBA1, ubiquitin-activating enzyme E1 homolog A , ubiquitin-like modifier-activating enzyme 1 , Ubiquitin-conjugating enzyme E1 , ubiquitin-activating enzyme E1, Chr X , ubiquitin-activating enzyme E1 , ubiquitin activating enzyme , fb30f01 , ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing) , Poly(A)+ RNA transport protein 3

GENE ID SPECIES
7317 Homo sapiens
8617637 Dictyostelium discoideum AX4
5700601 Giardia lamblia ATCC 50803
5700939 Giardia lamblia ATCC 50803
22201 Mus musculus
282869 Bos taurus
314432 Rattus norvegicus
379877 Xenopus laevis
398370 Xenopus laevis
406335 Danio rerio
100009225 Oryctolagus cuniculus
480896 Canis lupus familiaris
2540744 Schizosaccharomyces pombe 972h-
100726349 Cavia porcellus
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