PTPRJ anticorps (N-Term)

N° du produit ABIN1105887

Détail du produit anti-PTPRJ anticorps

Antigène: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Épitope: AA 1-444, N-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PTPRJ est non-conjugé

Application: Flow Cytometry (FACS)

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein-A affinity chromatography

Pureté: > 95 % pure by SDS-PAGE

Immunogène: Human recombinant CD148 (amino acids 1-444)

Clone: MEM-CD148-05

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), approx. pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PTPRJ

Antigène: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Autre désignation: CD148 / PTPRJ (PTPRJ Produits)

Synonymes: anticorps HAAP, anticorps CD148, anticorps DEP1, anticorps HPTPeta, anticorps R-PTP-ETA, anticorps SCC1, anticorps AI450271, anticorps BET, anticorps Byp, anticorps DEP-1, anticorps PTPbeta2, anticorps Ptpb2, anticorps RPTPJ, anticorps Scc-1, anticorps Scc1, anticorps PTPRJ, anticorps acid phosphatase 1, anticorps protein tyrosine phosphatase, receptor type J, anticorps protein tyrosine phosphatase, receptor type, J, anticorps ACP1, anticorps PTPRJ, anticorps Ptprj, anticorps EUBREC_2762

Sujet: CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.Synonyms: DEP-1, DEP1, HPTP eta, Protein-tyrosine phosphatase eta, Protein-tyrosine phosphatase receptor type J, R-PTP-J, R-PTP-eta, Receptor-type tyrosine-protein phosphatase eta

ID gène: 5795

NCBI Accession: NP_002834

UniProt: Q12913

Pathways: EGFR Signaling Pathway, Platelet-derived growth Factor Receptor Signaling