SOCS4 anticorps (C-Term)

N° du produit ABIN1109094

Détail du produit anti-SOCS4 anticorps

Antigène: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Épitope: C-Term

Reactivité: Humain, Boeuf (Vache), Porc

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS4 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Séquence: C-SKVRVLRIDA PEQQ

Specificité: This antibody detects SOCS-4 at C-term.

Réactivité croisée (Details): Species reactivity (expected):Pig, Bovine.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide with sequence from the C Terminus of Human SOCS4 (NP_543143.1, NP_955453.1). Genename: SOCS4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SOCS4

Antigène: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Autre désignation: SOCS4 (SOCS4 Produits)

Synonymes: anticorps SOCS7, anticorps socs4, anticorps SOCS4, anticorps 3110032M18Rik, anticorps A730004F22Rik, anticorps AI427843, anticorps AU015727, anticorps AU015859, anticorps Socs7, anticorps SOCS6, anticorps socs7, anticorps socs4a, anticorps suppressor of cytokine signaling 4, anticorps SOCS4, anticorps socs4, anticorps Socs4

Sujet: Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling) (1-3). Currently, there are eight members of the SOCS family that have been recognized, SOCS-1, -2, -3, -4, - 5, -6, -7 and CIS. Structurally, the SOCS proteins are composed of an N-terminus region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminus motif that has been called the SOCS box (4). The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STATinduced transcriptional mechanism (5). Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. Within the SOCS subfamily, SOCS-4, SOCS-5, SOCS-6, SOCS-7 remain poorly understood (6). On the basis of structural considerations, it would be expected that SOCS-4, -5, -6, and -7, like SOCS-1, SOCS-2, SOCS-3 and CIS, act to negatively regulate signal transduction (4), but it is uncertain which specific cytokine is involved (7-9).Synonyms: SOCS-4, SOCS-7, SOCS7, Suppressor of cytokine signaling 4, Suppressor of cytokine signaling 7

ID gène: 122809

NCBI Accession: NP_543143

UniProt: Q8WXH5

Pathways: Signalistation JAK/STAT, EGFR Signaling Pathway